The Nourish Balance Thrive podcast is designed to help you perform better. Christopher Kelly, your host, is co-founder of Nourish Balance Thrive, an online clinic using advanced biochemical testing to optimize performance in athletes. On the podcast, Chris interviews leading minds in medicine, nutrition and health, as well as world-class athletes and members of the NBT team, to give you up-to-date information on the lifestyle changes and personalized techniques being used to make people go faster – from weekend warriors to Olympians and world champions.
You Literally Bled for That Data. Now What?
It’s been about three years since NBT began using supervised machine learning to predict the results of more expensive or unattainable biomedical tests. With our bloodsmart.ai software, we can forecast infections and inflammation, xenobiotic and heavy metal toxicity, and metabolic health indicators like fatty liver and elevated insulin - all without directly testing these markers. As a result, we’ve dramatically shifted our clinical work away from direct testing, instead focusing on basic blood chemistry and supervised machine learning to guide decision making. It's one of the things I'm proudest of building.
Sometimes I get asked how bloodsmart.ai compares to other blood chemistry programs. I used the other programs for years before coding my own, and rather than ML, they use what I call “hand-rolled algorithms.” For example, if alkaline phosphatase is low, then it must be a zinc deficiency. Unfortunately, biology is way more complicated than that, and supplementing with zinc with just one indicator never helps.
On this podcast, my Scientific Director Megan Hall and I are discussing how to interpret the forecast on a bloodsmart.ai report and how we use the results in our work with clients. We talk a little about how the algorithms work under the hood and how we know the forecasts have predictive value. We also explain what might be going on when the forecasts don’t match direct testing.
To get the most out of this podcast, be sure to follow along with Megan’s outline.
Here’s the outline of this podcast with Megan Hall: [00:04:39] bloodsmart.ai software.
[00:04:47] Supervised machine learning.
[00:06:36] Pain as the amazing protectometer; Video: Pain, the brain and your amazing protectometer - Lorimer Moseley.
[00:08:25] Karl Friston.
[00:09:38] eLife podcast and eLife Journal.
[00:10:06] Machine learning in embryology: Bormann, Charles L., et al. "Performance of a deep learning based neural network in the selection of human blastocysts for implantation." Elife 9 (2020): e55301.
[00:12:16] Machine learning for identifying prostate cancer: Hood, Simon P., et al. "Identifying prostate cancer and its clinical risk in asymptomatic men using machine learning of high dimensional peripheral blood flow cytometric natural killer cell subset phenotyping data." Elife 9 (2020): e50936.
[00:13:18] Podcast: How to Interpret Your White Blood Cell Count with Megan Hall.
[00:14:38] Paper: Wood, Thomas R., et al. "An interpretable machine learning model of biological age." F1000Research 8.17 (2019): 17.
[00:14:53] Podcast: How to Measure Your Biological Age, with Megan Hall.
[00:15:24] How do we know the models have skill? Article: A Gentle Introduction to k-fold Cross-Validation.
[00:17:40] What the forecasts are and what they’re not.
[00:19:18] A "cloudy crystal ball".
[00:23:21] Using bloodsmart.ai forecasts in clinical practice.
[00:24:25] Book: How to Decide: Simple Tools for Making Better Choices, by Annie Duke.
[00:26:17] The “Archer's Mindset”: The value of taking aim.
[00:28:09] Podcast: Environmental Pollutants and the Gut Microbiome, with Jodi Flaws, PhD.
[00:28:45] Article: How to do better at darts and life.
[00:32:33] Health history and symptoms; Health Assessment Questionnaire (HAQ) (example).
[00:35:30] 7 minute analysis.
[00:36:53] bloodsmart.ai bar chart (example).
[00:37:56] Food journaling.
[00:42:27] Environmental Working Group’s Skin Deep and Healthy Living App; Think Dirty Shop Clean App.
[00:43:03] Podcast: Air Pollution Is a Cause of Endothelial Injury, Systemic Inflammation and Cardiovascular Disease, with Arden Pope, PhD.
[00:44:23] Titanium bottle kickstarter: Keego.
[00:46:04] Discrepancies between forecast and directly measured marker.
[00:48:42] Forecasts that tend to be seen together.
[00:53:34] Forecast detail view (example).
