New Books in Science New Books Network

If you're interested in memory, you'll find a lot in Memory Makes the Brain: The Biological Machinery That Uses Experiences To Shape Individual Brains (World Scientific, 2021), from cellular processes to unique and interesting perspectives on autism.

Detailed descriptions of cellular processes involved in forming a memory.

Connecting those cellular processes to everyday experiences - like the memorable image of a butterfly seen during a hike decades ago.

Comparisons of plasticity in different brain areas, like cortex, hippocampus, cerebellum.

Comparisons of plasticity and learning in different phases of the human life.

Important milestones in the history of neuroscience. Like Wiesel and Hubel's work identifying the critical period for plasticity, or Huttenlocher's discovery of synaptic pruning.

Up-to-date science and open questions about autism, a wide range of phenomena that seems to be connected both to synaptic pruning and to the funtion of the cerebellum.

An outlook on non-synaptic plasticity.


Professor Christian Hansel starts both the book and the conversation with establishing a very broad definition of memory. Traditionally, a lot of research focused on the "observable outcome" of learning: acquiring new skills, changing behavior. Instead, he defines memory as any event that changes the brain.
The first 2 chapters introduce major discoveries from the 1960s and 1970s. David Hubel and Thorsten Wiesel examined the visual system of kittens. They recognized that it's much more adaptive in a "critical period", ca. 4-8 weeks after birth. Peter Huttenlocher discovered another fascinating phenomena during childhood: synaptic pruning. In the years 2-12, a lot of synapses (connections between neurons) disappear.
Chapter 3 describes the molecular machinery behind all these observations. We'll get to know the terms LTP (long-term potentiation) and LTD (long-term depression), which mean the long-term strengthening and weakening of synaptic connections respectively. We find a detailed description of these processes, incl. the enzymes, neurotransmitters and receptors contributing to them.
Chapter 4 continues examining these processes across the human life span. The (perhaps surprising) conclusion: The machinery for synaptic plasticity is quite similar in a small child an in an adult. What's different is the magnitude of these processes.
Autism is a central topic both in the book and in the Hansel Lab's work. Chapter 5 starts with describing the difficulties of a definition. ASD (autism spectrum disorder) is an umbrella term encompassing several symptoms and intensities. In the last years, it has turned out that low degree of synaptic pruning plays a significant role in multiple forms of autism. We'll see in the next years how the research about synaptic pruning and learning can be used for clinical purposes. Understanding the biological mechanism can also make it easier to relate to some peculiar-sounding symptoms. If we consider that an individual's brain contains an unusually high number of synapses, their reports about unusually intense perceptions suddenly become more understandable.
A thought-provoking chapter is number 6. It describes various experiments with mouse models to study autism-like symptoms. The chapter might also make you reflect about the merits and shortcomings of animal models generally.
The cerebellum was long considered to be the brain area for finetuning movements. Now, it's clear that its repertoire is much bigger. In the interview, Christian describes a hypothesis that the cerebellum has a capability of timing. This in turn makes it a crucial factor in several behaviors beyond sophisticated movements, including speech.
We know a lot about synaptic plasticity and its significance in learning. Chapter 8 tackles the big, open question, what else? Which other processes contribute to memory formation? It presents some hypotheses about intrinsic plasticity.
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A new understanding of memory is emerging from the latest scientific research. In Why We Remember: Unlocking Memory's Power to Hold on to What Matters (Doubleday, 2024), pioneering neuroscientist and psychologist Charan Ranganath radically reframes the way we think about the everyday act of remembering. Combining accessible language with cutting-edge research, he reveals the surprising ways our brains record the past and how we use that information to understand who we are in the present, and to imagine and plan for the future.
Memory, Dr. Ranganath shows, is a highly transformative force that shapes how we experience the world in often invisible and sometimes destructive ways. Knowing this can help us with daily remembering tasks, like finding our keys, and with the challenge of memory loss as we age. What's more, when we work with the brain's ability to learn and reinterpret past events, we can heal trauma, shed our biases, learn faster, and grow in self-awareness.
Including fascinating studies and examples from pop culture, and drawing on Ranganath's life as a scientist, father, and child of immigrants, Why We Remember is a captivating read that unveils the hidden role memory plays throughout our lives. When we understand its power-- and its quirks--we can cut through the clutter and remember the things we want to remember. We can make freer choices and plan a happier future.
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Most of us appreciate the importance of the immune system yet have very little knowledge about how it actually works. If you fall into this camp and are curious to learn more about this intricate system, Bobby Cherayil's book is an excellent resource.
The Logic of Immunity: Deciphering an Enigma was published in January 2024 by John Hopkins University Press. It gives a great overview of this complex system, including several findings from the recent years. It also points out the many areas of ongoing research and open questions.
The book introduces the actors of the system and the many interactions between them:

the various types of immune cells,

the pathogens and pathogen-associated patterns they recognize,

the cascade of events that ultimately leads to an immune response.

