70 épisodes

Genetic Engineering & Biotechnology News (GEN) has retained its position as the premier biotech publication since its launch in 1981. GEN publishes a print edition monthly and has additional exclusive editorial content online, including news and analysis as well as webinars, videos, and polls. GEN's unique news and technology focus covers the entire bioproduct life cycle, including drug discovery, early-stage R&D, applied research (e.g., omics, biomarkers, and diagnostics), bioprocessing, and commercialization.GEN's print magazine, which also can easily be accessed online, includes feature articles on emerging technologies, product roundups, in-depth overviews from key scientific and bioindustry meetings, and industry-standard tutorials and technical articles on drug discovery, bioprocessing, and assay technologies.
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GEN Podcasts Genetic Engineering and Biotechnology News

    • Technologies

Genetic Engineering & Biotechnology News (GEN) has retained its position as the premier biotech publication since its launch in 1981. GEN publishes a print edition monthly and has additional exclusive editorial content online, including news and analysis as well as webinars, videos, and polls. GEN's unique news and technology focus covers the entire bioproduct life cycle, including drug discovery, early-stage R&D, applied research (e.g., omics, biomarkers, and diagnostics), bioprocessing, and commercialization.GEN's print magazine, which also can easily be accessed online, includes feature articles on emerging technologies, product roundups, in-depth overviews from key scientific and bioindustry meetings, and industry-standard tutorials and technical articles on drug discovery, bioprocessing, and assay technologies.
Hosted on Acast. See acast.com/privacy for more information.

    Emerging Markets Collaborate to Succeed in Post-Pandemic World

    Emerging Markets Collaborate to Succeed in Post-Pandemic World

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    • 18 min
    Breathing Oxygen Back into the Biological Conversation

    Breathing Oxygen Back into the Biological Conversation

    As good scientific investigators, we strive to make our research more reproducible, repeatable, and translatable. These traits are ostensibly engrained in researchers from the start of their careers but often fall to the wayside in pursuit of experimental answers. Throughout this three-episode podcast series, sponsored by The Baker Company, we will weave the common thread of these essential research traits and discuss some ubiquitous techniques common to so many laboratories—focusing on areas that are often overlooked but can have a considerable impact on recapitulating physiological conditions and the efficacy of your experiments. So tune in to this first podcast where we discuss the importance of oxygen biology in common lab experiments.
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    • 19 min
    Global Single-Use Network Supports Assurance of Supply

    Global Single-Use Network Supports Assurance of Supply

    Single-use systems have been steadily climbing toward the top of the tools utilized by biomanufacturers for the commercial-scale production of critical therapeutic products. However, COVID-19 created an inflection point for this technology, generating an even greater demand that will shape the market for many years. Yet, with considerable demand comes the need to focus on the key aspects driving growth while discovering the appropriate solutions to the challenges that invariably arise when technologies are being developed and utilized rapidly.
    This is our third and final episode of GENcast, where Dr. Ger Brophy, the Executive Vice President of Biopharma Production at Avantor, joins me. We sat down to discuss several essential facets of single-use systems and some ways to help manage risk and decrease the intricacies most often associated with single-use supply chains. Make sure you check out episode one and episode two for more in-depth discussions with Dr. Brophy.

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    • 27 min
    Resins Address Downstream Purification Concerns

    Resins Address Downstream Purification Concerns

    The demand for safe and efficacious biologics has accelerated exponentially in the past several years due to the tremendous success of some of the initial therapeutic offerings in this space. Yet, along with this increased demand comes the need for innovative solutions to improve downstream production workflows. For example, eliminating purification bottlenecks and improving overall yields from chromatography steps can significantly impact the final product’s cost.
    In this second episode of GENcast with Executive Vice President of Biopharma Production at Avantor, Dr. Ger Brophy, we dive into some of the challenges biomanufacturers face during downstream purification and how addressing the traditional thinking surrounding chromatography resins, and buffers can be highly advantageous and immensely cost-effective. Take a listen to episode 2 below, and if you want to check out episode 1, click here!

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    • 20 min
    Materials Sourcing: Precautions and Improvements for Cell and Gene Therapies

    Materials Sourcing: Precautions and Improvements for Cell and Gene Therapies

    The success and applications of cell and gene therapies are seemingly limitless, and economic forecasts project a compound annual growth rate of almost 40% over the next eight years. This rapid expansion is a double edge sword for biomanufacturers of cell and gene therapy products. On the one hand, the tremendous growth is excellent for business. Yet, on the flip side, biomanufacturers are faced with solving the numerous challenges of scaling-up production workflows: from raw material sourcing to supply chain management to adopting new and innovative production modalities. Having a trusted global partner that can help organizations navigate the tumultuous bioprocessing waters of cell and gene therapy production is advantageous and often the key to continued success in the space.
    In this GENcast, we sit down with the Executive Vice President of Biopharma Production at Avantor, Dr. Ger Brophy, to discuss some of the precautions and improvements for cell and gene therapies and how manufacturers can address many of the challenges they face. Take a listen!

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    • 21 min
    Mechanistic Modeling Improves Drug Discovery Workflows and Speeds Therapeutic Development

    Mechanistic Modeling Improves Drug Discovery Workflows and Speeds Therapeutic Development

    This is the final episode in our three-part GENcast series, where we discuss the virtues of mechanistic modeling and how it can significantly impact critical decision-making points in the drug discovery process, especially as drug developers move closer toward the IND process. In our two previous podcasts, we were introduced to mechanistic modeling concepts and the basics of how they can be applied to drug discovery workflows. You can listen to the earlier podcasts with the following links: episode 1, episode 2. In this latest GENcast, I met up once again with Dr. John Burke, President, CEO, and Co-founder of Applied BioMath, to discuss the specific applications of mechanistic modeling, especially concerning the process of deciding the first human dose numbers, and how his company is helping biotech and pharma organizations reduce their late-stage drug attrition rates. Take a listen!
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    • 23 min

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