The Joe Cohen Show SelfDecode

In this episode, Joe dives deep into the effects of megadosing AKG (Alpha Ketoglutarate), a crucial supplement in metabolic pathways and its implications for longevity. Discover the risks and rewards as Joe recounts increasing his AKG intake to 15 times the standard dosage, leading to notable side effects such as enhanced anxiety and sleep issues. 

Joe meticulously explains the biochemical transformation of AKG into glutamate and reviews strategies to counteract these negative impacts, including the use of supplements like B6 and Niacin. 

He concludes by weighing the pros and cons of AKG.

Tune in to learn more about AKG supplementation, its potential benefits, and how to safely navigate its use for optimal health outcomes

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we delve into the pivotal role of the BHMT gene within the body's methylation process. 

We discuss how the BHMT enzyme is essential for catalyzing a vital reaction that transforms homocysteine into methionine. 

Additionally, we cover the importance of betaine in enhancing the methylation cycle. Betaine acts as a methyl donor, particularly in the reaction facilitated by the BHMT enzyme, making it crucial for reducing homocysteine levels and supporting cardiovascular and neurological health.

We also explore the complexity of methylation pathways and emphasize the need for a comprehensive evaluation of multiple genes to truly understand and optimize methylation.

Be sure to follow our podcast for more expert insights into how betaine, methylation, and genetics can be leveraged to optimize both body and brain health.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, Joe tackles a controversial new study that suggests even 25 milligrams of niacin could potentially increase the risk of heart disease. 

Delving deep into the world of niacin supplementation, Joe discusses how, despite these concerns, niacin offers numerous health benefits, including enhanced cognitive function, better mood, and increased energy levels.

Joe draws on personal experiences to compare the negatives against the significant positives of niacin, as he explores niacin's biochemical effects, particularly its interaction with proteins such as 2PY, 4PY, and VCAM1, all linked to cardiovascular health. 

Throughout the episode, Joe examines the importance of dosage, sharing insights into the varying effects of low versus high doses of niacin. 

Join Joe as he navigates the complexities of niacin use, advocating for a well-informed, nuanced approach to its benefits and risks.

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the complex interplay between the CNR1 gene, cannabinoid receptors, and cannabis. 

Discover the role of the endocannabinoid system in maintaining bodily balance, particularly in brain function, mood regulation, and inflammation response. 

We delve deep into how genetic variations in the CNR1 gene can influence the CB1 receptors, and the implications of CB1 receptor function in managing stress, anxiety, and cognitive processes such as memory and decision-making. 

Whether you're curious about the science behind getting high or looking for ways to optimize your cannabinoid system through diet and supplements like CBD oil, this episode has something for everyone. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/ 

In this episode, we explore the crucial role of serotonin in managing anxiety and enhancing mental wellbeing. 

Discover how serotonin not only influences mood but also plays a pivotal role in anxiety regulation and mental health. 

Learn about the HTR1A and HTR2A genes, which act like switches, controlling the serotonin levels in the brain. 

Understanding the SNPs in these genes can provide personal insights into your serotonin activity, offering potential strategies to alleviate anxiety, depression, and other mental health disorders. 

The episode further discusses how various serotonin receptors, affected by genetic differences, impact numerous physiological and psychological functions. 

Gain practical advice on how to balance your serotonin levels through diet, lifestyle choices, and supplements tailored to your genetic makeup, and see how this can significantly improve your mood and reduce anxiety. 

If you're interested in learning more about how your DNA and genetics affect your health:

- Check out SelfDecode: https://selfdecode.com/- Join Joe’s online community: https://thejoecohenshow.com/

In this episode, Joe takes questions from SelfDecode members, answering questions like:


What makes SelfDecode different from other DNA companies?


How does the recommendations engine work?


Can you find out if a certain supplement is right for you?



Plus, he shares some of his genetic predispositions and how they correlate with his lab levels!

- Check out SelfDecode: https://selfdecode.com/

- Join Joe’s online community: https://thejoecohenshow.com/