13 episodes

Interviews and highlights from the 2016 BACR meeting.

BACR 2016 ecancer

    • Medicine

Interviews and highlights from the 2016 BACR meeting.

    • video
    Surrogate endpoint biomarkers in research

    Surrogate endpoint biomarkers in research

    Dr Bonanni speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about "window of opportunity" trials which gauge pre-surgical patient responses to treatments against breast cancer.

    He describes the range of medicines and dietary compounds which have shown chemopreventive activity, and how surrogate biomarkers can be brought to broader clincal application.

    • 5 min
    • video
    Chemoprevention of platelet crosstalk in cancer

    Chemoprevention of platelet crosstalk in cancer

    Prof Patrono speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about the action of COX1 in preventing colorectal cancer.

    Platelet activation, stimulated by COX1, results in angiogenesis which supports tumoural development.

    Prof Patrono also describes how platelets may form a physical barrier around tumours, and how aspirin can directly obstruct a serine residue essential for platelet function.

    • 5 min
    • video
    Societal barriers to chemoprevention

    Societal barriers to chemoprevention

    Dr Censi speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about the hurdles facing adoption of chemopreventative strategies.

    He highlights the lack of monetary and emotional investment in prevention compared to diagnosis and treatment of cancers, and the uncertainty surrounding clinical data due to the lengthy timeline of studies.

    Dr Cesni also considers the regulatory issues of off-brand prescription and repurposing of drugs, compared to the widespread public acceptance of food supplements, and the incorporation of preventative behaviours into screening and counselling.

    • 10 min
    • video
    The future of cancer prevention

    The future of cancer prevention

    Prof Cuzick speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about the future of cancer prevention.

    With the example of tamoxifen in breast cancer, he describes the need for research and advocacy in chemoprevention to advance current understandings of aspirin, metformin and as-yet-unidentified factors that could reduce the likelihood of cancer in populations.

    • 5 min
    • video
    COMMD1 pathway activated by aspirin restores apoptosis in colorectal cancer

    COMMD1 pathway activated by aspirin restores apoptosis in colorectal cancer

    Dr Stark speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about the mechanism by which aspirin can prevent colorectal cancer.

    Having isolated the NFkB pathway, which is inhibited by aspirin via upregulation of COMMD1, Dr Stark describes how apoptosis in colorectal tumour tissues could inspire further cancer treatments.

    • 4 min
    • video
    Drug repurposing in review

    Drug repurposing in review

    Dr Khanim speaks with ecancertv at the 2016 BACR and ECMC Joint Meeting about drug repurposing topics discussed at the conference, from ongoing trials to patient advocacy.

    She also describes her work with the ECMC UK therapeutic cancer prevention network, a professional group whose focus lies in advocacy and research towards the licencing of chemopreventative medicine.

    • 3 min

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