The Proof with Simon Hill Live better for longer

Episode #320. Are you part of the 20% of people with this dangerous gene? There’s a cheap, simple test you can do just once in your life to find out. Join me as I sit down with renowned lipidologist Dr Thomas Dayspring to help you understand Lipoprotein(a) and the test that might change your life.
In this episode, you’ll learn what Lp(a) is and how it can affect your cardiovascular disease risk through two key pathways. Dr Dayspring unpacks why it’s so important to test, how to ask for this test, and what to do with your results.

Specifically, we discuss:

Introduction (00:00)

Demystifying Lipoprotein(a): An Overview of its Role in Cardiovascular Health (02:54)

Genetic Inheritance Patterns and Variability of Lipoprotein(a) (10:11)

Drug Development Strategies for Reducing Lipoprotein(a) Levels (14:50)

Exploring the Functional Role and Genetic Variations of Lipoprotein(a) (20:27)

Inside the Artery Walls: Mechanisms and Structure of Lipoprotein(a) (32:34)

A Deep Dive in Production to Measurement of Lipoprotein(a) (42:32)

Identifying High-Risk Indicators for Lipoprotein(a) (58:54)

Statins and Elevated Lipoprotein(a): Understanding the Relationship (01:11:42)

Exploring PCSK9 Inhibitors in Lipoprotein(a) Management (01:20:30)

Emerging Treatments and Future Therapies for Lowering Lipoprotein(a) (01:31:22)

Exploring Lifestyle Considerations and Alternative Therapies (01:34:42)

Oxidized Phospholipids and Their Role in Cardiovascular Health (01:43:15)

Relationship Between Oxidized Phospholipids and Lipoprotein(a) (01:52:00)

Understanding Aortic Valve Calcification and Its Link to Lipoprotein(a) (01:59:40)

Key Takeaways and Future Landscape of Lipoprotein(a) Treatments (02:06:52)

Conclusion and Final Remarks (02:13:30)


Connect with Dr Thomas Dayspring on Twitter/X. Listen to our previous lipid series and download the cheat sheet here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #319. Join me today as I sit down with a very special guest: my dad, Professor Michael Hill, PhD. Dad’s journey as a scientist has inspired my own work and taken our family across the globe, and I’m honoured to host him as he shares his story from early career discoveries to current research.
As well as getting an inside look at Dr Hill’s academic career, you’ll learn about microvasculature (very small blood vessels), including what they are and how they impact human health. Dad also shares his experience with a heart attack, offers advice on preventing atherosclerosis, and weighs in on the Ozempic and vaping conversations.

Specifically, we discuss:

Introduction (00:00)

Childhood Memories and Early Interests (03:19)

Pursuing a Career in Biochemistry (08:36)

Microvasculature and Diabetes Research (12:12)

Early Research on Investigating Blood Properties and Diabetes (17:44)

Family Stories and Moving to the U.S. (28:47)

Returning to Australia and Continued Research (36:39)

Exploring Microvessel Behaviours: Research at RMIT (41:34)

Dealing with Health Challenges and Maintaining Work-Life Balance (46:20)

Understanding Microvascular Functions and Cardiac Health (50:32)

Exploring Vessel Constriction and Small Blockages: A Closer Look (01:00:15)

Understanding the Impact of Large Arterial Stiffness on Vascular Health (01:07:01)

Identifying Risk Factors: A Comprehensive Approach to Vascular Well-being (01:11:01)

Personal Views on the Evolution of Scientific Research Access (01:19:39)

Returning to the USA: Advancing Research on Blood Vessel Mechanisms (01:21:58)

COVID-19 and Metabolic Syndromes: Exploring the Early Research Connections (01:27:30)

Current Research and Future Directions (01:29:29)

Reflecting on a Career Dedicated to Science: Family, Achievements, and Future Directions (01:34:48)


If you’re interested in learning more about Dad’s work and career, head to his profile here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.
Shopify
Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants

Episode #318. 50,000 women. 30 years of follow-up. The results of a new study are in: learn the truth about how your protein intake will affect your long-term health. What kind of protein should you consume? How much? And what difference will it really make on longevity?
Today, I’m unpacking the results from the new study in the American Journal of Clinical Nutrition, “Dietary protein intake in midlife in relation to healthy aging - results from prospective Nurses' Health Study cohort”.
This new study from researchers at Harvard University and Tufts University has been regularly misinterpreted online, and in this episode, I’ll set the facts straight. Learn the three most important protein takeaways from this study, hear my take on Layne Norton’s interpretation, and crack the code to using protein as a tool for healthy aging.

Specifically, I cover:

Introduction to Protein and Longevity (00:00)

Study Overview and Methodology (01:24)

Key Findings on Protein Sources (05:33)

Lane Norton's Review and Critique (06:38)

Analysis of Different Protein Types (10:02)

Practical Recommendations for Protein Intake (17:13)

Conclusion and Final Thoughts (21:34)


If you’re interested in the Danish Dietary Guidelines, you can find them in English here.

