에피소드 102개

This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to replace needing to read scientific papers on new research in an easy to digest way. Then people can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space

Neural Implant podcast - the people behind Brain-Machine Interface revolutions Ladan Jiracek

    • 의학

This podcast's purpose is to bring together the field of neuroprosthetics / brain machine interfaces / brain implants in an understandable conversation about the current topics and breakthroughs. We hope to replace needing to read scientific papers on new research in an easy to digest way. Then people can share thoughts or ideas to facilitate 'idea sex' to make the field of brain implants a smaller and more personal space

    Announcement: U.S. Small Business Administration (SBA) Loan Offer

    Announcement: U.S. Small Business Administration (SBA) Loan Offer

    We know you are facing challenging times in this current health crisis. The U.S. Small Business Administration is committed to help bring relief to small businesses and nonprofit organizations suffering because of the Coronavirus (COVID-19) pandemic. 
    On March 27, 2020, President Trump signed into law the CARES Act, which provided additional assistance for small business owners and non-profits, including the opportunity to get up to a $10,000 Advance on an Economic Injury Disaster Loan (EIDL). This Advance may be available even if your EIDL application was declined or is still pending, and will be forgiven.
    If you wish to apply for the Advance on your EIDL, please visit www.SBA.gov/Disaster as soon as possible to fill out a new, streamlined application. In order to qualify for the Advance, you need to submit this new application even if you previously submitted an EIDL application. Applying for the Advance will not impact the status or slow your existing application.
    Also, we encourage you to subscribe to our email updates via www.SBA.gov/Updates and follow us on Twitter at @SBAgov for the latest news on available SBA resources and services. If you need additional assistance, you can find your local SBA office and resource partners at www.SBA.gov/LocalAssistance. If you have questions, you may also call 1-800-659-2955.

    • 2분
    Daniel Powell Discusses an Auricular Nerve Stimulation Device to Treat Opioid Withdrawal

    Daniel Powell Discusses an Auricular Nerve Stimulation Device to Treat Opioid Withdrawal

    Daniel Powell is the CEO of Spark Biomedical, a medical device company based in Texas whose mission is to develop effective, wearable neurostimulation devices. In this episode, he discusses an auricular nerve stimulator to aid in the relief of opioid withdrawal both in adults and newborn infants.
    Top three takeaways:
    This auricular, transcutaneous nerve stimulator device works to alleviate opioid withdrawal by stimulating the necessary nerves to kickstart endogenous endorphin release in the brain. A major part of opioid addiction is avoiding withdrawals; opioids chemically replace endorphins and bind to opioid receptors, and the brain no longer produces endogenous endorphins, so that when the user no longer takes the drugs, they no longer have the necessary chemicals to deal with anxiety and pain. This is what makes opioid withdrawals unique and is why opioid addicts try so hard to avoid them. When starting a project, it is highly beneficial to have a diverse team of people with different skill sets that can contribute to every aspect of the project. [0:00] Powell explains his job  – Spark Biomedical is currently developing an auricular, transcutaneous nerve stimulator designed to stimulate specific cranial nerve branches and is designed to relieve opioid withdrawal
    [3:45] There is some evidence to support the efficacy of acupuncture-based stimulation for treating opioid withdrawal in adults, which is the basis for the creation of the non-invasive auricular nerve stimulator
    [7:15] The ear pieces are easy to apply and disposable – since there are no needles, it is easy to replace the ear pieces as needed
    [9:15] When observing withdrawal symptoms in adults using this device, one can observe that the common symptoms – shaking, sweating, etc. – approach a normal level over a 60-minute window
    [10:45] So far, there have not been issues with the FDA, as Spark Biomedical has completed their pre-submission process, where they write down the questions to be answered by the FDA
    [13:30] This is Spark Biomedical’s first main project; the company was formed specifically for this project at the end of 2018, and there was a good network of people to call on for both scientific and financial applications
    [16:45] When someone is addicted to opioids, they are not simply chasing euphoria, but are also trying to run away from withdrawals
    [20:45] During acute withdrawal, the stimulator helps to jump-start the brain to produce the endogenous endorphins necessary to occupy opioid receptors, which helps to alleviate withdrawal
    [23:45] A good dose of endogenous endorphins can alleviate withdrawal symptoms for a long time; one subject who used the stimulator device for an hour felt no withdrawal symptoms for six hours after removing the device
    [25:15] The project is currently in clinical trials for adults, and Spark Biomedical is currently partnered with MUSC to run the trials for infants; the hope is that the product is on market for adults in the second half of 2020
    [28:15] A good piece of entrepreneurial advice is to have a diverse team with different educational backgrounds and skill sets to be able to contribute to every aspect of the project
    [31:30] A challenge when building the company is that it was built remotely, and does not convene in a single office
    [34:00] The company was built on people who were tired of corporate life, and pays based on results rather than hours