The opening chapter explains (and visualizes!) where these cells are located. It explains how they contribute to the immune response, and how we broadly categorize them into innate and adaptive immunity.
Chapters 2 and 3 discuss the innate immune system. We get to know the general concepts, like molecular patterns and receptors recognizing them. They describe in detail some well-studied mechanisms, like the LPS-TLR4 interaction. And we also learn the story of their research spanning multiple years and multiple discoveries building upon each other.
Chapters 4-6 delve into the mechanisms of adaptive immunity and their main cell types: B- and T-lymphocytes. Have you ever wondered how the immune system is able to "remember" earlier infections? You'll find here both an overview of "immune memory" and a detailed description how B and T cell proliferate and specialize.
Chapter 7 shows how these immune reactions are sometimes provoked by harmless substances - that's what we call allergy. Or even by human cells - that's what we call autoimmune diseases.
The next chapters put the immune system into a bigger context. They discuss the variability of immunity across different individuals and the many reasons behind it. Genes, environment, past infections, life style. A particularly fascinating part of "the human ecosystem" is the microbiota. Its importance has been recognized only in the last two decades. Chapter 8 introduces really well this emerging field of study.
Chapter 11 is dedicated to an immunology topic that affects all of us: vaccines. Building upon the knowledge from previous chapters, it explains how vaccines work.
Throughout the book, we learn a lot both about the exciting developments and the open questions in the field of immunology. Chapter 12 gives a summary of some trends of the last decades and an outlook for the next big puzzles to tackle.
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Situated at the intersection of natural science and philosophy, Our Genes: A Philosophical Perspective on Human Evolutionary Genomics (Cambridge University Press, 2023) explores historical practices, investigates current trends, and imagines future work in genetic research to answer persistent, political questions about human diversity. Readers are guided through fascinating thought experiments, complex measures and metrics, fundamental evolutionary patterns, and in-depth treatment of exciting case studies. The work culminates in a philosophical rationale, based on scientific evidence, for a moderate position about the explanatory power of genes that is often left unarticulated. Simply put, human evolutionary genomics - our genes - can tell us much about who we are as individuals and as collectives. However, while they convey scientific certainty in the popular imagination, genes cannot answer some of our most important questions. Alternating between an up-close and a zoomed-out focus on genes and genomes, individuals and collectives, species and populations, Our Genes argues that the answers we seek point to rich, necessary work ahead.
Rasmus Grønfeldt Winther is a philosopher of science, researcher, writer, educator, diver, and explorer. He is Professor of Humanities at University of California, Santa Cruz and Affiliate Professor of Transformative Science at the GLOBE Institute at University of Copenhagen.
Caleb Zakarin is editor at the New Books Network.
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Peoples & Things host, Lee Vinsel, talks with Guru Madhavan, Norman R. Augustine Senior Scholar and Senior Director of Programs at the National Academy of Engineering, about his recent book, Wicked Problems: How to Engineer a Better World (W. W. Norton & Company, 2024). In Wicked Problems, Madhavan draws on a rich body of literature from the humanities and social sciences to think through how engineers can do a better job working on problems that include complex social and technical realities. The pair also talk about how Madhavan came to the National Academy of Engineering after working as an engineer and entrepreneur and some of his future work, including ongoing writing on the importance of maintenance and “grind problems” in engineering.
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Claudia de Rham has been playing with gravity her entire life. As a diver, experimenting with her body's buoyancy in the Indian Ocean. As a pilot, soaring over Canadian waterfalls on dark mornings before beginning her daily scientific research. As an astronaut candidate, dreaming of the experience of flying free from Earth's pull. And as a physicist, discovering new sides to gravity's irresistible personality by exploring the limits of Einstein's general theory of relativity. 
In The Beauty of Falling: A Life in Pursuit of Gravity (Princeton UP, 2024), de Rham shares captivating stories about her quest to gain intimacy with gravity, to understand both its feeling and fundamental nature. Her life's pursuit led her from a twist of fate that snatched away her dream of becoming an astronaut to an exhilarating breakthrough at the very frontiers of gravitational physics.
While many of us presume to know gravity quite well, the brightest scientists in history have yet to fully answer the simple question: what exactly is gravity? De Rham reveals how great minds--from Newton and Einstein to Stephen Hawking, Andrea Ghez, and Roger Penrose--led her to the edge of knowledge about this fundamental force. She found hints of a hidden side to gravity at the particle level where Einstein's theory breaks down, leading her to develop a new theory of "massive gravity." De Rham shares how her life's path turned from a precipitous fall to an exquisite flight toward the discovery of something entirely new about our surprising, gravity-driven universe.
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