Health Coaching: How to Get Trained and Build a Business
My guests today are certified Primal Health Coaches Laura Rupsis and Erin Power. Both maintain successful private practices while training others through Mark Sisson’s Primal Health Coach Institute (PHCI) and collaborating as hosts of the Health Coach Radio podcast. As the admissions director for PHCI, Laura is also behind the friendly voice you’ll reach when you’re seeking information about training as a health coach.
On this podcast Laura, Erin and I are talking about becoming a health coach: the training, the clients, and strategies for growing a successful practice. We look at some of the recent developments in the field, including national board certification and the new PHCI Level 2 Certification Course, recently introduced to meet the board requirements. We also discuss finding your niche, getting clients, and a realistic timeline for building a coaching business.
Here’s the outline of this interview with Laura Rupsis and Erin Power: [00:02:26] Mark Sisson.
[00:01:20] Erin's health journey.
[00:03:02] Laura's health journey.
[00:10:43] Simon Marshall, PhD and triathlete Lesley Paterson; Values Guided Actions Worksheet.
[00:12:47] Podcast: The Community Cure: Transforming Health Outcomes Together, with James Maskell.
[00:16:07] Do you need a credential to be a health coach?
[00:19:21] Information does not cause change.
[00:20:29] National Board for Health and Wellness Coaching (NBHWC).
[00:23:48] Primal Health Coach Level 2 Certification Course.
[00:31:07] Getting clients as a health coach, finding your niche.
[00:40:25] Dr. Jade Teta, women's hormone specialist.
[00:45:51] Building your coaching practice.
[00:48:55] Getting traffic; problems with Facebook.
[00:51:06] Superhuman email interface.
[00:52:44] Is health coaching scalable?
[00:54:36] Toastmasters for public speaking.
[00:57:43] Primal Health Coach Institute; Book a call with Laura; Facebook, Instagram.
[00:58:19] Health Coaching Success Virtual Masterclass; Enroll here.
[00:58:40] Health Coach Radio podcast.
The Community Cure: Transforming Health Outcomes Together
Author, speaker and entrepreneur James Maskell is passionate about healthcare transformation. He is the co-founder of the Functional Forum, the world’s largest integrative medicine conference. He lectures internationally, and has been featured on TEDMED, Huffpost Live, TEDx and more, and is a contributor to Huffington Post, KevinMD, thedoctorblog and MindBodyGreen. He also serves on the faculty of George Washington University’s Metabolic Medicine Institute.
On this podcast, James discusses the importance of disrupting the current state of medicine and accelerating its future. He describes his goal to empower clinicians to transition to a functional medicine model and to become leaders and change agents toward healthcare that is preventative and sustainable. We also talk about the importance of community and it’s critical role in avoiding chronic illness.
Here’s the outline of this interview with James Maskell: [00:01:34] Living in a commune in Colorado.
[00:03:16] Book: The Community Cure: Transforming Health Outcomes Together, by James Maskell.
[00:05:00] Podcast: Free to Learn: Unleashing the Instinct to Play, with Peter Gray, PhD.
[00:08:10] Making functional medicine the standard of care.
[00:10:05] Functional Forum.
[00:10:43] Problems with scaling up functional medicine.
[00:15:19] Solving the problem of loneliness.
[00:15:50] Video: George Slavich, PhD: How Much Does Social Stress and Isolation Affect Health?
[00:19:23] Book: Loneliness: Human Nature and the Need for Social Connection, by John T. Cacioppo & William Patrick.
[00:20:30] Nuclear families as the current norm.
[00:20:45] Book: The Story of the Human Body: Evolution, Health, and Disease, by Daniel Lieberman; “dysevolution”.
[00:25:44] Book: The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous, by Joseph Henrich.
[00:30:32] Organizing health coaches and the value of groups.
[00:35:35] Simon Marshall, PhD and world champion triathlete Lesley Paterson.
[00:37:19] Podcasts featuring Julian Abel, MD: Building Compassionate Communities to Improve Public Health and Maintaining Social Connection in the Era of COVID-19.
[00:37:31] How a practitioner can start utilizing groups.
[00:41:28] Autoimmune Protocol (AIP); Mickey Trescott at Autoimmune Wellness; Podcast: The Nutrient-Dense Kitchen: Applying the Autoimmune Protocol.
[00:42:14] Health sharing systems.
[00:46:00] Knew Health health sharing; Liberty Health Share.
[00:48:46] Evolution of Medicine; The Community Cure; Instagram.
