Solving the Puzzle with Dr. Datis Kharrazian

Datis Kharrazian, PhD, DHSc, DC, MS, MMSc, FACN
  • 5.0 (13)
  • Health & Fitness
  • Updated weekly

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.  His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

  1. 1 day ago

    Episode 90: GSM Essentials for 2025: Top Treatment Updates, Safety Guidance, and Patient Impact

    In this episode, Jillian Moehle focused on the latest evidence-based strategies for recognizing and treating Genitourinary Syndrome of Menopause (GSM). She explored newly updated guidelines from the American Urological Association, emphasizing the importance of proactive screening, a comprehensive approach to patient history, and the range of therapeutic options available, from non-hormonal treatments like moisturizers and lubricants, to hormone-based therapies including low-dose vaginal estrogen. Several points were raised, including safety considerations, the removal of the FDA black box warning on vaginal estrogen, and the crucial role of pelvic floor health in patient outcomes. Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause 00:00 Vaginal treatment recommendations and concerns 05:26 Discussing hormone therapy alternatives 08:13 Treatment options for vaginal health 13:16 FDA removes black box warning 15:24 Support for vaginal estrogen use 18:13 Using GoodRx and applying cream 22:00 Possible side effects and management 24:54 Impact of GSM on women's health 30:59 Podcast outro and resources sharing Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    32 min

  2. 2 Jun

    Episode 89: Why Millions of Women Were Failed by the Women’s Health Initiative Study

    In this episode, we’re diving into the complex and often misunderstood topic of menopause and perimenopause. Despite affecting every woman who lives into late life, menopause has long been underfunded, understudied, and minimized both culturally and medically. Today, we’ll explore why clinical care for women in the menopause transition has lagged behind, examining the deep historical roots of gender bias in research, the fragmentation of women's healthcare, and the profound impact of the Women’s Health Initiative (WHI) study, which triggered decades of fear and misinformation about hormone therapy.  Enroll now in: Under-Recognized, Under-Treated, and Misrepresented Realities of the Perimenopause and Menopause Transition, with Leslie Fuller, ND and Jillian Moehle, ND at https://pages.kharrazianinstitute.com/fuller-moehle-perimenopause 00:00 Historical oversight in menopause care 06:00 Women's Health Initiative study flaws 08:29 Impact of WHI study miscalculation 10:28 Misinterpretation of breast cancer risks 13:44 Correcting hormone therapy myths 17:23 Podcast resources and educational courses Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    19 min

  3. 28 May

    Episode 88: Hormone Therapy, Breast Cancer, and Menopause

    In today's episode, Dr. Mark Holthouse dives into the fears surrounding breast cancer and hormone replacement therapy, separating myth from evidence with a critical look at the real data. Our expert speaker unpacks the latest clinical trials and position statements, clarifying the nuanced relationship between various hormone therapies and breast cancer risk. We’ll explore what the research says about synthetic versus bioidentical hormones, address common patient concerns, and provide actionable insights for risk assessment and individualized care.  This episode delivers an integrative approach to hormone therapy and breast cancer, bridging the gap between scientific literature and real-world practice.  To enroll in the Sex Steroid Optimization Master Class with Dr. Mark Holthouse, go to https://pages.kharrazianinstitute.com/holthouse-hormone To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  00:00 WHI study on hormone therapy 04:45 Hormone therapy risks discussion 07:58 Discussing natural vs synthetic HRT 13:11 Transdermal hormone therapy studies 17:55 Rethinking full-fat dairy for women 21:11 Time restricted eating for women 22:57 Assessing breast cancer risk 25:30 Understanding genetic risk factors 29:37 Evaluating breast cancer risk factors Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    32 min

  4. 20 May ·  Bonus

    Episode 87: Clinical Strategies for Tackling Fatigue Through Mitochondrial Health

    In today’s episode, we dive into the “clinical faces of fatigue.” Join Datis Kharrazian as we explore why some individuals never fully recover from illnesses or injuries, the intricate link between mood and brain energy, and why two patients with similar medical conditions like anemia can have vastly different experiences of fatigue. We’ll unravel how mitochondrial dysfunctions, both inherited and acquired, lie at the heart of chronic fatigue, depression, fibromyalgia, and other conditions often resistant to simple solutions. You’ll discover why bagfuls of supplements aren’t enough, and how real recovery requires understanding and addressing the unique bioenergetic roadblocks each patient faces, ranging from oxidative stress and poor sleep to blood sugar imbalances and exposure to environmental toxins. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  00:00 Factors affecting mitochondrial function 03:55 Optimizing patient bioenergetics basics 09:27 Mitochondria and cell evolution 12:33 Focus on acquired mitochondrial dysfunctions 14:23 Mitochondrial ATP production process 20:22 Ketogenic diet and energy pathways 21:15 Ketogenic diet for chronic fatigue 27:02 Exploring functional medicine resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    28 min

  5. 5 May

    Episode 86: Oral and Injectable Peptides for Recovery

    In this episode, functional medicine clinician Dr. Rajka Milanovic Galbraith dive into the world of peptides for recovery, exploring both oral and injectable options. She breaks down the latest clinical insights on popular peptides like BPC157, KPV, Lorazatide, TB4, and PeptiStrong, sharing case studies and practical strategies for supporting gut health, autoimmune recovery, muscle maintenance, and post-injury healing. Whether you're a healthcare practitioner, a certified nutritionist, or simply looking for ways to optimize your health, this episode bridges complex science with practical solutions you can implement today.  Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Benefits and side effects of oral bpc 04:37 Addressing complex digestive issues 08:35 Managing gut inflammation 11:53 Using Pepti Strong for healing 15:15 Discussing growth hormone peptides 17:55 Growth hormone and cognitive function 20:38 Recognizing and managing drug reactions 26:00 Using peptides for post-op recovery 29:11 Podcast outro and resources Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    30 min

