171 episodios

Interviews with Neuroscientists about their New Books
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    • Ciencia

Interviews with Neuroscientists about their New Books
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    Christian Hansel, "Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains" (World Scientific, 2021)

    Christian Hansel, "Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains" (World Scientific, 2021)

    If you're interested in memory, you'll find a lot in Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains (World Scientific, 2021), from cellular processes to unique and interesting perspectives on autism.

    Detailed descriptions of cellular processes involved in forming a memory.

    Connecting those cellular processes to everyday experiences - like the memorable image of a butterfly seen during a hike decades ago.

    Comparisons of plasticity in different brain areas, like cortex, hippocampus, cerebellum.

    Comparisons of plasticity and learning in different phases of the human life.

    Important milestones in the history of neuroscience. Like Wiesel and Hubel's work identifying the critical period for plasticity, or Huttenlocher's discovery of synaptic pruning.

    Up-to-date science and open questions about autism, a wide range of phenomena that seems to be connected both to synaptic pruning and to the funtion of the cerebellum.

    An outlook on non-synaptic plasticity.


    Professor Christian Hansel starts both the book and the conversation with establishing a very broad definition of memory. Traditionally, a lot of research focused on the "observable outcome" of learning: acquiring new skills, changing behavior. Instead, he defines memory as any event that changes the brain.
    The first 2 chapters introduce major discoveries from the 1960s and 1970s. David Hubel and Thorsten Wiesel examined the visual system of kittens. They recognized that it's much more adaptive in a "critical period", ca. 4-8 weeks after birth. Peter Huttenlocher discovered another fascinating phenomena during childhood: synaptic pruning. In the years 2-12, a lot of synapses (connections between neurons) disappear.
    Chapter 3 describes the molecular machinery behind all these observations. We'll get to know the terms LTP (long-term potentiation) and LTD (long-term depression), which mean the long-term strengthening and weakening of synaptic connections respectively. We find a detailed description of these processes, incl. the enzymes, neurotransmitters and receptors contributing to them.
    Chapter 4 continues examining these processes across the human life span. The (perhaps surprising) conclusion: The machinery for synaptic plasticity is quite similar in a small child an in an adult. What's different is the magnitude of these processes.
    Autism is a central topic both in the book and in the Hansel Lab's work. Chapter 5 starts with describing the difficulties of a definition. ASD (autism spectrum disorder) is an umbrella term encompassing several symptoms and intensities. In the last years, it has turned out that low degree of synaptic pruning plays a significant role in multiple forms of autism. We'll see in the next years how the research about synaptic pruning and learning can be used for clinical purposes. Understanding the biological mechanism can also make it easier to relate to some peculiar-sounding symptoms. If we consider that an individual's brain contains an unusually high number of synapses, their reports about unusually intense perceptions suddenly become more understandable.
    A thought-provoking chapter is number 6. It describes various experiments with mouse models to study autism-like symptoms. The chapter might also make you reflect about the merits and shortcomings of animal models generally.
    The cerebellum was long considered to be the brain area for finetuning movements. Now, it's clear that its repertoire is much bigger. In the interview, Christian describes a hypothesis that the cerebellum has a capability of timing. This in turn makes it a crucial factor in several behaviors beyond sophisticated movements, including speech.
    We know a lot about synaptic plasticity and its significance in learning. Chapter 8 tackles the big, open question, what else? Which other processes contribute to memory formation? It presents some hypotheses about intrinsic plasticity.
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    • 1h 10 min
    Charan Ranganath, "Why We Remember: Unlocking Memory's Power to Hold on to What Matters" (Doubleday, 2024)

    Charan Ranganath, "Why We Remember: Unlocking Memory's Power to Hold on to What Matters" (Doubleday, 2024)

    A new understanding of memory is emerging from the latest scientific research. In Why We Remember: Unlocking Memory's Power to Hold on to What Matters (Doubleday, 2024), pioneering neuroscientist and psychologist Charan Ranganath radically reframes the way we think about the everyday act of remembering. Combining accessible language with cutting-edge research, he reveals the surprising ways our brains record the past and how we use that information to understand who we are in the present, and to imagine and plan for the future.
    Memory, Dr. Ranganath shows, is a highly transformative force that shapes how we experience the world in often invisible and sometimes destructive ways. Knowing this can help us with daily remembering tasks, like finding our keys, and with the challenge of memory loss as we age. What's more, when we work with the brain's ability to learn and reinterpret past events, we can heal trauma, shed our biases, learn faster, and grow in self-awareness.
    Including fascinating studies and examples from pop culture, and drawing on Ranganath's life as a scientist, father, and child of immigrants, Why We Remember is a captivating read that unveils the hidden role memory plays throughout our lives. When we understand its power-- and its quirks--we can cut through the clutter and remember the things we want to remember. We can make freer choices and plan a happier future.
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    • 1h 2 min
    Matt Qvortrup, "The Political Brain: The Emergence of Neuropolitics" (CEU Press, 2024)

    Matt Qvortrup, "The Political Brain: The Emergence of Neuropolitics" (CEU Press, 2024)

