Amy Lamotte on the Anti aging Effects of Spermidine Part 2 Biohacking Superhuman Performance

This episode is the second of a two-part series on Primeadine: a new healthy aging Spermidine supplement that is already getting rave reviews.  Spermidine is a potent polyamine, known for inducing autophagy or cellular renewal.  As we age, our bodies are getting slower and slower in the production of spermidine leaving us more reliant on exogenous sources be they food or supplementation. 
Supplementation with spermidine in humans has been shown to support cognition and heart health, balance hormones and improve hair growth and fullness (including eyelashes),  strengthening nails.  Spermidine also positively impacts five of the nine hallmarks of aging including: misfolded proteins (impaired proteostasis), epigenetic changes, mitochondrial dysfunction, stem cell dysfunction, impaired cellular communication.
Amy Lamotte is a fellow biohacker and in this episode, she shares her amazing hacks and simple and effective techniques that anyone can follow. We talk about the benefits of Spermidine, its mechanisms, and how it induces autophagy. She also shares about how she hacked her autoimmune disease, treating it and reversing it herself through diet, supplementation and testing. You shouldn’t miss this episode. Listen in!
 
Meet this week’s guest:
Amy Lamotte is the Managing Director of Vallotte Nutrigenomics Limited in Hong Kong. She is a clinical nutritionist and researcher specializing in personalized nutrition, nutritional biochemistry, nutrigenetics, and nutrigenomics. Other areas of interest include anti-aging, circadian biology, and the microbiome. She has a Master’s of Science in Human Nutrition (summa cum laude) from the University of Bridgeport and a J.D. from Yale Law School.



Key Highlights:
[13:38] The mechanisms of Spermidine
[06:05] What is autophagy and why is it important?  
[19:41] The influence of Spermidine levels in different age groups 
[22:12] Different factors and theories in dysregulation of spermidine
[25:07] Diet has a big effect on preventive healthcare
[26:50] The two great powerful combo - diet and supplements
[31:35] What are the best supplements to take and not to take?
[34:53] There are two types in human studies: epidemiological studies and clinical trials
[38:44] The human clinical study of spermidine and the after results
 
Linkage: 
Oxford Healthspan  (Use promo code BIONAT15 to save 15% off your order.)
 
Connect with Amy:
Instagram: @amylamotte
Linkedin: https://www.linkedin.com/in/amy-valley-lamotte-501676111/ 
Website: https://www.amylamotte.com/ 
 
Promo code:  Bionat15 for 15% off for your full order
To Try Primeadine: Primeadine.com
 
REFERENCES FROM PODCAST INTERVIEW: 
REVIEW ON DIETARY & GUT MICROBIOTA POLYAMINES 
Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019).  Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in  nutrition, 6, 24. 
EPIDEMIOLOGICAL STUDIES RE SPERMIDINE/POLYAMINES 
Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., ... & Madeo,  F. (2016). Cardioprotection and lifespan extension by the natural polyamine  spermidine. Nature medicine, 22(12), 1428-1438. 
Kiechl, S., Pechlaner, R., Willeit, P., Notdurfter, M., Paulweber, B., Willeit, K., ... & Willeit, J.  (2018). Higher spermidine intake is linked to lower mortality: a prospective population-based  study. The American journal of clinical nutrition, 108(2), 371-380. 
Pucciarelli, S., Moreschini, B., Micozzi, D., De Fronzo, G. S., Carpi, F. M., Polzonetti, V., ... &  Napolioni, V. (2012). Spermidine and spermine are enriched in whole blood of  nona/centenarians. Rejuvenation research, 15(6), 590-595 
Schwarz, C., Horn, N., Benson, G., Calzado, I. W., Wurdack, K., Pechlaner, R., ... & Flöel, A.  (2020). Spermidine intake is associated with cortical thickness and hippocampal volume in  older adults. NeuroImage, 221, 117132.