This episode is brought to you by:
38TERA
Consider 38TERA's DMN-01 prebiotic supplement a daily multivitamin for your gut. Formulated by yours truly and gastroenterologist Dr Will Bulsiewicz. Use code THEPROOF for a discount at checkout.
Eimele
Eimele Essential 8 is a comprehensive multivitamin that is scientifically formulated to complement your plant-rich diet, increase and sustain your energy, and support the immune system, as well as heart and brain health. Head to Eimele.com and use code SIMON at checkout for 10% off your first order.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com.
WHOOP
Whoop, the most advanced fitness and health wearable available. Your personalised fitness and health coach to recover faster, sleep better, and train smarter. Claim your first month free on join.whoop.com/simon.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #317. Are you neglecting your social health without realising it? We know connection is the often-forgotten pillar of wellbeing and longevity – but how much of a difference does it truly make to your physical and mental health? More than you might think. Join me as I sit down with Kasley Killam, a leading expert in social health, to discover the science behind why relationships are so critical to our well-being.
In this episode, Kasley Killam paints a comprehensive picture of the importance of social health and how you can foster it. You’ll learn how connection affects physical and mental health, what good social health is, and how to achieve it. We also discuss what to do about difficult relationships, how to build a strong relationship with yourself, and how to fit intentional connection into a busy schedule.

Specifically, we discuss:

Introduction to Kasley Killam and Her New Book (00:00)

What is Social Health? (03:11)

The Importance of Social Health (06:17)

Mechanisms Linking Social Health and Physical Health (11:04)

Practical Tips to Boost Your Social Health (16:48)

Overcoming Challenges & Misconceptions About Social Health (20:44)

Personal Practices and Experiments (22:29)

Building and Assessing Social Health (34:32)

The Decline of Friendships and Social Health (44:32)

Impact of Technology on Social Connections (47:10)

Work Trends and Social Health (49:11)

Public Health and Social Health Innovations (50:12)

Fostering Social Health in the Corporate World (54:11)

Decode Your Social Health Style (01:00:37)

Self-Compassion and Building a Relationship with Yourself (01:15:04)

Envisioning a Socially Healthy Future (01:22:08)

Conclusion and Final Thoughts (01:23:37)


Head to https://www.kasleykillam.com/ to learn more about Kasley Killam’s work and purchase her new book, The Art and Science of Connection. Connect with her on Instagram, Twitter/X, and LinkedIn, and subscribe to her newsletter here.

This episode is brought to you by:
InsideTracker
If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.
Eimele
Use code SIMON at checkout for 10% off your first order.
38TERA
Use code THEPROOF for a discount at checkout.
WHOOP
Claim your first month free on join.whoop.com/simon.

Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants

Episode #316. Overeating is not your fault. But it is in your control – just not in the way you might think. Learn how to overcome food addiction in this conversation with psychiatrist, neuroscientist, and self-mastery expert, Dr Jud Brewer.
Learn Dr Brewer’s secret to gaining control over your eating habits (and no, it’s not willpower). Discover why we overeat, the reason you can’t break bad habits, and how to take back your power over food as we unpack the science of behavioural change.

Specifically, we discuss:

Introduction: Understanding the Brain and Habit Formation (00:13)

Key Elements of Habit Formation (02:55)

The Brain's Role in Decision-Making and Habit Change (10:02)

The Impact of Awareness and Mindfulness on Habit Change (14:58)

Analysing Eating Habits and the Food Environment (24:35)

Survivorship Bias in Successful Habit Change (27:36)

Emotional Eating and Coping Mechanisms (31:17)

Addressing Guilt, Shame, and Systemic Failures (36:24)

Environmental Influences on Eating Patterns (41:18)

Breaking Negative Eating Habits: Weight Loss Journey (49:00)

Effective Strategies to Stop Destructive Habits: Breathwork (58:53)

The Role of Psychedelics and Meditation in Overcoming Negative Eating Habits (1:01:24)

How the Brain Changes When We Modify Eating Habits (1:04:36)

Pharmacology vs. Mindfulness: Which Is More Effective? (1:07:57)

Practical Tips to Overcome Night Cravings (1:19:10)

Measuring Success in Habit Change (1:28:50)

Debunking the 21-Day Habit Formation Myth (1:34:51)

Conclusion and Final Thoughts (1:35:54)


Connect with Dr Jud Brewer on Instagram, Twitter/X, YouTube, and Threads. Learn more about Dr Brewer on his website, https://drjud.com/, where you can also order his latest book, The Hunger Habit.

