28 episodi

Cardiology podcast for internists, residents and medical students. We review common questions for cardiologists and recent research.

AP Cardiology Andrew Perry

    • Scienze

Cardiology podcast for internists, residents and medical students. We review common questions for cardiologists and recent research.

    HFpEF and Amyloid – Frederick Ruberg

    HFpEF and Amyloid – Frederick Ruberg

    I met with Dr. Frederick Ruberg from Boston University to discuss his talk from AHA 2019 titled “HFpEF: It’s a Diagnosis of Exclusion, So Exclude Other Causes!” We discuss what the diagnosis of HFpEF entails and then dive into cardiac amyloidosis and what populations should be screened for amyloid. Links to papers work via apcardiology.com



    Links:



    Unveiling transthyretin cardiac amyloidosis and its predictors among elderly patients with severe aortic stenosis undergoing transcatheter aortic valve replacement.



    Expert Consensus Recommendations for Multimodality Imaging in Cardiac Amyloidosis



    Identification of Transthyretin Cardiac Amyloidosis Using Serum Retinol-Binding Protein 4 and a Clinical Prediction Model

    • 26 min
    ACS Update – 2019 with James de Lemos

    ACS Update – 2019 with James de Lemos

    I caught up with Dr. James de Lemos from UT Southwestern at the 2019 American Heart Association meeting to discuss a number of updates in acute coronary syndromes. We cover a number of recent trials that are shaping how we think about ACS management from medications, stent deployment and the mechanism we might be overlooking.



    Links to articles:



    ISAR-REACT 5



    TWILIGHT



    POPular Genetics



    COMPASS

    • 11 min
    Decompensated heart failure with Dr. Kittleson

    Decompensated heart failure with Dr. Kittleson

    In this episode I visit with Dr. Michelle Kittleson (@MKIttlesonMD) of Cedars-Sinai to discuss evaluation and management of patients admitted with acute decompensated heart failure. We review the etiologies for decompensation, what to do with beta-blockers or RAS inhibitors and how to setup the patient for a successful discharge.



    Links to papers:



    Effects of Beta-blocker Withdrawal Meta-Analysis



    Early worsening renal function after initiation of ACE inhibitor, Testani Circulation Heart Failure 2011



    DOSE Trial



    Furosemide v Torsemide



    PARADIGM-HF



    DAPA-HF

    • 48 min
    ASDs and VSDs with Amber Khanna

    ASDs and VSDs with Amber Khanna

    In this episode I visit with Dr. Amber Khanna of the University of Colorado about some of the “simple” congenital heart defects. We discuss atrial septal defects (ASD) and ventricular septal defect (VSD). We review useful testing to diagnose and evaluate these defects and the indications for closure.



    Links:



    2018 ACC/AHA Guidelines for the Management of Adults with Congenital Heart Disease



    Adult Congenital Heart Association

    • 50 min
    Hypertension with Eugene Yang

    Hypertension with Eugene Yang

    In this episode I visit with Dr. Eugene Yang to discuss the update to hypertension guidelines published in 2017 by the ACC/AHA. I asked him what were the major changes and which patients should be treated to a target of 130/80 and practical aspects to management.



    Links:



    2017 ACC/AHA Hypertension Guidelines

    • 45 min
    Immune Checkpoint Inhibitors

    Immune Checkpoint Inhibitors

    Following up on our last discussion with Dr. Daniel Lenihan, we address the subject of immune checkpoint inhibitors and the associated cardio-toxicities. Immune checkpoint inhibitors “ease the brakes” of the immune system leading to dramatic improvements in some cancers, but rarely this can lead to profound cardiovascular compromise. Hyperlinks to references on apcardiology.com



    References:



    Cardiovascular toxicities associated with immune checkpoint inhibitors



    Fulminant myocarditis with combination immune checkpoint blockade



    Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

    • 42 min

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