Paul Saladino MD podcast Paul Saladino, MD

This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.



00:00:00 Podcast begins

00:01:40 Traditional bloodwork 

00:05:40 MTHFR polymorphism: Does Paul take supplements?

00:10:10 Glucose & creatine

00:14:10 Electrolytes & insulin

00:23:10 Thyroid panel

00:26:18 Cortisol to DHEA sulphate ratio

00:32:20 Cholesterol panel

00:46:10 Hormones & Other results

00:50:20 Iron panel

00:52:40 What bloodwork should you get?





References:

July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669s

August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y

December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c

March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg





DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc



Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/



Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/



Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/



The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/



Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/



Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y



Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/



Get your bloodwork from ultalabs.com

While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.



Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt

*Produced by Mountain Valley Media

00:00:00 Podcast begins
00:03:00 The devaluation of food preparation in modern society
00:09:00 how supply chain issues contribute to poor food quality
00:17:50 Why it’s so hard to raise pork and chicken on their ancestral diet
00:28:47 Ads
00:45:21 Why most “grass-finished” beef isn’t what you think it is
01:05:09 Lineage Ad
01:13:21 Paul’s beef with seafood
01:21:20 Testing for PFAs
01:25:17 What to expect from Lineage Provisions
01:28:45 Answering FAQs about Lineage Provision’s meat sticks

Buy Lineage Beef Sticks: https://lineageprovisions.com/products/classic-meat-sticks

Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.



*Produced by ⁠Mountain Valley Media



00:00:00 Podcast begins

00:01:23 What is fluoride and is it harmful?

00:07:30 How to filter your water

00:09:00 Western medicine & longevity

00:27:00 Food sourcing and big food

00:30:50 Cyanocobalamin

00:34:55 Folic acid

00:42:00 Gathering objective & subjective data

00:49:00 The importance of gene testing & methylation

On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.



*Produced by ⁠Mountain Valley Media

00:00:00 The importance of heart & riboflavin
00:08:30 Pauls new company: Lineage
00:10:50 Thoughts on creatine
00:19:10 Paul’s experience with white rice & potatoes
00:24:45 Paul experimenting with supplements for methylation

Check out Lineage Meat Sticks: https://lineageprovisions.com/password

References:
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C-T polymorphism: https://pubmed.ncbi.nlm.nih.gov/16380544/

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.



*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins
00:04:00 Mike’s background
00:05:15 Diving into fructose
00:13:00 Thoughts on honey and other carb sources
00:27:30 Robert Lustig rebuttal: is fructose addictive?
00:37:40 Fructose & fiber
00:47:00 How fructose affects the mitochondria
00:51:00 Clarifying hyperglycemia vs. a postprandial hyperglycemia
00:56:17 Is insulin the bad guy?
01:12:20 How insulin relates to diabetes, obesity, and insulin resistance
01:23:30 Balancing protein, fat and carbohydrates
01:30:00 Is fructose making us fat?
01:46:00 Final thoughts


Connect with Mike:
Mikefave.com
https://m.youtube.com/@MikeFaveSimplified


References:
Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

A High-Fat Meal, or Intraperitoneal Administration of a Fat Emulsion, Increases Extracellular Dopamine in the Nucleus Accumbens: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4061790/

A Relationship between Reduced Nucleus Accumbens Shell and Enhanced Lateral Hypothalamic Orexin Neuronal Activation in Long-Term Fructose Bingeing Behavior: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988143/

The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents: https://journals.physiology.org/doi/full/10.1152/ajpendo.00165.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

Consumption of Raw Orange, 100% Fresh Orange Juice, and Nectar- Sweetened Orange Juice—Effects on Blood Glucose and Insulin Levels on Healthy Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770506/

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

The Effects of Soluble Dietary Fibers on Glycemic Response: An Overview and Futures Perspectives: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9736284/#B37-foods-11-03934

Formation of Fructose-Mediated Advanced Glycation End Products and Their Roles in Metabolic and Inflammatory Diseases: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227984/

Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM: https://pubmed.ncbi.nlm.nih.gov/9216960/

Glucagon and type 2 diabetes: the return of the alpha cell: https://pubmed.ncbi.nlm.nih.gov/25344790/

Insulin, growth hormone and sport: https://pubmed.ncbi.nlm.nih.gov/11431133/

Effect of Mild Physiologic Hyperglycemia on Insulin Secretion, Insulin Clearance, and Insulin Sensitivity in Healthy Glucose-Tolerant Subjects: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881846/

Fructose metabolism in humans – what isotopic tracer studies tell us: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533803/

Absorption capacity of fructose in healthy adults. Comparison with sucrose and its constituent monosaccharides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1433856/

Review article: fructose malabsorption and the bigger picture: https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2006.03186.x

Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice: https://pubmed.ncbi.nlm.nih.gov/19637282/

Fructose Promotes Leaky Gut, Endotoxemia and Liver Fibrosis through CYP2E1-Mediated Oxidative and Nitrative Stress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783321/

On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.



*Produced by ⁠Mountain Valley Media



00:00:00 Podcast begins

00:02:50 Brad’s weight loss journey

00:10:50 The human metabolism

00:15:10 How olive oil makes us fat

00:34:24 Deep dive into European diets

00:48:50 PREDIMED trial comparing different types of olive oil

00:51:05 De novo lipogenesis (DNL)

00:53:50 What happens when humans eat canola oil

00:59:20 A story about the Inuit & long-term ketosis

01:07:20 Takeaways about olive oil



Connect with Brad:

https://www.youtube.com/@fireinabottle3410



References:

Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence



Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004



OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/



Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/



Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext



Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/