Disruptive Wyss Institute for Biologically Inspired Engineering

There are roughly 120,000 people in the United States on waiting lists for live-saving organ transplants, with only about 30,000 transplants happening every year. To address this great challenge of organ shortages, a team at the Wyss Institute led by Core Faculty member Jennifer Lewis, Sc.D., is developing a method for 3D bioprinting organ tissues with requisite vasculature for eventual organ transplant.

In this episode of Disruptive, Jennifer Lewis is joined by Wyss Institute Research Associate Mark Skylar-Scott, Ph.D., and former Wyss Institute Postdoctoral Fellow Kimberly Homan, Ph.D., to talk about the current status of their work, challenges they face, and the next steps in their path to 3D bioprint human organs.

In this episode of Disruptive, David Walt, Wyss Core Faculty member, discusses his lessons learned from founding successful biotech companies and how he incorporates translation-minded thinking early on into his current diagnostic research in his labs at the Wyss Institute and the Brigham and Women’s Hospital. Walt and collaborators are inventing new diagnostic tools to allow clinicians to better understand and treat some of the most pressing healthcare problems.

In this episode of Disruptive, Rob Wood, a roboticist and Core Faculty member at the Wyss Institute, and David Gruber, a marine biologist at Baruch College, discuss a chance encounter that led them to develop soft robotic tools that enable a new, non-invasive approach to interacting with deep ocean life.

In this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Staff Scientist Charles Reilly discuss their process creating The Beginning, a short film inspired by Star Wars, to better communicate science to the public…and how they made a scientific discovery along the way.

To make The Beginning, film industry visual effects and animation tools were used to merge scientific data from different disciplines, which enabled their team to create more accurate depictions and predictions of the natural world than what could otherwise be achieved. The team is now exploring how to use this approach to rational drug design and understanding the molecular mechanisms of disease.

Immunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researches are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease.

With 100 trillion cells in the human body, bacteria outnumber our own human cells 2 to 1. These bacteria make up one’s microbiome, and particularly bacteria in our guts affect all our key organ functions. They play a role in our health, development and wellness, including endurance, recovery and mental aptitude.

In this episode of Disruptive, Wyss Core Faculty member George Church and Wyss Postdoctoral Fellow Jonathan Scheiman discuss collecting and sequencing gut bacteria of elite athletes to produce customized probiotics - and the potential that these probiotics could give recipients access to some of the biological advantages that make those athletes elite.