80,000 Hours Podcast Rob, Luisa, Keiran, and the 80,000 Hours team

"Suppose we make these grants, we do some of those experiments I talk about. We discover, for example — I’m just making this up — but we give people superforecasting tests when they’re doing peer review, and we find that you can identify people who are super good at picking science. And then we have this much better targeted science, and we’re making progress at a 10% faster rate than we normally would have. Over time, that aggregates up, and maybe after 10 years, we’re a year ahead of where we would have been if we hadn’t done this kind of stuff.
"Now, suppose in 10 years we’re going to discover a cheap new genetic engineering technology that anyone can use in the world if they order the right parts off of Amazon. That could be great, but could also allow bad actors to genetically engineer pandemics and basically try to do terrible things with this technology. And if we’ve brought that forward, and that happens at year nine instead of year 10 because of some of these interventions we did, now we start to think that if that’s really bad, if these people using this technology causes huge problems for humanity, it begins to sort of wash out the benefits of getting the science a little bit faster." —Matt Clancy
In today’s episode, host Luisa Rodriguez speaks to Matt Clancy — who oversees Open Philanthropy’s Innovation Policy programme — about his recent work modelling the risks and benefits of the increasing speed of scientific progress.
Links to learn more, highlights, and full transcript.
They cover:
Whether scientific progress is actually net positive for humanity.Scenarios where accelerating science could lead to existential risks, such as advanced biotechnology being used by bad actors.Why Matt thinks metascience research and targeted funding could improve the scientific process and better incentivise outcomes that are good for humanity.Whether Matt trusts domain experts or superforecasters more when estimating how the future will turn out.Why Matt is sceptical that AGI could really cause explosive economic growth.And much more.Chapters:
Is scientific progress net positive for humanity? (00:03:00)The time of biological perils (00:17:50)Modelling the benefits of science (00:25:48)Income and health gains from scientific progress (00:32:49)Discount rates (00:42:14)How big are the returns to science? (00:51:08)Forecasting global catastrophic biological risks from scientific progress (01:05:20)What’s the value of scientific progress, given the risks? (01:15:09)Factoring in extinction risk (01:21:56)How science could reduce extinction risk (01:30:18)Are we already too late to delay the time of perils? (01:42:38)Domain experts vs superforecasters (01:46:03)What Open Philanthropy’s Innovation Policy programme settled on (01:53:47)Explosive economic growth (02:06:28)Matt’s favourite thought experiment (02:34:57)Producer and editor: Keiran HarrisAudio engineering lead: Ben CordellTechnical editing: Simon Monsour, Milo McGuire, and Dominic ArmstrongAdditional content editing: Katy Moore and Luisa RodriguezTranscriptions: Katy Moore

"Earth economists, when they measure how bad the potential for exploitation is, they look at things like, how is labour mobility? How much possibility do labourers have otherwise to go somewhere else? Well, if you are on the one company town on Mars, your labour mobility is zero, which has never existed on Earth. Even in your stereotypical West Virginian company town run by immigrant labour, there’s still, by definition, a train out. On Mars, you might not even be in the launch window. And even if there are five other company towns or five other settlements, they’re not necessarily rated to take more humans. They have their own oxygen budget, right?
"And so economists use numbers like these, like labour mobility, as a way to put an equation and estimate the ability of a company to set noncompetitive wages or to set noncompetitive work conditions. And essentially, on Mars you’re setting it to infinity." — Zach Weinersmith
In today’s episode, host Luisa Rodriguez speaks to Zach Weinersmith — the cartoonist behind Saturday Morning Breakfast Cereal — about the latest book he wrote with his wife Kelly: A City on Mars: Can We Settle Space, Should We Settle Space, and Have We Really Thought This Through?
Links to learn more, highlights, and full transcript.
They cover:
Why space travel is suddenly getting a lot cheaper and re-igniting enthusiasm around space settlement.What Zach thinks are the best and worst arguments for settling space.Zach’s journey from optimistic about space settlement to a self-proclaimed “space bastard” (pessimist).How little we know about how microgravity and radiation affects even adults, much less the children potentially born in a space settlement.A rundown of where we could settle in the solar system, and the major drawbacks of even the most promising candidates.Why digging bunkers or underwater cities on Earth would beat fleeing to Mars in a catastrophe.How new space settlements could look a lot like old company towns — and whether or not that’s a bad thing.The current state of space law and how it might set us up for international conflict.How space cannibalism legal loopholes might work on the International Space Station.And much more.Chapters:
Space optimism and space bastards (00:03:04)Bad arguments for why we should settle space (00:14:01)Superficially plausible arguments for why we should settle space (00:28:54)Is settling space even biologically feasible? (00:32:43)Sex, pregnancy, and child development in space (00:41:41)Where’s the best space place to settle? (00:55:02)Creating self-sustaining habitats (01:15:32)What about AI advances? (01:26:23)A roadmap for settling space (01:33:45)Space law (01:37:22)Space signalling and propaganda (01:51:28) Space war (02:00:40)Mining asteroids (02:06:29)Company towns and communes in space (02:10:55)Sending digital minds into space (02:26:37)The most promising space governance models (02:29:07)The tragedy of the commons (02:35:02)The tampon bandolier and other bodily functions in space (02:40:14)Is space cannibalism legal? (02:47:09)The pregnadrome and other bizarre proposals (02:50:02)Space sexism (02:58:38)What excites Zach about the future (03:02:57)Producer and editor: Keiran HarrisAudio engineering lead: Ben CordellTechnical editing: Simon Monsour, Milo McGuire, and Dominic ArmstrongAdditional content editing: Katy Moore and Luisa RodriguezTranscriptions: Katy Moore

