Hema Now: Advancing Care in Myelofibrosis

In this episode of Hema Now, we take a deep dive into myeloproliferative neoplasms (MPN), with a particular focus on myelofibrosis, one of the most complex and challenging MPNs to manage. Ciro Rinaldi discusses what distinguishes myelofibrosis from other chronic MPNs, the biological drivers of disease progression, and the critical role of inflammation and the bone marrow microenvironment. The conversation also explores emerging combination therapies, translational research hurdles, and how the management of myelofibrosis may evolve over the next decade.

Timestamps:

00:00 – Introduction

00:59 – Myeloproliferative neoplasms

04:00 – Myelofibrosis

09:58 – Ciro's interest in the field

13:39 – Disease drivers & progression to aggressive states

17:40 – Inflammation and the bone marrow environment

22:19 – Novel targets

27:45 – Splenomegaly and MPNs

32:19 – Translational research

36:25 – Future of myelofibrosis management

38:51 – Ciro's three magic wishes