SciPod SciPod

Tuberculosis – or TB – is a global health threat, with 10 million new cases annually. Diagnosing TB can be a challenge, as there is a lack of rapid, point-of-care diagnostic tests. It can also be difficult to distinguish between TB and other inflammatory diseases, such as Sarcoidosis. One option may be to identify antibodies in patient samples that can reveal the presence of TB. However, current antibody tests for TB lack accuracy. Professor Lobelia Samavati and colleagues at the Wanye State University School of Medicine in Michigan are tackling this challenge to cast light on the immune signature of these diseases. Their aim is to develop new diagnostic techniques for TB and Sarcoidosis.

Many diseases become more likely to emerge as we age, with metabolic disorders such as diabetes, and neurodegenerative conditions, such as Alzheimer’s disease, representing two frequent manifestations of poor health in old age. While many age-related diseases present very differently, many share common underlying mechanisms. These include inflammation, a build-up of reactive oxygen molecules that can damage cellular components, and a lack of sensitivity to insulin. Treatments that can effectively target these mechanisms could have transformational effects on the age-related diseases that are fueled by them, including potentially preventing such diseases from developing in the first place. Prof. Christian Bréchot and colleagues at The Healthy Aging Company have developed a drug candidate: ALF5755, the pharmacological name of a protein called Hepatocarcinoma-Intestine-Pancreas, or HIP for short, also named Reg3A, that has shown exciting evidence of effectiveness on the cognitive disorders which occur during Alzheimer’s disease and the peripheral nerve damage that often occurs in diabetes, which is called diabetic neuropathy.

With a history as rich as its flavour, chocolate in its various forms has been loved by people for over 5000 years. Currently, however, chocolate is facing a serious threat. The improper disposal of cocoa waste products is spreading devastating diseases through cocoa crops across the world. To address this serious problem, Dr Piergiorgio Gentile from Newcastle University and Dr Joel Girón-Hernández from Northumbria University with their collaborators have been exploring new uses for cocoa waste products, to increase sustainability and prevent the spread of crop diseases.

Brazil, Russia, India and China, often known as the BRICs, have seen explosive growth in the past two decades and have asserted themselves as drivers of globalisation. Many scholars have researched the effects of this growth and development, and how these factors have affected domestic labour conditions. But are they asking the right questions? For instance, if developing countries invest in developed economies, will this lead to improved working conditions in the investing developing nation? Dr Patrick Wagner of the University of Konstanz, Germany, and Professor Damian Raess of the Catholic University of Lille, France, have conducted a study investigating whether Brazilian direct investment in Europe leads to improved working conditions back in Brazil.

Our world is facing new and frightening challenges, and political polarization has never been greater. Many see reasoned, respectful discourse as our only path to survival and progress, but attaining the skills and values it requires is not straightforward. Professor Deanna Kuhn of Columbia University has developed a discourse-based curriculum to help the next generation develop the values and the social and critical thinking skills they will need if they are to use tools of discourse to address the complex problems and challenges that await them.

In 18th century Britain, the old tradition of deep bowing and curtseying as a form of greeting slowly evolved into a brief touch of the cap or head (for men), or quick bob of the body (for women). Simultaneously, a new form of urban greeting was emerging: the handshake. How and why did the handshake gain such popularity, becoming our most standard greeting today? This phenomenon is explored in a new essay published in the journal Urban History and authored by Professor Penelope Corfield of London University.