Biohacking Eve - Health Optimisation for Women

Judith Mueller
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Biohacking Eve - differentiated health optimisation for women. Let's make it all about Eve!Have you ever listened to the titans of Health Optimisation, Biohacking and Longevity and wondered “That’s all really great, but what if I’m a woman?”If so, welcome to “Biohacking Eve – Health Optimisation for Women!”My name is Judith Mueller and I’m here to help you navigate the maze of information by shining a light on true differentiation for women when it comes to health optimisation.Together, we will explore everything from how to fast intermittently without ruining your hormones all the way to abolishing menopause, and I will show you the latest in technology and research that can help you address your individual struggles and challenges in becoming your best self as a woman, as unique and individual as only you can be.Live long and prosper, my friend.

  1. 4 Aug

    #22 Pt2: How Microplastics End Up in Vaginal Tissue

    Send us Fan Mail In Part 2, materials engineer Shagun Maheshwari unpacks what conventional menstrual pads are actually made of — up to 90% plastic — and what that means for the body and the environment. Phthalates, microplastics, greenwashing, and why she designed Papaya to degrade in a landfill, not just a composter. Key topics in this part: - Why conventional pads can be up to 90% plastic; heat-bonding and textile engineering - Adhesives as a still-unsolved sustainability problem - Phthalates and VOCs; endocrine disruption and absorbent vulvovaginal tissue - Why fragrance can worsen period odour rather than mask it - Antimicrobial properties and the delicate vaginal microbiome balance - Microplastics vs nanoplastics, and how they reach tissue - Why plastic doesn't biodegrade; what genuine biodegradability requires - Greenwashing: "biodegradable top sheet," bamboo/cotton pads that still contain SAP, the label test - Industrial composter vs landfill degradation standards - Lifetime product volume (≈5,000–15,000 products); ~800-year SAP degradation - Where to find Papaya; what's next for the product - The case for putting people who experience the problem on the technical design team Timestamps: 00:00 — Hookable intro 00:42 — Biohacking Eve intro 01:07 — Recap of Part 1 01:27 — Episode summary 02:27 — Conversation resumes: plastics in pads 08:00 — Endocrine disruptors, fragrance, microbiome 16:00 — Microplastics and how they reach tissue 22:00 — Why plastic doesn't biodegrade; greenwashing and the label test 28:00 — Composter vs landfill; lifetime volume 33:00 — Where to find Papaya 34:00 — Curveball questions 40:00 — Close → outro References mentioned in this part: - Super absorbent polymer / sodium polyacrylate (SAP); polyacrylate, polypropylene, polyurethane - Phthalates; volatile organic compounds (VOCs) - Industrial composting vs landfill degradation standards (≈90% in six months) - Strange Pictures by Uketsu — Japanese mystery novel - Agatha Christie; P.G. Wodehouse (Jeeves and Wooster); Joseph Campbell (the hero's journey) Guest & product links: Website: papayapads.com Instagram: @papaya.india and @shagun.maheshwari LinkedIn (Shagun): https://www.linkedin.com/in/maheshwarishagun/ LinkedIn (company): https://www.linkedin.com/company/papayaindia/ Pilots in other countries: bulk orders only — contact Shagun directly Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  2. 21 July

    #22 Pt1: The Four Layers Inside a Supermarket Pad

    Send us Fan Mail Materials engineer Shagun Maheshwari spent five years building the world's first blood-coagulating menstrual pad. In Part 1, she explains why the industry tests pads against saline rather than blood, takes a conventional pad apart layer by layer, and reveals the reframe — keep dry, don't just absorb — that led to a pad which clots blood in place. Key topics in this part: Why pads are tested against water/saline, and how menstrual blood differsThe four-layer anatomy of a conventional pad (top sheet, ADL, core, back sheet)Super absorbent polymer (SAP) and why it collapses under body weightThe reframe from "absorb more" to "keep the person dry"How a physical, charge-based clot works (vs the biological clotting cascade)The naturally derived long-chain sugar coagulant, and how it was foundWhether some "period problems" are actually product-design problemsIndustry inertia around cheap, mass-produced SAP Timestamps: 00:00 — Hookable intro00:40 — Biohacking Eve intro01:05 — Episode summary02:05 — Conversation begins: from smart contact lenses to period pads07:00 — Optimising for the wrong metric; periods vs product problems14:00 — What's in blood, and why it's hard to engineer for16:00 — Pad anatomy, layer by layer20:00 — Why fluid comes back out under load21:00 — How coagulation works inside Papaya's pad28:00 — The coagulant material and how it was identified31:00 — Cliffhanger → outro References mentioned in this part: Mojo Vision — smart contact lens companySuper absorbent polymer / sodium polyacrylate (SAP)Stayfree, Whisper/Always — pad brands referenced Guest & product links: Website: papayapads.comInstagram: @papaya.india and @shagun.maheshwariLinkedIn (Shagun): https://www.linkedin.com/in/maheshwarishagun/LinkedIn (company): https://www.linkedin.com/company/papayaindia/Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  3. 23 June

    #20 Pt3: Could Endometriosis Be a Microbiome Disease?

