- S&K Double Take Podcast
- S-Rank Gaming Podcast
- S.P.C.A.C. (Seriously Pointless Conversations About Culture)
- S.T.B The Podcast With Amp The Blerd
- S.W.E.T OPS Debriefing
- Sachman
- Sacred Icon: A Halo Podcast
- Sacred Symbols: A PlayStation Podcast
- Sadistic Gamer Podcast
- SADPP w/ Bowie & Zyori
- Sae Bae Cast
- Saetas
- Safe Room
- SAFE ROOMS de Reseteando Podcast
- Safespace Helden
- Saga Podcast
- Saga Podcast Season 1
- Sagacité
- Sagan om Isfolket - Podden
- Sagaz
- SAGE WORLD
- Sagittarius Eye Podcast: Elite Dangerous' leading news network
- Saint seiya Gods y Batalla final
- Saint Virtual
- Saints 3G Podcast
- SakaTalks
- SAL8-Bit
- Salazar's Saladbar
- Salotto Nerd
- Salotto Pikavee
- Salsa nos seus Jogos - Podcast em Áudio
- Salt Cast: The stories behind Rocket League Esports
- Salt City Gamescast: A Video Game Podcast
- Salt Happens
- Salty Snacks Podcast
- Saltycast
- Salvaje Podcast
- Salvando NPCs
- Salvando Tempo
- Salve Time - Podcast
- Sam's Side
- Samcast
- SamdotEXE
- Same SkyCast
- Same Type
- Sams Life
- Samuel’s radio show
- Sandbox
- Sandys Brawl Podcast
- Sandys Podcast
- Sandys Sleepy Podcast
- Sanity Optional
- Sans Connection Gamescast
- Sans Jeu Vidéo Fixe
- Sapos y Culebras
- SARA Podcast
- Sargos Sector Radio
- SASA44
- Sass Effect
- Satellcast's Podcast
- Satire Gaming Nation
- Saturday Morning Arcade
- Saturday Morning Gaming Show
- Saturday Morning Podcast
- Saturday Night PML
- Saturday Nights with Athalus: Warcraft's Original Radio Show
- Saturdays Are For The Boys
- Saucy Specials
- Saudi DGA podcast
- Saulitomikett
- Saure Gurken Army
- SavageNami
- Save And Continue Podcast
- Save Continue Podcast
- Save Data Cast
- Save File
- Save File Corrupt
- Save File!
- SAVE GAME
- Save Point
- Save Point Podcast
- Save Point Sessions
- Save Rotation
- Save Scum: Every Video Game Can Save Your Life
- Save State Podcast
- Save Station Radio
- Save Your Game
- Saved Game
- SavePoint
- Savepoint Radio
- SavePoint | Despertar Nerd
- Savepunkt Radio
- SaveState - The Level Save Podcast
- SAVORN
- Sawyer, Kev, and Matt Minecraft Chat
- Say It In Red
- Sayonara Podcast
- SBA Central News
- SBCGaming Podcast
- SBRReports
- SC2GG Podcast
- Scampgrounds
- Scandalous Games
- SCANLINES podcast
- Scarcast
- Scarlett
- Scart
- Scary Stories
- ScarzzCast
- Scatter Cast
- Scatterbrained
- Scav Talk
- Scene World – The C64 NTSC/PAL Disk Magazine – Podcast
- SceneSkips
- Scet's Corner
- Schawarma & Spiele
- Scheggia di Mithril
- Schlechte Gamer
- Schlechter Umgang
- Schmucks Podcast
- Schnabeltier Fancast
- Schnack Pack - Tech, Games und mehr
- Scholars of the IX Lore Podcast
- Schundcast (schundkritik.de)
- Scikids
- SCLoreCast's podcast
- Scooby Doo Central
- Scorch Radio
- SCORE CAST
- Scotch N' Games
- ScotchGaming Podcast
- Scott and Paul Show
- Scottish Games Network Podcast
- Scotto Presents: Cheat Code Visa
- Scouting4Games Podcast
- SCP 096 talk
- Scp On-site Radio Prerecording 1
- Scp tape to tape
- SCPodcast
- ScramPunks Podcast
- Scratched Disc Podcast
- Scratching the Itch
- Screen Bytes
- Screen Looking
- Screen Peakers Video Game Podcast
- ScreenPlayers Videogames Podcast
- Screenshot - Mediapodcast
- ScreenWatchers Podcast
- Script Lock
- Scrivere di Videogiochi
- Scrollin'
- Scrubs vs the World Podcast
- ScrubVerse Podcast
- Scruffed up
- ScubaCast
- Scythe and Shield: Rebirthed Podcast
- Se ta' jugando | Podcast
- Se7en Pillars
- Sea Bears Orga
- Sea Of Friends
- Sea of Friends: Your Weekly Sea of Thieves Voyage
- Sea Of Theives
- SEAG - Sempre Escolhia a Gostosa
- SeamusNation
- Sean & Jason Show
- Sean G.'s Podcast
- Search & Report
- Search for Obsidian
- SearchingForPixels - Having A Chat With...
- Season 1 Podcast
- Season 1 SubZero Podcast
- Season Three Podcast
- Seasonal Anime Checkup OVA
- Seasonn!ck
- Sebas ps
- Sebsgaming
- Second Player - Interviews With Gaming Podcasters, YouTubers
- Second Screen
- Secret Gamer Podcast
- Secret Levels
- Secret Stage - Nerd Culture News
- SecretBosses Podcast
- Secretos y Conspiraciones
- Secrets Of Lego Universe
- Secrets Of The League
- Secrets of the Scrolls: An Elder Scrolls: Legends Podcast
- SECTOR 01
- Sector 7 - El Podcast retro de IGN España
- Sector Gamer - EDM Radio
- Sector Gaming
- Sector.sk
- Sed de Conocimiento
- See No Evil
- See What Sticks - A Variety Podcast
- Seeing It Through
- Seen On Screen Podcast
- Sega Addicts AM
- SEGA AGES
- SEGA Generations
- SEGA Legacy
- Sega Mega Drive Mini Battle
- SEGA Mixer Drive
- Sega Saturn, SHIRO!
- SEGA Sunrise
- SEGAbits Swingin' Report Show : SEGA News and Interviews
- SEGAzices
- Segwasted
- Seinen Summit
- Select BGM
- Select Characters Podcast.
- Select Difficulty Podcast
- Select Game
- Select Game Podcast from theLogBook.com
- Select Start Podcast
- Select y Start · Entretenimiento
- Select Your Game
- SelectCast
- SelectStartPodcast
- Selfless Gamers - Dylan, Josh, Kevin, Matthew
- Selfmade with Nadeshot
- Sellout
- Seltzer on the Sticks
- Sem Controle Show
- Sem Queda De Fps
- Sem Roteiro Podcast
- Semanario del Otaku
- Semantics
- Semi-Casual Podcast with Chaide & Obbi
- Semi-Informed Games
- SEMIGAMERS
- Semilla de Videojuegos
- Semper Ludo's Incredible Podcast
- SEMPOBUILD
- Sensações Nerds
- Sensei Pongcast | Video Game Book Club
- Sentimental Sundays
- Seputar Mobile Legends
- SequelTalk with Mitch & Friends
- Ser Gamer É Bom Demais
- Ser o Estar