TED Talks Daily (HD video‪)‬ TED

Biomedical researcher Sonia Vallabh's life was turned upside down when she learned she had the genetic mutation for a rare and fatal illness, prion disease, that could strike at any time. Thirteen years later, her search for a cure has led to new insights about how to catch and prevent disease — and how to honor our grandest, most mysterious inheritance: our brains.

One in three workers globally will see their jobs disrupted by AI and tech advancements this decade — but there's a way to stay ahead of the curve. Skill-building strategist Sagar Goel shares practical examples from a partnership with the Singaporean government that helped thousands of workers transition into new careers, offering a lesson on the importance of reskilling and becoming a lifelong learner.

In an unflinching look at issues that widen the political divide in the US, journalist and editor Bari Weiss highlights why courage is the most important virtue in today's polarized world. She shares examples of people who have spoken up in the face of conformity and silence — and calls on all of us to say what we believe. (Followed by a Q&A with head of TED Chris Anderson)

Are you "too nice" at work? Social psychologist Tessa West shares her research on how people attempt to mask anxiety with overly polite feedback — a practice that's more harmful than helpful — and gives three tips to swap generic, unhelpful observations with clear, consistent feedback, even when you feel awkward.

We tend to celebrate leaders for their dramatic words and actions in times of crisis — but we often overlook truly great leaders who avoid the crisis to begin with. Historian Martin Gutmann challenges us to rethink what effective leadership actually looks like, drawing on lessons from the famed (but disaster-prone) explorer Ernest Shackleton.

What if you could code just by talking out loud? GitHub CEO Thomas Dohmke shows how, thanks to AI, the barrier to entry to coding is rapidly disappearing — and creating software is becoming as simple (and joyful) as building LEGO. In a mind-blowing live demo, he introduces Copilot Workspace: an AI assistant that helps you create code when you speak to it, in any language.