    Send us Fan Mail In Part 3, Ronny Szelinsky moves into the frontier: AI-based endometrial diagnostics, the seeding event that shapes your baby's immune system at birth, the emerging theory that endometriosis may be a microbiome disease, and a clinical prediction for where gynaecological medicine is heading over the next decade. The episode closes with the curveball section, including book recommendations and perspectives on the gender health gap. Key Topics Seeding: how the birth canal colonises the newborn with foundational bacteria, and what C-section babies miss How to manually replicate seeding — and why most hospitals don't Why each successive birth reduces the mother's microbiome diversity AI diagnostics: inferring endometrial microbiome state from a vaginal swab (no biopsy) Applications for fertility clinics; pre-IVF screening; personalised probiotic protocols What is scientifically established vs currently speculative in the gynecological microbiome field Endometriosis as a potential endpoint of chronic microbiome dysfunction: the emerging theory Antimicrobial resistance and gynecological probiotics Why antibiotics sometimes trigger irregular bleeding — and the microbiome explanation Clinical prediction: microbiome assessment as routine gynaecological practice within ten years Curveball: recommended books, electrolytes, Rwanda project, ideal sidekick Timestamps [Part 3 start] — Seeding: the birth canal microbiome transfer [~05:00 into part] — C-section, missed seeding, manual replication [~08:00] — Why microbiome diversity declines with each birth [~10:00] — AI diagnostics: vaginal swab inference for endometrial state [~16:00] — Fertility clinic use cases; personalised probiotic prescribing [~20:00] — What is established vs speculative in the field [~23:00] — Endometriosis and the microbiome theory [~27:00] — Antibiotics, irregular bleeding, antimicrobial resistance [~30:00] — Ten-year clinical prediction [~33:00] — Curveball questions References and Resources Get Happy website: www.get-happy.com Ronny Szelinsky — LinkedIn: https://www.linkedin.com/in/ronny-szelinsky Darm mit Charme by Jill Enders (English: Gut — The Inside Story of Our Body’s Most Underrated Organ) Herzenssache by Prof. Michael Becker (not available in English) — book on the female heart and gender differences in cardiovascular medicine Boundless by Ben Greenfield — longevity and biohacking reference book; both Ronny and Judith recommend. Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  4. 9 June

    #20 Pt2: How the Pill Disrupts the Microbiome Long-Term

    Send us Fan Mail In Part 2, Ronny Szelinsky explains the mechanism behind oestrogen-driven microbiome collapse at menopause — and what can be done about it. He introduces the estrobolome, details the research behind Get Happy's Happy Fem probiotic formula, and explains why oral probiotics colonise the gynecological tract as effectively as vaginal delivery. This is the translational bridge between the science of Part 1 and the practical interventions of Part 3. Key Topics How oestrogen controls the thickness of the vaginal and endometrial tissue, and what happens when it dropsWhy UTIs become suddenly frequent after menopause — the biological mechanismVaginal dryness and pain during sex: the mucosal layer explainedThe estrobolome: the bacterial community around the ovaries and its proposed role in oestrogen productionThe contraceptive pill and its long-term impact on microbiome colonisation after stoppingHappy Fem: how the product was developed, the research methodology, and the fertility clinic partnershipsWhy oral probiotics achieve equivalent vaginal colonisation to vaginal administration — three pathwaysLactobacillus CA-15: what the published research showsWho should take vaginal probiotics and under what circumstancesWhen to pause: during pregnancy, and whyDosing: six-month courses for specific goals; ongoing daily use for post-menopausal women Timestamps [Part 2 start] — Hormone-microbiome axis, oestrogen and tissue thickness[~05:00 into part] — Why UTIs spike at menopause[~10:00] — The estrobolome: ovarian bacteria and oestrogen production[~17:00] — Happy Fem: product development and research methodology[~22:00] — Oral vs vaginal administration — clinical study results[~27:00] — Lactobacillus CA-15: what it does[~30:00] — Who should take it; when to pause; dosing logic References and Resources Happy Fem product: www.get-happy.comLactobacillus CA-15Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  5. 26 May

    #20 Pt1: What Wrecks Your Flora Down Under - Antibiotics, the Pill and Yes, Your Toys

