We're not getting any younger... yet‪.‬ The Buck Institute

Of all the biochemical changes that occur with aging, what really matters? How can we use the incredible amount of health data available today to discover the best targets for interventions? In this episode, Kristen Fortney of BioAge talks with Gordon about the latest research in proteomics and metabolomics, the importance of muscle loss, and the challenge of measuring the right endpoints for effective treatment and regulatory approval.Kristen Fortney is the co-founder and CEO of BioAge, a cl...

What is the relationship between diet, chronic disease, and aging? Can we delay or reverse the effects of aging at the cellular level by following a fasting-mimicking diet? Listen in as Gordon speaks with Valter Longo of the Longevity Institute at USC about epigenetic reprogramming, turning on Yamanaka factors, and restoring our cells to a youthful state based on over 30 years of research on diet and fasting.Dr. Valter Longo is the Edna M. Jones Professor of Gerontology and Biological Science...

Our modern world is full of potential disruptions to sleep. But as we learn more about circadian rhythm, we find that it influences everything from metabolism to mental health in different ways as we age. In this episode, Satchin Panda of the Salk Institute guides Gordon through the many interactions between sleep behavior and biology. Together they explore how new insights can help us improve our sleep health, and how researchers might target circadian rhythm to modulate the effects of aging...

What is the goal of living longer? It’s not simply to celebrate a number, but to do something meaningful with that time. Renowned Stanford psychologist Laura Carstensen speaks with Gordon about the experience of aging, in the past and in the future, and why changes in culture must accompany changes in healthspan so we can flourish as a society.Laura L. Carstensen is Professor of Psychology at Stanford University where she is the Fairleigh S. Dickinson Jr. Professor in Public Policy and foundi...

We're back! In season one, we investigated the biology of aging in many different organisms to learn why and how we age. This season we'll take a close look at potential interventions that modify mechanisms of aging biology and may dramatically change the way we age in our lifetimes.Get ready for season two of the Buck's podcast We're not getting any younger... yet. with scientist Gordon Lithgow. Subscribe today!Support the Show.

Gordon and Stella revisit key concepts from the conversation with Arne Akbar, such as using sestrins to modulate T-cells and telomeres. Looking back over the course of season one, Stella and Gordon discuss the need to think about aging as an organizing principle, and how to deal with all the things we don't yet know.Stay tuned for season two!Support the Show.