Roland Pankewich on Mitochondria and the Gut Health Connection The Gut Health Gurus Podcast

A mind-blowing conversation with mitochondrial health expert Roland Pankewich on the science of mitochondria, the connection between mitochondrial and gut health, how mitochondria communicate with gut microbiota, strategies to improve both gut and mitochondrial function and much more...
 

 

Bio: 
 
Roland Pankewich is the CEO of Health Optimization Practice Canada and the owner/operator of the country’s first Health Optimization Clinic. His focus within his clinical practice is to work with high performing individuals, including business owners and professional athletes to help them find optimal health and performance in their lives. His specialty is in the deep understanding of the gut-immune system and how to optimize its structure and function. This allows him to share his insights and research with clients and other professionals in order to help them better understand their own health.

 

Topics discussed:
How Roland met Mitochondrial health expert and mentor Ted Achacoso
What are mitochondria?
"Powerhouse of the cell definition" from 1957
Cellular currency - ATP
The importance of cellular energy
Mitochondrial sensing- “The cell danger response"
Cell lifespan
Calcium metabolism
Epigenetic control
Deuterium depleted matrix water
Uncoupling of mitochondrial proteins (UCPs) and thermal heat 
The Fourth Phase of water- Gerald Pollack
https://www.amazon.com.au/Fourth-Phase-Water-Beyond-Liquid-ebook/dp/B00N2ASKF2
Exclusion Zone (EZ) water- battery
Mitochondrial dysfunction and disease
Mitochondria and cell nucleus communication
Oxidation and Reduction agents (REDOX)
Pattern recognition receptors (PRR)
Damage associated molecular patterns (DAMPS)
Pattern associated molecular patterns (PAMPS)
Bacterial antigen binding to mitochondrial receptors
Cross mitochondria communication
Mitochondria - ancient archaea
Mitochondria - immune system alert and activation
What are reactive oxygen species (ROS) free radicals?
What is REDOX?
ROS signalling molecules
What is apoptosis?
What is necrosis?
The mitochondrial engines ATP synthase
Protein gradient and spin to produce ATP
Aerobic respiration vs fatty acids
Electron chain transport
Electron leakage and free radical production
Where is the highest concentration of mitochondria in the body?
The gut mitochondria connection
The Gut- last line of defence in the body
Mitochondria and gut microbiome interaction
PGC1 alpha, AMPK, SIRTUINS
What happens locally impacts the body systemically 
Why do we see disease manifested in the gut first?
Microbiome imbalance and inflammatory cascade
Gut- absorption system first and barrier second
Leaky gut, the tipping point
Immune system- Hurt or Heal
Tight junction proteins
Microbiota development for optimal host symbiosis 
Creating a harmonious environment for your microbiota and mitochondria
Gut Unicorns
How do mitochondria and microbiota communicate bidirectionally 
Microbiota metabolites for mitochondrial fuel
Short-chain fatty acids
Urolithins- Mitochondrial biogenesis 
Up-regulation of transcription factors PGC1 alpha, AMPK, SIRTUINS and fat metabolism
Mitochondria and gut barrier function
Redox status of the cell, gut barrier, microbiota and mitochondrial function
Metabolites Hydrogen sulphide, nitric oxide and mitochondrial energy production
Butyrate production - fuel for enterocytes
A new gut lining every 3 to 5 days
Drug targeting and microbiota
Molecular mimicry and autoimmune disease
How do we improve mitochondrial function?
Metabolic flexibility
Time-Restricted Eating
Cofactor for Mitochondrial Health
Micronutrient Dense Diet
Walking, High Intensity and Resistance Training
Optimising your Digestive System
Food Choices for optimal gut health
Variety of Plant foods for Microbiota diversity
What is Hormesi