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SDBN BUZZ is the San Diego Biotechnology Network podcast, connecting the local life science community through trending topics and thoughtful conversations.

SDBN BUZZ sdbnbuzz

    • Firmengründung

SDBN BUZZ is the San Diego Biotechnology Network podcast, connecting the local life science community through trending topics and thoughtful conversations.

    Using Biology as Technology to Stream Data

    Using Biology as Technology to Stream Data

    Michael Heltzen is the CEO of Cardea Bio. He envisions a time when biology is part of the technology. What exactly does that mean?
    We currently use aspects of biology to observe or manipulate living systems. But often we are measuring at a moment in time. His vision is to use biological molecules as sensors to continuously stream information through electrical signals much as a transistor works in a computer, communicating on and off states of binding interactions for example.
    As an analogy, it would be difficult to understand soccer from a collection of still photos. But watching a broadcast of a full game, one would have a better understanding of the rules and the objectives. 
    He described for me the work they have done so far using graphene as the basis for this new technology.
    We switched gears in the last part of our conversation. Michael explained why he chose San Diego over the Bay Area as the home for his business.

    • 34 Min.
    The Fleet Science Center Mission Goes On Even in a Pandemic

    The Fleet Science Center Mission Goes On Even in a Pandemic

    As we shelter in place in the midst of a pandemic, the world waits for science to rescue us with testing, treatments and/or a vaccine. But how do we get more people to connect with the power of science on a regular basis?
    That's the mission of The Fleet Science Center. Steve Snyder is the CEO of "The Fleet" and was kind enough to join me and describe how that mission is executed even as the center itself is closed due to shelter in place orders.
    What you may not know is that there are programs throughout the county ongoing all the time.
    One of the themes is letting the audience drive the conversation - meeting them where they are. What do people want to know? As opposed to "Here's what you need to know about X."
    The conversation drives home the need for science communication. A highlight is the program, "Two Scientists Walk Into a Bar..." where once a month 2 scientists are available at about 25 bars and breweries around town just to talk about whatever they might be curious about.
    Wouldn't it be great if every kid growing up knew a scientist? Steve thinks that, in San Diego, it's possible. And imagine what kind of transformation could happen if we stopped actively excluding more than half the population from participating in science. Steve shared a story of how that is still happening and how we can change that.
    The Fleet Science Center
     

    • 33 Min.
    Avoiding Business Disaster

    Avoiding Business Disaster

    Many business disasters are the result of bad decision making. But how do we learn to make better decisions, given all the effort that goes into planning, SWOT analyses and so on?
    Gleb Tsipusky has been studying this for a long time. He focuses on cognitive bias, the tendency for our brains to push us in one direction that seems right when we really should be taking a bigger look around.
    In this episode, Gleb gives examples of decision making gone bad and points out the different biases that resulted in those decisions. He also lays out some techniques for assembling teams and evaluating our own thinking to avoid those mistakes.
    Not surprisingly, he has written a book on the subject:   Never Go With Your Gut: How Pioneering Leaders Make the Best Decisions and Avoid Business Disasters 

    • 27 Min.
    Participating in the San Diego Angel Conference - Peter Teriete

    Participating in the San Diego Angel Conference - Peter Teriete

    Back in November, I spoke to Mysty Rusk and Jason Scharf about the upcoming (now complete) San Diego Angel Conference.
    In this episode, Peter Teriete describes his experience as a participant. His company, TumorGen, enrolled in the conference looking for funding and guidance. They made the semi-finals, but as Peter points out, you don't need to be the eventual winner to have a good outcome. Many of the companies will find investors along the way.
    I asked Peter what he learned about running his business as well as what he learned about pitching it. His positive attitude comes through throughout the interview.
    I strongly encourage all entrepreneurs to listen to this episode and then share it with your community.
    Feel free to connect with Peter on LinkedIn.

    • 29 Min.
    Using Zebrafish to Discover Host Directed Therapies

    Using Zebrafish to Discover Host Directed Therapies

    Infectious disease is getting a lot of attention right now because we are in the middle of the Corona Virus pandemic. In this episode (recorded back in January),  Dr. Molly Matty helps us explore how Zebrafish, a model organism for development is being used to investigate host pathogen interactions, specifically with Mycobacterium marinum. 
    Other species of Mycobacterium cause tuberculosis or leprosy in humans, of course. Molly explains the benefits of the zebrafish model for potentially identifying host derived therapies for Mycobacterial diseases.
    In particular, zebrafish:
    Can be engineered with fluorescently labeled vasculature and macrophages
    Readily absorb small molecules (like antibiotics)
    Are transparent as larvae and embryos
    All of which make them amenable to direct observation of pathogen interactions under a microscope.
    Bonus: Molly explains how to inject a live zebrafish without a mask and snorkel.
     
    Learn more at: mollymatty.com
    Connect on Twitter: @ooomollypop
     

    • 27 Min.
    Founder Mentality - From Imposter Syndrome to Quiet Confidence

    Founder Mentality - From Imposter Syndrome to Quiet Confidence

    Self doubt and the expectations of others can be a heavy load to carry. Debbie Chen, Founder and CEO of Hydrostasis, managed to relieve herself of those burdens and finally discover what success means to her. 
    Debbie arrived from Taiwan at the age of six. She got a PhD (much later) because she wanted to make her parents proud. She never had her own definition of success until recently. Starting a company wasn't on her list of things to do. She didn't think she could for many reasons.
    She has found her success and makes a point to give back so others can share it.
    In this interview she describes:
    Making the leap from scientist to CEO
    What it means (and what to do) when you're told, "You're too early."
    How she developed patience and got comfortable with waiting
    Why she recommends therapy for all startup founders
    The one habit that helps her sleep better every night
    Her best advice for entrepreneurs from underrepresented groups
    Whether you are a founder, a woman, a minority or just busting your butt at work (Debbie is all of those) you will find something here you can use. This is one of my all time favorite interviews.

    • 42 Min.

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