How to Interpret Your White Blood Cell Count
There’s a common misconception that you need to run expensive advanced biomedical tests to fix your health. Over the years we’ve found just the opposite, that you can learn much of what you need to know from basic blood chemistry. Perhaps the best example is the information gained from a Complete Blood Count (CBC) with Differential. As the most common blood test, it is widely used to assess general health status, screen for disorders, and to evaluate nutritional status.
On this podcast, NBT Scientific Director Megan Hall and I are talking about leukocytes, also known as white blood cells (WBCs), as critical elements of the CBC blood test. Megan discusses the various types of leukocytes and what it means when your count is outside the reference range. We talk about what leukocytes tell you about your nutritional status, why some people “never get sick” as well as signs you’ve got chronic inflammation or physiological stress. Megan also discusses how to use this information to determine the next steps in your health journey.
Here’s the outline of this interview with Megan Hall: [00:01:04] Forum post: Chronically Low White Blood Cell Count. Get access when you support us on Patreon.
[00:01:45] Leukocytes = White Blood Cells (WBCs) found on CBC with differential blood test.
[00:02:58] Different types of white blood cells.
[00:04:18] Phagocytosis video.
[00:06:10] Absolute vs relative counts of WBCs.
[00:09:15] Optimal range of WBCs in relation to all-cause mortality.
[00:11:25] Baltimore Longitudinal Study on Aging: Ruggiero, Carmelinda, et al. "White blood cell count and mortality in the Baltimore Longitudinal Study of Aging." Journal of the American College of Cardiology 49.18 (2007): 1841-1850.
[00:12:57] Study: Shah, Anoop Dinesh, et al. "White cell count in the normal range and short-term and long-term mortality: international comparisons of electronic health record cohorts in England and New Zealand." BMJ open 7.2 (2017): e013100.
[00:18:00] Why WBCs might be high: Leukocytosis.
[00:18:45] Paper: WBCs are predictive of all cause mortality: Crowell, Richard J., and Jonathan M. Samet. "Invited commentary: why does the white blood cell count predict mortality?." American Journal of Epidemiology 142.5 (1995): 499-501.
[00:20:00] Podcast: Air Pollution Is a Cause of Endothelial Injury, Systemic Inflammation and Cardiovascular Disease, with Arden Pope, PhD.
[00:21:57] Association of leukocytosis with metabolic syndrome; Study: Babio, Nancy, et al. "White blood cell counts as risk markers of developing metabolic syndrome and its components in the PREDIMED study." PloS one 8.3 (2013): e58354.
[00:22:15] Megan's outline for this podcast.
[00:22:41] What to do if you have elevated WBC counts.
[00:22:54] Impact of stress; Studies: 1. Nishitani, Naoko, and Hisataka Sakakibara. "Association of psychological stress response of fatigue with white blood cell count in male daytime workers." Industrial health 52.6 (2014): 531-534. and 2. Jasinska, Anna J., et al. "Immunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)." Scientific reports 10.1 (2020): 1-12.
[00:23:32] Dr. Simon Marshall and Lesley Paterson; Podcast: How to Manage Stress, with Simon Marshall, PhD.
[00:24:08] Reasons WBC counts might be low; Leukopenia.
[00:27:57] "I never get sick".
[00:30:40] What to do if your WBCs are low.
[00:30:56] Effects of low energy availability: Studies: 1. Johannsen, Neil M., et al. "Effect of different doses of aerobic exercise on total white blood cell (WBC) and WBC subfraction number in postmenopausal women: results from DREW." PloS one 7.2 (2012): e31319. and 2. Sarin, Heikki V., et al. "Molecular pathways mediating immunosuppression in response to prolonged intensive ph
How to Have Intimacy With Ease
Jessa Zimmerman, MA is a licensed couples counsellor and nationally certified sex therapist based in Seattle, Washington. She specializes in helping couples who find that sex has become stressful, negative, disappointing, or pressured. In her practice, she counsels and supports couples through an experiential process that allows them real-world practice in changing their relationship and their sex life. She is also the author of the book, Sex without stress; a
Male Optimization: How to Keep Your Edge as you Age
Returning to the podcast today is speaker, NY Times bestselling author, coach, and lifelong athlete Brad Kearns. Decades removed from his status as a #3 world-ranked pro triathlete, Brad has now turned his attention to broader fitness goals aligned with healthspan. Always finding new ways to challenge himself, In 2018 Brad broke the Guinness World Record for the fastest single hole of golf ever played, and this year he ranked #1 in the USA and #3 in th