    • 36분
    COVID-19 Update and How Grant Agencies are Helping Researchers

    COVID-19 Update and How Grant Agencies are Helping Researchers

    This outbreak of COVID-19 is a very difficult time for scientific research. A lot of experiments are being interrupted and put on pause, and conference travels are essentially not possible. In this episode, Ladan discusses what steps are being taken by government grant-funding agencies to assist researchers during this time.
    Top three takeaways:
    Grant-funding agencies such as the NIH and NSF are extending deadlines for grants and experiments, and late applications are being accepted without the need for pre-approval. NIH grant money can be used to cover fees incurred from interrupted travel, as well as changing any protocols as necessary. The safety and health of researchers and research participants alike is the number one priority during this time. [0:00] Ladan introduces the episode
    [1:30] The NIH and the NSF will extend the deadline for many grants and experiments during this time
    [3:45] Dr. Mike Lauer from the NIH explains the implications of this pandemic on scientific research and the way the NIH will be cooperating with researchers during this time
    [5:30] The NIH has put out a guide notice stating that late applications will not need pre-approval
    [8:00] Hotel and airline refund fees, as well as any other fees incurred due to interrupted travel, can be charged to NIH grants
    [9:45] There will be opportunities to apply for administrative supplements to cover costs incurred due to changing protocols and venues
    [11:00] This is a very difficult time, but also a time of compassion
    Info on how NIH is responding to the outbreak: https://www.nih.gov/health-information/coronavirus
    Message from Dr. Mike Lauer: https://www.youtube.com/watch?v=jLmBi5wvifk&feature=youtu.be
    Info on how NSF is responding to the outbreak: https://www.nsf.gov/news/special_reports/coronavirus/
    Producer’s log: I wrote these notes while in quarantine. Ladan locked me up in a tiny room and I don’t know why. He said it was for my own good, and that he’ll let me out "once the storm passes". I haven’t been outside in over 2 weeks. I miss the world. I miss the laughter. I miss the sunshine. Someone please help me.
    Producer's log update: OK I'm just kidding, I'm not really locked in a little room. But I do miss socializing with people, I'm starting to get very lonely.

    • 11분
    Jeremy Magland and James Jun Discuss the Flatiron Institute and Spike Sorting Algorithms

    Jeremy Magland and James Jun Discuss the Flatiron Institute and Spike Sorting Algorithms

    Jeremy Magland and James Jun are researchers at the Flatiron Institute whose work involves spike sorting for analysis of large recorded neuronal data sets. In this episode, at the SfN 2019 Conference, they discuss the Flatiron Institute, spike sorting and the various algorithms involved in it, as well as an open-source algorithm the Flatiron Institute has developed for spike sorting and how it works.
    Top three takeaways:
    The Flatiron Institute, a division of the Simons Foundation, uses modern computing tools to advance scientific understanding, and they provide open-source code to aid labs in data analysis. Spike sorting algorithms take recorded extracellular data and use statistical methods to group it into clusters, from which it determines the number of neurons that are firing. The difference in clustering and sorting depends on the specific type of analysis the algorithm runs. MountainSort is an open-source spike sorting software that is distinct in that it doesn’t require as many input parameters as other algorithms do. [0:40] Ladan introduces the episode and the guests, James Jun and Jeremy Magland, at SfN 2019; Jun gives his background and what he is studying
    [3:40] Jun explains how spike sorting uses extracellular recordings to receive signals from different neurons at once
    [4:55] Magland gives his background and what he is studying
    [8:05] There’s a rainbow
    [9:10] Magland and Jun explain some advantages/benefits of the Flatiron Institute, a research division of the Simons Foundation; the institute creates open-source software to help labs with spike sorting
    [11:40] Jun discusses the Simons Foundation, how they started, how they created the Flatiron Institute, and the types of projects they fund
    [14:10] MountainSort is the open-source spike sorting algorithm developed by Flatiron which clusters spikes by using a statistical method to detect differences in spike densities and separate the neurons accordingly. This doesn’t require adjustable parameters as input, unlike other software.
    [16:40] Jun discusses some differences in certain spike sorting algorithms and the type of analysis they use to sort spikes into different clusters and differentiate the neurons
    [19:55] Magland and Jun are looking forward to enhanced hardware and computing capabilities that improve the speed and accuracy of spike sorting