    Send us Fan Mail In Part 1 of this conversation with Ronny Szelinsky, founder of Get Happy, we explore the gynecological microbiome — the bacterial community that spans the vagina, uterus, cervix, and urinary tract. Ronny explains why this microbiome operates by completely different rules to the gut, what happens when it becomes dysbiotic, and how its disruption can silently undermine fertility, hormonal health, and longevity. The science is newer than most people realise: the uterus was considered sterile until approximately 2018. Key Topics What the gynecological microbiome is and which anatomical areas it coversWhy Lactobacillus dominance — not diversity — is the marker of a healthy gynecological microbiomeThe discovery that the uterus is not sterile: what next-generation sequencing (NGS) revealedThe bidirectional microbiome-hormone axis: how bacteria and oestrogen regulate each otherWhat causes gynecological dysbiosis: the contraceptive pill, sexual intercourse, sex toys, antibiotics, thyroid medications, vaginal hygiene productsNormal menstrual inflammation vs chronic pathological inflammation — and the difference between themHow a dysbiotic microbiome attacks sperm and prevents embryo implantationWhy 50% of bacterial vaginosis cases have no symptoms — and what that means for unexplained infertility Timestamps 00:00 — Intro and episode overview01:00 — What the gynecological microbiome is; the body's multiple microbiomes03:00 — Reproductive ageing: what it means beyond fertility06:00 — Ronny's background and why he entered this field10:00 — Causes of gynecological dysbiosis: the pill, antibiotics, sexual activity, hygiene products15:00 — How the mucosal lining absorbs compounds and why topical exposure matters19:00 — The uterus is not sterile: the NGS sequencing revolution22:00 — Inflammation: normal vs pathological, and the menstrual cycle27:00 — Sperm attack and implantation failure: the fertility mechanism References and Resources Get Happy website: www.get-happy.comRonny Szelinsky — LinkedIn: https://www.linkedin.com/in/ronny-szelinskyNGS (Next-Generation Sequencing): technique referenced for identifying vaginal and uterine bacterial strainsBacterial vaginosis and Gardnerella vaginalis: standard medical references available on NHS/MedlinePlusInsta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  6. 12 May

    #19 Pt2: 48 Symptoms, Five Archetypes, Zero One-Size-Fits-All Solutions: Mapping the Future of Menopause

    Send us Fan Mail In Part 2, Anna Butterworth completes the five menopause archetypes with the Post-Menopausal Visionary and the Uninformed Endurer, then explores climate impacts on hormonal health, the VC funding problem in women’s health, and the curveball questions.   Key Topics: •  The Post-Menopausal Visionary: ageing as purpose, not decline •  The evolutionary argument: why humans and whales go through menopause •  Skin and vaginal dryness, muscle loss, osteoporosis in post-menopause •  Anti-ageing culture vs. embodying age •  Home health suites and at-home biomarker diagnostics •  The Uninformed Endurer: the forgotten consumer •  Low-barrier, affordable, stigma-free menopause solutions •  Why generic, scalable tools matter as much as personalised ones •  Upskilling primary care teams to identify menopause symptoms •  Environmental factors: PFAS, toxins, climate change and menstrual irregularity •  Why a one-degree temperature rise disproportionately affects women •  VC funding models and why they’re stunting women’s health innovation •  The Phase app and cycle-based productivity •  Book recommendations: Invisible Women and Unwell Women •  Anna’s unusual habit: a lifelong fascination with Mormon culture •  Investing in your team as the highest-return decision   References & Resources Mentioned: •  The Future of Menopause 2035 – Ultraviolet Agency report - https://www.ultravioletagency.com •  Phase app (phaseapp.io) – cycle-based productivity tool •  Biohacking Eve earlier episode with Maggie McDaris, founder of Phase -  https://podcasts.apple.com/au/podcast/15-aligning-work-with-biology-maggie-mcdaris-on-cycle/id1782080943?i=1000743385443 •  Invisible Women by Caroline Criado Perez •  Unwell Women by Elinor Cleghorn •  Iris Apfel – referenced as cultural example of ageing visionary •  Pamela Anderson – referenced as example of natural ageing in public life   Guest Links: •  Ultraviolet Agency – https://www.ultravioletagency.com •  Anna Butterworth LinkedIn – https://www.linkedin.com/in/annabutterworth Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  7. 28 Apr

    #19 Pt1: The Five Women You’ll Become in Menopause – And Why the System Isn’t Built for Any of Them

