AJT Highlights American Journal of Transplantation

In this specialty podcase, AJT Fellow and host David Cron is joined by Jesse Schold and Joel Adler to provide an overview policy evaluation in transplantation, including analytical approaches, pitfalls, and best practices.
References
Stewart et al. “Does anyone really know what (the kidney median waiting) time is?”  
Noreen et al. “Augmenting the United States transplant registry with external mortality data: A moving target ripe for further improvement”
Shifman et al. “Association of state Medicaid expansion policies with pediatric liver transplant outcomes”

Host Roz is joined by AJT Associate Editor Orla Morrissey, MD (Monash University) and AJT Editorial Fellow Elena-Bianca Barbir, MD (Mayo Clinic-Rochester).
[3:16] The respiratory syncytial virus vaccines are here: Implications for solid organ transplantation
[19:14] Association between cytomegalovirus viremia and long-term outcomes in lung transplant recipients
[35:40] Genetic versus self-reported African ancestry of the recipient and neighborhood predictors of kidney transplantation outcomes in 2 multiethnic urban cohorts
[EDITORIAL] Untangling genetic and environmental risks in kidney transplant outcomes: The interplay of self-identified race, genetic ancestry, monogenic risk alleles, and socioeconomic factors
[45:15] Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity
[53:44] Outcomes in solid organ transplant recipients with a pretransplant diagnosis of melanoma

In this AJT specialty podcast, Luise Holzhauser, hosts Shelley Hall and Marie Budev to discuss the impact of the 2018 change in heart allocation and what the heart community can learn from experiences with continuous distribution of lung.

Host Roz is joined by AJT Executive Guest Editor Nadim Mahmud, MD, MPH (University of Pennsylvania) and AJT Editorial Fellow Tina Marinelli, MBBS, MPH&TM,  FRACP (Royal Prince Alfred Hospital).

 
[03:10] Semidirected Living Donors in Israel: Sociodemographic Profile, Religiosity, and Social Tolerance
 
[11:54] TCRseq Reveals Selected Donor-reactive CD8+ T cell Clones Resist Anti-Thymocyte Globulin Depletion after Kidney Transplantation
 
[18:47] Natural killer cell functional genetics and donor-specific antibody-triggered microvascular inflammation
 
[26:36] Surgical site infections after kidney transplantation are independently associated with graft loss
 
[38:26] Introduction to Virtual Special Issue, Insights into ACLF: From Pathogenesis to Interventions
 
[39:21] Immunopathogenesis of acute on chronic liver failure
 
[43:43] Geographic disparities in access to liver transplant for advanced cirrhosis: Time to ring the alarm!

Host Roz is joined by AJT Editor-in-Chief Emeritus Allan Kirk, MD, PhD, (Duke University) and AJT Editorial Fellow Laura Binari, MD (Vanderbilt University).
[2:34] Abdominal computed tomography measurements of body composition and waitlist mortality in kidney transplant candidates
[14:09] A2/A2B to B deceased donor kidney transplantation in the Kidney Allocation System era
[24:01] Xenotransplantation Papers
[25:07] Xenotransplantation experiments in brain-dead human subjects–A critical appraisal
[28:11] The decedent model: A new paradigm for de-risking high stakes clinical trials like xenotransplantation
[32:45] Exploring the single-cell immune landscape of kidney allograft inflammation using imaging mass cytometry

Host Roz is joined by AJT Editorial Board Member Alexandre Loupy, MD, PhD (Necker Hospital) and AJT Editorial Fellow Thiago J Borges, PhD (Massachusetts General Hospital).
[2:39] Transplanting old organs promotes senescence in young recipients
[11:33] The Banff 2022 Kidney Meeting Report: Reappraisal of microvascular inflammation and the role of biopsy-based transcript diagnostics
[15:45] The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts
(Editorial) [18:12] The Banff process—Reloaded: A joint initiative from the Banff Foundation for Allograft Pathology and the American Journal of Transplantation
[20:25] Antiobesity pharmacotherapy to facilitate living kidney donation
[27:04] Ambient air pollution is associated with graft failure/death in pediatric liver transplant recipients