This episode is brought to you by:
InsideTracker
If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon.
Sun Home Saunas
Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase.
Momentous
My go-to supplement brand for protein and creatine is Momentous. Get 36% off subscriptions, and 20% off one-off purchases, by using the code LIVINGPROOF at checkout at livemomentous.com
Cozy Earth
Sleep better and cooler with Cozy Earth, the softest science-backed sheets on the market. With a 10-year warranty, 100-day trial period, and ethical production, Cozy Earth is my favourite easy way to improve my rest and recovery. Use code SIMON at cozyearth.com for up to 35% off.
Eimele
Use code SIMON at checkout for 10% off your first order.
38TERA
Use code THEPROOF for a discount at checkout.
WHOOP
Claim your first month free on join.whoop.com/simon.
Want to support the show?
The best way to support the show is to use the products and services offered by our sponsors. To check them out, and enjoy great savings, visit theproof.com/friends. You can also show your support by leaving a review on the Apple Podcast app and/or sharing your favourite episodes with your friends and family.
Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of The Proof is in the Plants
Watch the episodes on YouTube or listen on Apple/Spotify
Connect with me on Instagram, Twitter, and Facebook
Nourish your gut with my Plant-Based Ferments Guide
Download my complimentary Two-Week Meal Plan and high protein Plant Performance recipe book

Episode #315. What is ApoB and why should you care? In this latest instalment of our masterclass series, I’ve distilled the essential insights about apolipoprotein B (ApoB) into one informative episode. Join top experts including Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho as they unravel the significance of ApoB as a crucial marker of cardiovascular health. This episode provides a thorough understanding of why ApoB matters and how it impacts your health.
We unpack the essentials of ApoB, covering its role in cholesterol transport and why it's a key marker for heart disease risk. You'll learn how ApoB affects cardiovascular health, from the way it modifies LDL particles to its impact on atherosclerosis and longevity. We discuss the best ways to measure ApoB, its normal levels, and what causes it to rise. The episode also explores the relationship between ApoB and saturated fats, and why it's a more reliable risk marker than LDL cholesterol. By the end, you'll have a clear understanding of why ApoB matters for your heart health and how it can help guide better health choices.

Specifically, we discuss:

Introduction (00:00)

Lipoproteins & Cholesterol: Transport and Recycling (00:43)

Cholesterol's Role in Lipoproteins (26:40)

Is ApoB a More Accurate Marker of Cardiovascular Risk? (31:13)

Endothelial Transcytosis of Lipoproteins (39:42)

LDL Modification and Aggregation (49:17)

Evidence for ApoB's Role in Atherosclerosis (55:49)

ApoB and Genetics (58:29)

ApoB and Longevity (1:02:16)

Mechanisms Behind Elevated ApoB Levels (1:05:14)

Why ApoB is the Best Predictor of Cardiovascular Disease (1:08:52)

ApoB vs LDL-Cholesterol: Understanding the Discordance (1:21:00)

Healthy ApoB Levels for Young Adults (1:31:39)

Causes of Elevated ApoB Levels (1:45:16)

Target ApoB Levels for Cardiovascular Disease Prevention (2:04:31)

The History and Evolution of the Lipid Hypothesis (2:07:27)

Role of ApoB Lipoproteins in Atherosclerosis (2:10:21)

Importance of ApoB as a Cardiovascular Risk Marker and Its Clinical Application (2:18:39)

Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:27:47)

Top Saturated Fat Foods That Increase Cardiovascular Risk (2:33:53)

Impact of Saturated Fat on ApoB and Cardiovascular Disease (2:35:49)

Dietary Changes to Lower ApoB Levels (2:38:59)

Outro (2:45:54)


Read more about the guests featured on this episode or connect with them on their respective pages on The Proof website: Dr Thomas Dayspring, Dr William Cromwell, Danny Lennon, Dr Alan Flanagan, and Dr Gil Carvalho.

This episode is brought to you by:
InsideTracker
If you want to improve your health, you need to measure where you’re currently at. InsideTracker analyses up to 48 blood biomarkers including ApoB, LDL, HDL, A1C, and more before giving you advice to optimise your health. Get a 20% discount on your first order at insidetracker.com/simon.
BON CHARGE
Enhance skin health, increase collagen production, and reverse sun damage with BON CHARGE, my choice of low-level light therapy. Holistic, evidence-based, premium products for healthier skin. Get started at boncharge.com and use code THEPROOF for a 15% discount.
Shopify
Shopify, the world's leading e-commerce platform, helps you turn browsers into buyers with the internet’s best-converting check out–up to 36% better compared to other leading e-commerce platforms. To boost your conversion rate, and grow your business, sign up for a one-dollar-per-month trial period at shopify.com/proof.
Sun Home Saunas
Invest in your body and mind with Sun Home Saunas, pioneers in crafting premium saunas and cold plunges. Safe, effective, research-backed wellness tools to improve cardiovascular health, offer psychological benefits, and reduce muscle soreness. Head to sunhomesaunas.com/theproof for $300 off your purchase.

Simon Hill, MSc, BSc (Hons)
Creator of theproof.com and host of The Proof with Simon Hill
Author of