    Send us Fan Mail In Part 1, Anna Butterworth introduces the first three of five menopause archetypes from her Future of Menopause 2035 report – the Peri Prepper, the Seeker and the High Performer – exploring who each woman is, what she needs and where the current system falls short.   Key Topics: •  The Future of Menopause 2035 report and why archetypes matter •  48 symptoms of menopause and the problem with generic solutions •  The Peri Prepper: preparing for perimenopause in your mid-thirties •  GPs dismissing younger women who want to prepare early •  Millennials ageing into menopause with cycle-tracking literacy •  The AI slop era and the challenge of validating health information •  The Seeker: holistic wellness meets evidence-based rigour •  The gap between data-led tools and spiritually-oriented tools •  The High Performer: brain fog, boardrooms and the £150bn cost •  The link between menopause-related brain fog and long-term dementia risk •  Menopause benefits as the next frontier in talent retention •  The wisdom workforce: why younger women watch how companies treat older staff   References & Resources Mentioned: •  The Future of Menopause 2035 – Ultraviolet Agency report - https://www.ultravioletagency.com •  Bloomberg statistic: £150 billion global economic cost of menopause-related symptoms   Guest Links •  Ultraviolet Agency – https://www.ultravioletagency.com •  Anna Butterworth LinkedIn – https://www.linkedin.com/in/annabutterworth Insta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

  8. 14 Apr

    #18 Pt2: She Started HRT at 31 — Here's Why That Changed Everything

    Send us Fan Mail Episode description In Part 2, Yulia Mintchin gets practical — covering what women should actually do at every stage, the FemGene patient journey, her own health transformation on HRT at 31, and a surprising conversation about art, creativity and feminine power as the next frontier in women’s health Key topics discussed  Top three interventions for women aged 30–45  When to start genetic testing, with Yulia’s view being post-puberty  Cyclical nutrition: why carbs in the luteal phase support progesterone  Why cryotherapy and cold exposure can backfire depending on genetic stress response  Medical curriculum gaps: why perimenopause does not belong in sick care  The gold standard perimenopause visit in 2030  Will Be’s pharmacogenomic platform vision  Insurance models and the economics of preventative medicine  FemGene patient journey: telemedicine, test kits, Dr Vanessa consultation  Can oestrogen receptors reactivate post-menopause? Emerging research  Optimal hormones as a foundational baseline, not a longevity bonus  Peptides: only stack after hormonal foundations are in place  Yulia’s personal story: health crisis at 31, HRT and the endometriosis link  Keto, sourdough and changing her mind on carbs  The digital twin: which data streams matter and which are just noise  Curveball: the billboard question — rewriting behaviour patterns through art Remember Who You Are — Yulia’s musical  Joseph Campbell, the hero’s journey and stories as healing  Spiral dynamics and collective consciousness  A Russian utopian book by a female author written during the USSR period  Peptides for mitochondria as a sub-$1,000 purchase recommendation  Piano as an introvert’s creative practice  Biohacking Eve episode on EMS (Episode 3)  Timestamps 00:00 Why Part 2 is the action plan 01:00 Top interventions before HRT 02:20 Keto, carbs and cyclical eating 07:00 What a gold standard perimenopause visit should look like 09:30 Insurance, self-pay and democratising access 13:20 The research questions FemGene wants to answer 18:10 Why Yulia started HRT at 31 23:10 “It’s not too early” for hormone optimisation 25:00 Female digital twins and meaningful data 27:10 Why optimal hormones are a baseline, not a luxury 30:40 Why fasting and cryo are not for everyone 33:35 One change healthcare professionals can make now 35:50 Art, feminine energy and women’s health 44:30 The spiritual experiences behind Yulia’s mission 49:45 Peptides, piano and personal rituals 53:40 What comes next for Will Be and FemGene References and resources mentioned  FemGene hormone genomic test — via Will Be: https://www.mywillbe.co.uk/ Joseph Campbell — The Hero with a Thousand Faces Spiral dynamics — developmental model of collective consciousness  Biohacking Eve episode on EMS / strength training, referenced as approximately Episode 3  A Russian utopian book by a female author, written during the USSR period Remember Who You Are — musical by Yulia Mintchin  Health Optimisation Summit, London  Dr Vanessa — chief scientist at Will Be  Guest social links &nInsta/TikTok: @BiohackingEve Website: www.BiohackingEve.com

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Biohacking Eve - differentiated health optimisation for women. Let's make it all about Eve!Have you ever listened to the titans of Health Optimisation, Biohacking and Longevity and wondered “That’s all really great, but what if I’m a woman?”If so, welcome to “Biohacking Eve – Health Optimisation for Women!”My name is Judith Mueller and I’m here to help you navigate the maze of information by shining a light on true differentiation for women when it comes to health optimisation.Together, we will explore everything from how to fast intermittently without ruining your hormones all the way to abolishing menopause, and I will show you the latest in technology and research that can help you address your individual struggles and challenges in becoming your best self as a woman, as unique and individual as only you can be.Live long and prosper, my friend.

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