  6. 29 Apr

    Episode 85: Transforming Autism Care with Nutrigenetics and Methylation Pathways

    In this episode, Rajka Milanovic Galbraith, MD, dives into nutrigenetics and its transformative impact on mental health and chronic conditions. Using real-life patient stories, Dr. Galbraith illustrates how genetic insights and targeted nutrient support can unlock profound change. We’ll explore personalized approaches from thought leaders like Amy Yasko, Ben Lynch, William Walsh, and Bob Miller, discussing practical protocols for methylation, balancing minerals, and managing inflammation.  Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Balancing neurochemicals in children 04:16 Starting folate and B12 supplementation 07:00 Discussing William Walsh's approach 10:41 Understanding methylfolate tolerance 15:31 Patients help promote our practice 18:54 Genetic mutations and food sensitivity 23:19 Learning about methylation pathways 23:58 Evaluating a child's diet and genes 29:56 Discussing toxic exposures and genetics 31:06 Podcast resources and final thoughts Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    32 min

  7. 21 Apr

    Episode 84: Exploring Oxidative Stress, GST Genes, and Hormonal Detox Strategies

    In this episode, we dive into the world of oxidative stress, GST gene patterns, and hormone genetics, uncovering how these factors influence chronic illness and overall health. You'll hear about innovative testing strategies, gene patterns seen in chronically unwell patients, and real-world case studies that illustrate the practical steps clinicians can take to restore health and balance. Whether you're a healthcare professional seeking to advance your knowledge or an individual looking to understand the science behind fatigue, hormone imbalance, and detoxification, this episode bridges the gap between complex genetics and actionable solutions.  Enroll now in: Precision Protocols Unlocked: Guide to Nutrigenetics & Peptide Mastery, with Rajka Milanovic Galbraith, MD ⚡ Learn to integrate genetics, micronutrients, and peptides into patient care. 📅 May 23, 2026 🌐 https://pages.kharrazianinstitute.com/galbraith-peptides 00:00 Identifying high hydrogen peroxide symptoms 03:06 Addressing brain fog and fatigue 08:11 Combating jet lag with supplements 12:01 Understanding hormone breakdown genetics 13:36 Finasteride side effects and solutions 19:18 Importance of Selenium and Zinc 21:10 Initial treatment and Dutch test results 25:50 Podcast resources and disclaimers 26:53 End of the episode reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    27 min

  8. 14 Apr

    Episode 83: The Functional Anatomy of Pain

    In this episode with Dr. Datis Kharrazian, we dive into the mechanisms that underlie pain, exploring key terms like nociception, hyperalgesia, allodynia, and sensitization. You'll learn how pain signals travel through first, second, and third order neurons, why some injuries result in referral pain, and how chemical mediators and the sympathetic nervous system amplify pain perception. We’ll break down how the brain interprets, localizes, and emotionally responds to pain, revealing the roles of the somatosensory cortex, amygdala, insular cortex, and other regions. Discover why pain isn’t always proportional to tissue damage and how psychological and physiological variables, including mood and limbic system activation, shape your experience. Whether you're a healthcare professional, nutritionist, or someone managing chronic pain, this episode bridges scientific insight with practical understanding, helping you see pain from a whole new perspective. Register for Chronic Fatigue and Pain Syndromes Clinical Strategies and Treatment Applications at https://pages.kharrazianinstitute.com/chronic-fatigue-and-pain-syndromes To become a Certified Functional Medicine practitioner, visit https://kharrazianinstitute.com/⁠. Try our 7-day free trial, no credit card required.  ⁠ For Certified Functional Nutrition education for both practitioners and lay people, visit https://afnlm.com/⁠ 00:00 Understanding types of pain 04:57 How mood affects pain perception 08:02 Why visceral pain feels external 12:04 How pain signals are amplified 15:58 How pain is blocked 19:44 How the brain processes pain 22:12 Understanding central pain syndromes 26:01 Explaining brain pathways for pain 30:06 Podcast outro and resources 31:09 Closing message and reminder Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

    31 min
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Ratings & Reviews

5
out of 5
13 Ratings

About

Solving the Puzzle with Dr. Datis Kharrazian is based on more than 20 years of Dr. Kharrazian's experience working with autoimmune and brain health patients throughout the U.S. and Europe, exhaustive review of the scientific research, and protocols he has innovated through trial and error in working with complex patient cases. Dr. Kharrazian discusses evidence-based models incorporating diet, nutrition, and lifestyle — protocols hard won through decades of working with tough, complex patient cases.  His goal is to help teach you effective models for so-called “mystery” symptoms and conditions so you can regain control of your health and life. Hashimoto's: Solving the Puzzle, is a new online course from Dr. Kharrazian, who is the originator of evidence-based strategies for managing autoimmune Hashimoto's hypothyroidism. This course has the most complete and current information for managing Hashimoto's available. You can find more information at drknews.com. Support this show http://supporter.acast.com/solving-the-puzzle-with-dr-datis-kharrazian. Hosted on Acast. See acast.com/privacy for more information.

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