"I work in a place called Uttar Pradesh, which is a state in India with 240 million people. One in every 33 people in the whole world lives in Uttar Pradesh. It would be the fifth largest country if it were its own country. And if it were its own country, you’d probably know about its human development challenges, because it would have the highest neonatal mortality rate of any country except for South Sudan and Pakistan. Forty percent of children there are stunted. Only two-thirds of women are literate. So Uttar Pradesh is a place where there are lots of health challenges.
"And then even within that, we’re working in a district called Bahraich, where about 4 million people live. So even that district of Uttar Pradesh is the size of a country, and if it were its own country, it would have a higher neonatal mortality rate than any other country. In other words, babies born in Bahraich district are more likely to die in their first month of life than babies born in any country around the world." — Dean Spears
In today’s episode, host Luisa Rodriguez speaks to Dean Spears — associate professor of economics at the University of Texas at Austin and founding director of r.i.c.e. — about his experience implementing a surprisingly low-tech but highly cost-effective kangaroo mother care programme in Uttar Pradesh, India to save the lives of vulnerable newborn infants.
Links to learn more, highlights, and full transcript.
They cover:
The shockingly high neonatal mortality rates in Uttar Pradesh, India, and how social inequality and gender dynamics contribute to poor health outcomes for both mothers and babies.The remarkable benefits for vulnerable newborns that come from skin-to-skin contact and breastfeeding support.The challenges and opportunities that come with working with a government hospital to implement new, evidence-based programmes.How the currently small programme might be scaled up to save more newborns’ lives in other regions of Uttar Pradesh and beyond.How targeted health interventions stack up against direct cash transfers.Plus, a sneak peak into Dean’s new book, which explores the looming global population peak that’s expected around 2080, and the consequences of global depopulation.And much more.Chapters:
Why is low birthweight a major problem in Uttar Pradesh? (00:02:45)Neonatal mortality and maternal health in Uttar Pradesh (00:06:10)Kangaroo mother care (00:12:08)What would happen without this intervention? (00:16:07)Evidence of KMC’s effectiveness (00:18:15)Longer-term outcomes (00:32:14)GiveWell’s support and implementation challenges (00:41:13)How can KMC be so cost effective? (00:52:38)Programme evaluation (00:57:21)Is KMC is better than direct cash transfers? (00:59:12)Expanding the programme and what skills are needed (01:01:29)Fertility and population decline (01:07:28)What advice Dean would give his younger self (01:16:09)Producer and editor: Keiran HarrisAudio engineering lead: Ben CordellTechnical editing: Simon Monsour, Milo McGuire, and Dominic ArmstrongAdditional content editing: Katy Moore and Luisa RodriguezTranscriptions: Katy Moore

