Urticarial Vasculitis, Part 2: Walking the Balance Beam of Allergy and Rheumatology Healio Rheuminations

This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.
·       Intro 0:11
·       In this episode 0:22
·       Review of episode 83 1:23
·       Listen to previous episode, The Complement System for Dunces 4:09
·       Anti-C1q antibodies 6:26
·       Lupus, anti-C1q and lupus nephritis 9:33
·       What happens when you inject anti-C1q in a mouse? 12:56
·       The allergy component: anti-C1q, urticaria and angioedema 17:36
·       Bradykinin-mediated angioedema and C1q deficiency 24:20
·       What is the kinin kallikrein system? 26:21
·       French researchers in 1909: human urine injected in dogs 27:30
·       How is this relevant to urticarial vasculitis? 31:08
·       SERPING1 gene mutation 31:23
·       Summary 32:06
·       COPD association with urticarial vasculitis 33:51
·       Coming up in episode 85 35:28
·       Thanks for listening 35:45
Disclosures: Brown reports no relevant financial disclosures.
We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum.
References:
Busse P, et al. J Allergy Clin Immunol Pract. 2022;doi:10.1016/j.jaip.2021.11.011.
Davis MDP, et al. J Allergy Clin Immunol Pract. 2018;doi:10.1016/j.jaip.2018.05.006.
Dorn JM, et al. Ann Allergy Asthma Immunol. 2023;doi:10.1016/j.anai.2023.06.014.
Marzano AV, et al. J Allergy Clin Immunol. 2022;doi:10.1016/j.jaci.2022.02.007.
Siegert CE, et al. Clin Immunol Immunopathol. 1993;doi:10.1006/clin.1993.1066.
Stojan G, et al. Lupus. 2016;doi:10.1177/0961203316645205.
Venzor J, et al. Clin Rev Allergy Immunol. 2002;doi:10.1385/CRIAI:23:2:201.
Wisnieski JJ, et al. Medicine. 1995;doi:10.1097/00005792-199501000-00003.