Belle Talks About‪:‬ Belle Eden

In this episode I go over a few activities that can affect our gene expression, ergo why I even mentioned Biohacking. I am focusing mostly on meditation, and I will touch on a few interesting things about fasting. I am interested in anything that can improve my health or maintain a healthy body. Good health is the most important thing we take for granted; myself included. I have replaced a night's worth of sleep with meditation before, and in this episode I go into why I think that is. I am entering the realm at the edge of science; I am talking about things in this episode that we don't fully understand. We understand fasting more than we do sleep; and we all sleep more than we fast. Enjoy the episode. 



Resources: 

“Effects of sleep and wake on astrocytes: clues from molecular and ultrastructural studies”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4548305/

“What happens during sleep?”

https://www.nichd.nih.gov/health/topics/sleep/conditioninfo/what-happens

"Stages of Sleep"

https://www.sleepfoundation.org/stages-of-sleep






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Hello World, this by far is one of the most depressing topics I am interested in. I cover the severity of microplastics in our environment, how they affect us, and what we can do to solve this problem. I see the solution in Biology; life has already found a way, we just need to utilize it. There are microbes that have been found that can metabolize some plastics, and I lay out my ideas to how we could implement a solution. I even cover what I think would be some unintended consequences to the solution. Enjoy, if you can! 

Resources: 

"What are Microplastics?" https://oceanservice.noaa.gov/facts/microplastics.html

"Plastic: It's not all the same." https://plasticoceans.org/7-types-of-plastic/

"Endocrine Disruptors" https://www.niehs.nih.gov/health/topics/agents/endocrine/index.cfm

"Adipogenic Activity of Chemicals used in Plastic Consumer Products" https://pubs.acs.org/doi/10.1021/acs.est.1c06316

"Scientists accidentally create mutant enzyme that eats plastic bottles" https://www.theguardian.com/environment/2018/apr/16/scientists-accidentally-create-mutant-enzyme-that-eats-plastic-bottles

"Biodegradation of polyester polyurethane by Aspergillus tubingensis" https://www.sciencedirect.com/science/article/abs/pii/S0269749117300295




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In this episode I cover the topic of Stem Cells, ranging from what they are to how we optimize them to benefit the human species. 

There are many ways of manipulated Stem Cells, and I go over a few ways that researchers have identified. The use of microRNA and its implications for Stem Cells is covered as well. 

If we are able to manipulate Stem Cells however we please, it could be revolutionary for biotechnology and quality of life. The use of proper Stem Cell placement and manipulation could have incredible implications for Elon Musk's Neuralink, Space Exploration, and a world without Cancer. 

In my opinion, Stem Cells are the hope for the survival of the human species. 



Resources:

“Reprogrammed Pluripotent Stem Cells from Somatic Cells” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840974/

“microRNAs: important regulators of stem cells” https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0551-0#:~:text=miRNAs%20participate%20in%20the%20regulation,enhances%20reprogramming%20efficiency%20%5B25%5D.

“MicroRNA-Mediated Reprogramming of Somatic Cells into Induced Pluripotent Stem Cells” https://pubmed.ncbi.nlm.nih.gov/26621586/

“The Role of MicroRNAs in human cancer” https://www.nature.com/articles/sigtrans20154

“Virus-encoded microRNAs” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3052296/#:~:text=They%20are%20small%20non%2Dcoding,infectious%20cycle%20continues%20to%20grow.

“MicroRNAs are deeply linked to the emergence of the complex octopus brain” https://www.biorxiv.org/content/10.1101/2022.02.15.480520v1.full

“Current Developmentw in 3D Bioprinting for Tissue and Organ Regeneration- A Review”

https://www.frontiersin.org/articles/10.3389/fmech.2020.589171/full


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In this episode I talk about some novel compounds that have been discovered in Cannabis within the last 6 months. I always say, "There has to be something else we're missing besides Cannabinoids and Terpenes in what makes Cannabis beneficial." It turns out these compounds are similar to ones found in garlic and onions, and these compounds have some interesting biological mechanisms. 



Resources: 

“Identification of a New Family of Prenylated Volatile Sulfur Compounds in Cannabis Revealed by Comprehensive Two-Dimensional Gas Chromatography” https://doi.org/10.1021/acsomega.1c04196 https://pubs.acs.org/doi/10.1021/acsomega.1c04196

“A Review of Anticancer Effects in Garlic from Organosulfur Compounds” https://www.bhu.ac.in/research_pub/jsr/Volumes/JSR_65_02_2021/9.pdf

“Anticancer mechanisms of cannabinoids" Velasco, Sanchez, Guzman. Curr Oncol. 2016 Mar;23(S2):S23-S32

“Garlic-derived SEVs inhibit cancer cell proliferation and induce caspase mediated apoptosis”                                                  https://pubmed.ncbi.nlm.nih.gov/34285262/

“Bioactive Compounds and Biological functions of garlic” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6678835/

“Ceramide starves cells to death by downregulating nutrient transporter proteins” https://www.pnas.org/doi/10.1073/pnas.0802781105




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In this episode I talk about something that I have been passionate about for years: Viruses. 

Viruses are weird. Way weirder than you would think, and there are amazing applications that we can apply to viruses. 

We can potentially use viruses as the blueprint for biotechnology the way that we used the blueprint of birds to make planes and the blueprints of Bacteria to isolate and optimize CRISPR. 


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I talk about the relationship of many human species ranging from modern Homo sapiens, Neanderthals, Denisovans, and the Paracas People of Peru. The history of our species is incredible, and there is so much we still do not know. I talk about the facts we do know, the arrogance of archeology, and a sub-species of human that are taboo to talk about but existed. 

The Paracas People of Peru had elongated skulls, and their DNA has been tested. This is a mystery that should be discussed by more academics. Neanderthals and Denisovans also had larger skulls than modern humans, but the shape was different. The size or volume of the skull is not as important as the structures that can develop due to the shape of the skull.  

I try to be clear when I talk about undisputed scientific facts versus what my interpretation of things are. If I find that anything I said was wrong, I will correct myself in the future. I am just human, but what does that mean anymore? 

If you want to know more about the Paracus People, here is a link to Brien Foerster's website: https://hiddenincatours.com/. He is currently the leading expert on this topic. 

Here is the link to the website that shows a comparison of other hominid skulls: https://www.britannica.com/science/human-evolution/Increasing-brain-size. 


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