    In this episode of the CEU Press Podcast, host Andrea Talabér (CEU Press/CEU Review of Books) sat down with Matt Qvortrup (Coventry University) to discuss his new book with CEU Press entitled, The Political Brain: The Emergence of Neuropolitics (CEU Press, 2024).
    Putting the “science” back into political science, The Political Brain shows how fMRI-scans can identify differences between liberals and conservatives, can predict our behaviour, and can explain the biology of uprisings, revolutions, and wars. The book also provides an overview of the state-of-the-art knowledge of the organ that shapes our politics. It warns that if we rely on the evolutionarily primitive parts of the midbrain, those engaged when we succumb to polarised politics, we stand in danger of squandering the gains we made through the last eight million years.
    Matt’s book is part of our new series, CEU Press Perspectives. The series offers the latest viewpoints on both new and perennial issues, these books address a wide range of topics of critical importance today. The new series, originating from an international collection of leading authors, encourages us to look at issues from a different viewpoint, to think outside the box, and to stimulate debate.
    You can learn more about the series here.
    The CEU Press Podcast delves into various aspects of the publishing process: from crafting a book proposal, finding a publisher, responding to peer review feedback on the manuscript, to the subsequent distribution, promotion and marketing of academic books. We will also talk to series editors and authors, who will share their experiences of getting published and talk about their series or books.
    Interested in CEU Press’s publications? Click here to find out more: https://ceupress.com/
      Stay tuned for future episodes and subscribe to our podcast to be the first to be notified.
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    • 33 min
    Lawson R. Wulsin, "Toxic Stress: How Stress Is Making Us Ill and What We Can Do About It" (Cambridge UP, 2024)

    Lawson R. Wulsin, "Toxic Stress: How Stress Is Making Us Ill and What We Can Do About It" (Cambridge UP, 2024)

    Our stress response system is magnificent - it operates beneath our awareness, like an orchestra of organs playing a hidden symphony. When we are healthy, the orchestra plays effortlessly, but what happens when our bodies face chronic stress, and the music slips out of tune? 
    The alarming rise of stress-related conditions, such as heart disease, diabetes, and depression, show the price we're paying for our high-pressure living, while global warming, pandemics and technology have brought new kinds of stress into all our lives. But what can we do about it? 
    Explore the fascinating mysteries of our hidden stress response system with Dr. Wulsin, who uses his decades of experience to show how toxic stress impacts our bodies. In Toxic Stress: How Stress Is Making Us Ill and What We Can Do About It (Cambridge UP, 2024), Wulsin gives us the expert advice and tools needed to prevent toxic stress from taking over. Chapter by chapter, learn to help your body and mind recover from toxic stress.
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    • 28 min
    Max Bennett, "A Brief History of Intelligence: Evolution, Ai, and the Five Breakthroughs That Made Our Brains" (Mariner Books, 2023)

    Max Bennett, "A Brief History of Intelligence: Evolution, Ai, and the Five Breakthroughs That Made Our Brains" (Mariner Books, 2023)

    A Brief History of Intelligence: Evolution, Ai, and the Five Breakthroughs That Made Our Brains (Mariner Books, 2023) tells two fascinating stories. One is the evolution of nervous systems. It started 600 million years ago, when the first brains evolved in tiny worms. The other one is humans' quest to create more and more intelligent systems. This story begins in 1951 with the first reinforcement learning algorithm trying to mimic neural networks.
    Max Bennett is an AI entrepreneur and neuroscience researcher. His work combines insights from evolutionary neuroscience, comparative psychology, and AI. As each chapter describes how a skill evolved, it also explains whether(!) and how an AI system has managed to implement something similar. A recurring theme is how human brains and neural circuits have influenced AI architecture. The other side of this bi-directional connection is also intriguing. AI has often served as a litmus test, giving a clue how a not well understood neurobiological phenomenon might work, how plausible a hypothesis is.
    The organzining principle of this book is a framework of five breakthroughs, which compares evolution to technological innovation. Like a new technology enables several innovative products, a new brain capability enables several new skills. For example, mammals show several new intelligent behaviors compared to their ancestors: vicarious trial and error, episodic memory, and planning. The foundation of all these novelties, is probably the same capability: simulation.
    The five breakthroughs are:

     steering in bilaterians

    learning from trial and error in vertebrates

    simulating in mammals

    mentalizing in primates

    speaking in humans


    This framework guides the readers through a time travel of 600 million years. We learn about the environment in which these capabilities evolved: Who were the first mammals and why did planning benefit them? We see what contemporary animals can and can't do: Fish aren't as dumb as folklore suggests. And we take a look at AI's baffling achievements and limitations: Why can AI write decent essays but not load a dishwasher?
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    • 1h 9 min
    Kenneth Miller, "Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep" (Hachette Books, 2023)

    Kenneth Miller, "Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep" (Hachette Books, 2023)

    Why do we sleep? How can we improve our sleep?
    A century ago, sleep was considered a state of nothingness—even a primitive habit that we could learn to overcome. Then, an immigrant scientist and his assistant spent a month in the depths of a Kentucky cave, making nationwide headlines and thrusting sleep science to the forefront of our consciousness.
    In the 1920s, Nathaniel Kleitman founded the world’s first dedicated sleep lab at the University of Chicago, where he subjected research participants (including himself) to a dizzying array of tests and tortures. But the tipping point came in 1938, when his cave experiment awakened the general public to the unknown—and vital—world of sleep. Kleitman went on to mentor the talented but troubled Eugene Aserinsky, whose discovery of REM sleep revealed the astonishing activity of the dreaming brain, and William Dement, a jazz-bass playing revolutionary who became known as the father of sleep medicine. Dement, in turn, mentored the brilliant maverick Mary Carskadon, who uncovered an epidemic of sleep deprivation among teenagers, and launched a global movement to fight it.
    In Mapping the Darkness: The Visionary Scientists Who Unlocked the Mysteries of Sleep (Hachette Books, 2023), award-winning Kenneth Miller weaves together science and history to tell the story of four outsider scientists who took sleep science from fringe discipline to mainstream obsession through spectacular experiments, technological innovation, and single-minded commitment.
    Mapping the Darkness was named the Best Book of the Year 2023 by the New Yorker.
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    • 39 min

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