315 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

Paul Saladino MD podcast Paul Saladino, MD

    • Health & Fitness
    • 4.7 • 289 Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. I hope you’ll join me on this journey.

    250. When You Should Worry About LDL Cholesterol with Mike Fave

    250. When You Should Worry About LDL Cholesterol with Mike Fave

    Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia.



    *Produced by Mountain Valley Media



    00:06:08 Blood markers & imaging techniques of metabolic function 

    00:14:38 Gene mutations

    00:20:28 LDL & Plaque burden

    00:27:23 Money in statins

    00:31:38 Downsides of lowering LDL

    01:21:23 The downsides of popular cholesterol lowering drugs

    01:41:07 Should we fear heart attacks?

    01:45:23 PCSK9 Inhibitors

    01:52:43 Risk profile of Statins 

    01:53:02 Risk vs. reward of Ezetimibe

    02:04:02 Primary vs. secondary prevention



    Resources:

    Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast:

    https://www.youtube.com/watch?v=JcEmSgbMfco&t=2933s



    Work With Mike: https://mikefave.com/

    • 2 hrs 16 min
    249. Bloodwork Review: April 2024

    249. Bloodwork Review: April 2024

    This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.



    00:00:00 Podcast begins

    00:01:40 Traditional bloodwork 

    00:05:40 MTHFR polymorphism: Does Paul take supplements?

    00:10:10 Glucose & creatine

    00:14:10 Electrolytes & insulin

    00:23:10 Thyroid panel

    00:26:18 Cortisol to DHEA sulphate ratio

    00:32:20 Cholesterol panel

    00:46:10 Hormones & Other results

    00:50:20 Iron panel

    00:52:40 What bloodwork should you get?





    References:

    July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669s

    August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y

    December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c

    March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg





    DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc



    Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/



    Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/



    Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/



    The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/



    Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/



    Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y



    Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/



    Get your bloodwork from ultalabs.com

    • 58 min
    248. Why I Built a Food Company with Anthony Gustin

    248. Why I Built a Food Company with Anthony Gustin

    While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.



    Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt

    *Produced by Mountain Valley Media

    00:00:00 Podcast begins
    00:03:00 The devaluation of food preparation in modern society
    00:09:00 how supply chain issues contribute to poor food quality
    00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet
    00:28:47 Ads
    00:45:21 Why most “grass-finished” beef isn’t what you think it is
    01:05:09 Lineage Ad
    01:13:21 Paul’s beef with seafood
    01:21:20 Testing for PFAs
    01:25:17 What to expect from Lineage Provisions
    01:28:45 Answering FAQs about Lineage Provision’s meat sticks

    Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

    • 1 hr 41 min
    247. Gary Brecka: Tap Water is Lowering Your IQ!

    247. Gary Brecka: Tap Water is Lowering Your IQ!

    Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.



    *Produced by ⁠Mountain Valley Media



    00:00:00 Podcast begins

    00:01:23 What is fluoride and is it harmful?

    00:07:30 How to filter your water

    00:09:00 Western medicine & longevity

    00:27:00 Food sourcing and big food

    00:30:50 Cyanocobalamin

    00:34:55 Folic acid

    00:42:00 Gathering objective & subjective data

    00:49:00 The importance of gene testing & methylation

    • 1 hr 7 min
    246. Some things I'm experimenting with lately...

    246. Some things I'm experimenting with lately...

    On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.



    *Produced by ⁠Mountain Valley Media

    00:00:00 The importance of heart & riboflavin
    00:08:30 Pauls new company: Lineage
    00:10:50 Thoughts on creatine
    00:19:10 Paul’s experience with white rice & potatoes
    00:24:45 Paul experimenting with supplements for methylation

    Check out Lineage Meat Sticks: https://lineageprovisions.com/password

    References:
    Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

    • 30 min
    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    245. Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Lab Podcast

    This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.



    *Produced by ⁠Mountain Valley Media

    00:00:00 Podcast begins
    00:04:00 Mike’s background
    00:05:15 Diving into fructose
    00:13:00 Thoughts on honey and other carb sources
    00:27:30 Robert Lustig rebuttal: is fructose addictive?
    00:37:40 Fructose & fiber
    00:47:00 How fructose affects the mitochondria
    00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
    00:56:17 Is insulin the bad guy?
    01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
    01:23:30 Balancing protein, fat and carbohydrates
    01:30:00 Is fructose making us fat?
    01:46:00 Final thoughts


    Connect with Mike:
    Mikefave.com
    https://m.youtube.com/@MikeFaveSimplified


    References:
    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

    A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

    The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

    Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

    Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

    Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

    Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/

    Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/

    Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

    Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

    Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

    Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

    Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/

    Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

    • 1 hr 54 min

Customer Reviews

4.7 out of 5
289 Ratings

289 Ratings

Sandra GF ,

Review by getter_done 🇨🇦

Great Apple podcast, YouTube channel, Instagram channel & website. Excellent guests also.

DondelingerDA ,

Charlatan Alert

This guy does a poor job of backing his claims up with credible data. See @biolayne.

nbsluyyz ,

Lively and interesting

Really enjoyed the episode about how meat reverses aging - it was so good. I love when he debunks vegan and plant based propaganda with logic and studies.

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