    • 20분
    Pablo Celnik Discusses a Neurorehabilitation Treatment for a Patient with Cervical Spinal Cord Injury

    Pablo Celnik Discusses a Neurorehabilitation Treatment for a Patient with Cervical Spinal Cord Injury

    Dr. Pablo Celnik is a professor of physical medicine and rehabilitation at Johns Hopkins University School of Medicine. Buzz is a spinal cord injury patient who has recently received implants to help him regain sensory and motor control of his body. In this episode, they discuss the project directed by Dr. Celnik that involves the implantation of a bilateral set of implants that has been effective in helping Buzz regain sensory and motor control.
    Top three takeaways:
    Buzz’s implants are unique due to the number of implants, and due to the fact that they are bilaterally implanted. The future of this project depends on factors such as funding and reapproval, and will likely involve observing how the addition of sensory information will help improve motor performance. It is important for spinal cord injury patients to understand that despite their injury, they can live a productive and happy life. [0:00] Ladan introduces the episode and the guests, Dr. Pablo Celnik and Buzz, a spinal cord injury patient, at SfN 2019; Buzz gives a background of his injury and condition
    [3:30] Dr. Celnik gives a background of his research, his department, and the project he is currently working on in neurorehabilitation
    [6:30] Buzz is special in that his implants are bilateral and more numerous; he has arrays in the dominant and non-dominant side, in both motor and somatosensory cortices
    [8:45] Buzz discusses his experience with learning to control his body using his implants
    [12:45] Dr. Celnik discusses his experience training Buzz with the new implants; they have started with one arm and have progressed to doing more complicated movements with both arms
    [16:15] Like any other research project, this project depends on every component’s support, including funding and yearly reapproval. The future for this project includes evaluating how the addition of sensory information helps with motor performance.
    [18:50] Buzz has also been involved in patient advocacy, where he has mentored and guided other spinal cord injury patients in a peer mentoring program
    [22:00] Dr. Celnik mentions the significance of this type of work to help spinal cord injury patients restore their quality of life
    [25:00] Patients like Buzz illustrate how the field of neuroscience can be translated to a practical, significant application

    • 27분
    February Neurotech News

    February Neurotech News

    Jennifer French and James Cavuoto are editors and publishers for Neurotech Reports, a news source whose mission is to provide up-to-date information about the field of neurotechnology that impacts research and venture capital. In this episode, they discuss some updates and recent events happening within the last month in the industry of neurotechnology.
    Top three takeaways:
    The 2020 North American Neuromodulation Society Annual Conference was a very informative and successful conference, and the Emerging Technologies Forum hosted by Neurotech News had great attendance and presentations Companies such as Medtronic are starting to capitalize on the use of glial cells in modulating pain networks Neurotech Reports will be hosting the Bioelectronic Medicine Forum which focuses on both the research and financial realms of bioelectronic medicine and neurotechnology  
    [0:00] Ladan introduces the episode and the two guests, Jennifer French and James Cavuoto, who start by discussing the North American Neuromodulation Society Annual Conference in Las Vegas, NV
    [3:40] French and Cavuoto discuss how large the event was and that it will likely take place again given the excellent turnout
    [4:45] The role of glial cells in pain networks was a very significant discussion according to Cavuoto; Medtronic is capitalizing on this with a startup called Stimgenics that they have recently acquired
    [6:45] A recent publication of Neurotech Business Report has discussed some failures of certain neurotech companies
    [8:20] The 2020 Bioelectronic Medicine Forum hosted by Neurotech Reports will take place in New York City on April 7, 2020, and it hones in on the bioelectronic medicine aspect of neurotechnology
    [10:40] Neurotech Reports has released an updated version of two whitepapers, one of which describes funding opportunities for startups, and one discusses venture capital funding

    • 11분

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