Cosmetics have been in use for thousands of years. The absence of regulation of the manufacture and use of cosmetics, as well as the absence of scientific knowledge regarding the effects of various compounds on the human body for much of this time period, led historically to a number of negative adverse effects upon those who used cosmetics, including deformities, blindness and in some cases death. Examples of the prevalent usage of harmful cosmetics include the use of ceruse (white lead) throughout a number of different cultures, such as during the Renaissance in the West, and blindness caused by the mascara Lash Lure during the early 20th century.