"The constraint right now on factory farming is how far can you push the biology of these animals? But AI could remove that constraint. It could say, 'Actually, we can push them further in these ways and these ways, and they still stay alive. And we’ve modelled out every possibility and we’ve found that it works.' I think another possibility, which I don’t understand as well, is that AI could lock in current moral values. And I think in particular there’s a risk that if AI is learning from what we do as humans today, the lesson it’s going to learn is that it’s OK to tolerate mass cruelty, so long as it occurs behind closed doors. I think there’s a risk that if it learns that, then it perpetuates that value, and perhaps slows human moral progress on this issue." —Lewis Bollard
In today’s episode, host Luisa Rodriguez speaks to Lewis Bollard — director of the Farm Animal Welfare programme at Open Philanthropy — about the promising progress and future interventions to end the worst factory farming practices still around today.
Links to learn more, highlights, and full transcript.
They cover:
The staggering scale of animal suffering in factory farms, and how it will only get worse without intervention.Work to improve farmed animal welfare that Open Philanthropy is excited about funding.The amazing recent progress made in farm animal welfare — including regulatory attention in the EU and a big win at the US Supreme Court — and the work that still needs to be done.The occasional tension between ending factory farming and curbing climate changeHow AI could transform factory farming for better or worse — and Lewis’s fears that the technology will just help us maximise cruelty in the name of profit.How Lewis has updated his opinions or grantmaking as a result of new research on the “moral weights” of different species.Lewis’s personal journey working on farm animal welfare, and how he copes with the emotional toll of confronting the scale of animal suffering.How listeners can get involved in the growing movement to end factory farming — from career and volunteer opportunities to impactful donations.And much more.Chapters:
Common objections to ending factory farming (00:13:21)Potential solutions (00:30:55)Cage-free reforms (00:34:25)Broiler chicken welfare (00:46:48)Do companies follow through on these commitments? (01:00:21)Fish welfare (01:05:02)Alternatives to animal proteins (01:16:36)Farm animal welfare in Asia (01:26:00)Farm animal welfare in Europe (01:30:45)Animal welfare science (01:42:09)Approaches Lewis is less excited about (01:52:10)Will we end factory farming in our lifetimes? (01:56:36)Effect of AI (01:57:59)Recent big wins for farm animals (02:07:38)How animal advocacy has changed since Lewis first got involved (02:15:57)Response to the Moral Weight Project (02:19:52)How to help (02:28:14)Producer and editor: Keiran HarrisAudio engineering lead: Ben CordellTechnical editing: Simon Monsour, Milo McGuire, and Dominic ArmstrongAdditional content editing: Katy Moore and Luisa RodriguezTranscriptions: Katy Moore

Many of you will have heard of Zvi Mowshowitz as a superhuman information-absorbing-and-processing machine — which he definitely is. As the author of the Substack Don’t Worry About the Vase, Zvi has spent as much time as literally anyone in the world over the last two years tracking in detail how the explosion of AI has been playing out — and he has strong opinions about almost every aspect of it.
Links to learn more, summary, and full transcript.
In today’s episode, host Rob Wiblin asks Zvi for his takes on:
US-China negotiationsWhether AI progress has stalledThe biggest wins and losses for alignment in 2023EU and White House AI regulationsWhich major AI lab has the best safety strategyThe pros and cons of the Pause AI movementRecent breakthroughs in capabilitiesIn what situations it’s morally acceptable to work at AI labsWhether you agree or disagree with his views, Zvi is super informed and brimming with concrete details.
Zvi and Rob also talk about:
The risk of AI labs fooling themselves into believing their alignment plans are working when they may not be.The “sleeper agent” issue uncovered in a recent Anthropic paper, and how it shows us how hard alignment actually is.Why Zvi disagrees with 80,000 Hours’ advice about gaining career capital to have a positive impact.Zvi’s project to identify the most strikingly horrible and neglected policy failures in the US, and how Zvi founded a new think tank (Balsa Research) to identify innovative solutions to overthrow the horrible status quo in areas like domestic shipping, environmental reviews, and housing supply.Why Zvi thinks that improving people’s prosperity and housing can make them care more about existential risks like AI.An idea from the online rationality community that Zvi thinks is really underrated and more people should have heard of: simulacra levels.And plenty more.Chapters:
Zvi’s AI-related worldview (00:03:41)Sleeper agents (00:05:55)Safety plans of the three major labs (00:21:47)Misalignment vs misuse vs structural issues (00:50:00)Should concerned people work at AI labs? (00:55:45)Pause AI campaign (01:30:16)Has progress on useful AI products stalled? (01:38:03)White House executive order and US politics (01:42:09)Reasons for AI policy optimism (01:56:38)Zvi’s day-to-day (02:09:47)Big wins and losses on safety and alignment in 2023 (02:12:29)Other unappreciated technical breakthroughs (02:17:54)Concrete things we can do to mitigate risks (02:31:19)Balsa Research and the Jones Act (02:34:40)The National Environmental Policy Act (02:50:36)Housing policy (02:59:59)Underrated rationalist worldviews (03:16:22)Producer and editor: Keiran HarrisAudio Engineering Lead: Ben CordellTechnical editing: Simon Monsour, Milo McGuire, and Dominic ArmstrongTranscriptions and additional content editing: Katy Moore

Today’s release is a reading of our career review of AI governance and policy, written and narrated by Cody Fenwick.
Advanced AI systems could have massive impacts on humanity and potentially pose global catastrophic risks, and there are opportunities in the broad field of AI governance to positively shape how society responds to and prepares for the challenges posed by the technology.
Given the high stakes, pursuing this career path could be many people’s highest-impact option. But they should be very careful not to accidentally exacerbate the threats rather than mitigate them.
If you want to check out the links, footnotes and figures in today’s article, you can find those here.
Editing and audio proofing: Ben Cordell and Simon MonsourNarration: Cody Fenwick