The Critical Care Commute Podcast

Critical Care Commute

The Critical Care Commute Podcast is grateful for your ears, insights and feedback. In return its hosts- Peter Brindley and Leon Byker, two ICU doctors in Alberta, Canada- offer up knowledge and debate with some of the most qualified, interesting, enlightened and provocative folks in Critical Care Medicine, and beyond. We strive to keep it practical and concise. Like you, our overriding goal is to get better, do better and feel better.

  1. Precision Medicine - It may be easier than you think!

    29 OCT

    Precision Medicine - It may be easier than you think!

    In this episode, Peter and Leon, recording at the College of Intensive Care Medicine's Conference in Tasmania, Australia, discuss advancements in precision medicine with Dr. Pratik Sinha from Washington University in St. Louis. Dr Pratik trained in both Emergency and Intensive Care Medicine, but only works clinically as an intensivist. He runs a research program that seeks to change the way we identify and classify critically ill patients, by using a combination of novel biological measurements and state of the art data science approaches. The conversation delves into how critical care medicine currently operates, emphasizing the need to shift from supportive care to more personalized approaches using biological measuring systems, big data, and novel data science techniques. They discuss identifying patient subgroups using machine learning algorithms and protein biomarkers, revealing phenotypes like hyper and hypo-inflammatory responses. The discussion covers the practical challenges of implementing these technologies, the importance of rigorous testing, and the future implications for intensive care. The speakers highlight the necessity of prospective clinical trials and broader accessibility of these advanced diagnostic tools to improve patient outcomes. 00:00 Introduction and Opening Remarks 00:34 Diving into Precision Medicine 01:35 Elevator Pitch for Medical Research 02:10 Understanding Patient Complexity 04:12 Biological Measurements and Data Science 10:37 Challenges in Modern Medicine 17:08 Future of Medical Research and AI 21:20 Concluding Thoughts and Future Prospects

    31 min
  2. Sepsis Updated: Prof Mervyn Singer, Author of Sepsis 3.0

    3 SEPT

    Sepsis Updated: Prof Mervyn Singer, Author of Sepsis 3.0

    In this episode, we welcome Professor Mervyn Singer, author of Sepsis 3.0. Sepsis remains one of the most complex and deadly conditions in critical care. In this conversation,Professor Singer shares his perspectives on the shifting landscape of sepsis treatment, the role of antibiotics, steroids, metabolic interventions, and the future ofprecision medicine. He also challenges some long-standing dogmas and emphasizes the importance of individualized care over rigid guidelines. Key Topics and Chapters: The Evolution of Sepsis Management Historical perspectives on sepsis treatmentEarlier recognition and intervention leading to improved outcomesCurrent Challenges and Research Directions Organ dysfunction and recovery in sepsisThe importance of metabolic manipulation and mitochondrial functionThe Role of the Immune System in Sepsis Understanding hyper- and hypo-inflammatory responsesSteroid use in critical illness—when it works and when it doesn’tAntibiotics in Sepsis: How Soon, How Long, and How Much? The changing approach to antibiotic timing and durationThe impact of microbiome disruption and antibiotic toxicityRethinking the one-hour antibiotic ruleLessons from COVID-19 and Their Impact on Sepsis Research The importance of phenotype-driven treatmentsMissed opportunities in clinical trials and biobankingThe Beta-Blocker Debate in Sepsis Potential benefits in selected patientsThe challenge of distinguishing compensatory tachycardia from harmful sympathetic overdriveRethinking Fever Management Is fever protective or harmful?When to treat and when to leave it aloneGuidelines vs. Individualized Care The balance between evidence-based medicine and clinical expertiseThe dangers of rigid mandates and protocols This engaging discussion provides a fresh perspective on the current state and future of sepsis management, emphasizing the need for precision medicine, nuanced clinical decision-making, and ongoing research. References: Im Y, Kang D, Ko RE, et al. Time-to-antibiotics and clinical outcomes in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care. 2022;26(1):19. Published 2022 Jan 13. doi:10.1186/s13054-021-03883-0 HereSakkat A, Alquraini M, Aljazeeri J, Farooqi MAM, Alshamsi F, Alhazzani W. Temperature control in critically ill patients with fever: A meta-analysis of randomized controlled trials. J Crit Care. 2021;61:89-95. doi:10.1016/j.jcrc.2020.10.016 HereHasegawa D, Sato R, Prasitlumkum N, et al. Effect of Ultrashort-Acting β-Blockers on Mortality in Patients With Sepsis With Persistent Tachycardia Despite Initial Resuscitation: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Chest. 2021;159(6):2289-2300. doi:10.1016/j.chest.2021.01.009 Here

    27 min
  3. Long Term Outcomes after ICU, CPR, and Cardiogenic Shock

    6 AUG

    Long Term Outcomes after ICU, CPR, and Cardiogenic Shock

    Dr. Shannon Fernando is an intensivist at Lakeridge Health and a prolific researcher with over 150 publications. Known for his work in outcomes-based research across critical care, he joins us to discuss long-term outcomes after cardiogenic shock. About the Episode: This episode is part of our cardiovascular critical care series and explores what happens after the ICU for patients who survive cardiogenic shock. We unpack quality of life, functional outcomes, mental health, and the hidden burdens on both patients and caregivers. Dr. Fernando provides key data insights from his large cohort studies and shares reflections from ICU follow-up clinics. We also dive into the challenges of prognostication and how to communicate realistic expectations to families. Topics Covered Defining Long-Term Outcomes: Beyond survival: functional independence, mental health, cognition, and system resource use.Key Findings from Ontario Cohort 42% of cardiogenic shock survivors require increased levels of care15% die within a year post-dischargeModest impact of revascularization or mechanical support on long-term outcomesMorbidity and Quality of Life Loss of independence and inability to return to workHigh incidence of PTSD, depression, and caregiver burdenDelayed functional recovery and unmet expectationsPrognostic Factors and Predictive Markers Frailty as a key indicatorPre-existing mental health as a predictor of post-ICU mental health outcomesIn-hospital arrest characteristics: rhythm, downtime, comorbiditiesICU Follow-Up Clinics Value in knowledge translation and emotional supportReal-world insights on functional recovery and patient satisfactionCommon patient sentiment: gratitude mixed with traumaCommunication with FamiliesAvoiding value impositionEmphasizing trajectory over fixed timelines Balancing hope with realismRethinking Endpoints in Research Limitations of 28-day mortalityNeed for patient-centered, long-term functional outcomesTrajectory-based data over snapshot metricsKnowledge Translation as the InterventionEquipping clinicians and patients with realistic expectations Normalizing psychological responsesShaping future research directions around lived experience

    25 min

About

The Critical Care Commute Podcast is grateful for your ears, insights and feedback. In return its hosts- Peter Brindley and Leon Byker, two ICU doctors in Alberta, Canada- offer up knowledge and debate with some of the most qualified, interesting, enlightened and provocative folks in Critical Care Medicine, and beyond. We strive to keep it practical and concise. Like you, our overriding goal is to get better, do better and feel better.

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