9 episodes

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

Unlocking Bryson's Brain CBC Podcasts

    • Science
    • 4.3, 214 Ratings

Bryson is a beautiful, happy and loving boy. But a mysterious illness means he can’t walk, talk, or feed himself. After years without a diagnosis, even Bryson’s parents have come to accept that he may never be able to live independently. Then one day, everything changes. Scientists working at the cutting edge of genetics believe they know what’s causing Bryson’s disease — and think it could be reversed. Motivated by the hope for a cure, Bryson’s parents search for the miracle key that could unlock Bryson’s brain.

    Episode 8: Two Futures

    Episode 8: Two Futures

    After months of waiting, the “Bryson mouse” is finally ready for lab tests that will provide new insights into treatments and cures. And Bryson’s parents explore two possible versions of Bryson’s future.

    • 58 min
    Episode 7: Pilgrimage to Boston

    Episode 7: Pilgrimage to Boston

    Bryson’s parents travel to Boston/Cambridge, the global capital for rare disease research. Their goal: to ask private biotech companies to help in their search for a cure. Scientists provide new clues, but also raise difficult questions.

    • 40 min
    Episode 6: The Ethics of Cure

    Episode 6: The Ethics of Cure

    Finding a cure for Bryson no longer seems impossible. And that raises new questions about the ethics of this journey. Bryson’s family seeks out new perspectives and learns why “cure” is a loaded term in the disability rights community.

    • 49 min
    Episode 5: Making a Mouse

    Episode 5: Making a Mouse

    Scientists in Toronto get to work building a mouse with Bryson’s precise genetic variant. Plus, the family travels to Atlanta to provide blood samples for a researcher to create DNA-based “mini-brains” in his lab. Could this cutting edge science provide clues to unlocking Bryson’s brain?

    • 43 min
    Episode 4: A New Hope

    Episode 4: A New Hope

    Bryson’s family travels to meet other GRIN1 patients, including Bryson’s GRIN-twin Olivia. And research on mice offers new hope for finding a cure. But a new illness means that the family now needs two medical miracles.

    • 53 min
    Episode 3: The CRISPR Revolution

    Episode 3: The CRISPR Revolution

    Bryson’s parents explore CRISPR, a new technology with the potential to cure dozens of diseases once thought incurable. But gene editing comes with risks — not just for individual patients, but for the human race.

    • 33 min

Customer Reviews

4.3 out of 5
214 Ratings

214 Ratings

Whitneyda ,

So Good

This family is incredible.

I loved every single part of this series. All I kept thinking is there is such a huge theme of ‘love’ with this family - their ability to move through the highs and lows in such a vulnerable and graceful way and continue to keep searching for a cure was so beautiful to hear.

Thank you for making this podcast!

Nicky201020121015 ,

Really enjoyed listening

Thank you for sharing your story, sounds like Bryson has an amazing family!

Nora the explora👍 ,

😉

I hope you end up finding a cure. I think Bryson deserves it!

Top Podcasts In Science

Listeners Also Subscribed To