omg OMx Podcast Bruker Daltonics

A new year, a new episode!
In this episode, Sapient’s Tanya Nguen joins us to bring a unique perspective that transcends traditional boundaries, offering valuable insights into treating clinical human diseases. Tanya Nguyen shares insights from her college research in neuroscience, exploring the formative years that shaped her journey. Discover the profound influence of clinical experiences on Tanya's approach to research and how Sapient has provided the opportunity to contribute to science at various stages of drug development.
0:51: The transition from a "non-Omics" background to shaping the future of clinical disease treatment
2:19: Impact of her college research in neuroscience during her formative years
6:13: Connecting research and clinical outcomes: Sapient's role in all stages of drug development 
7:29: Tanya shares her "OMG moment" that set her on the path of scientific exploration
9:02: Significant of mass spectrometry on in the broad Omics field, spanning from early-stage discovery to patient-oriented applications
10:51 - The pivotal role Omics plays at Sapient and the exciting metrics and stats the organization utilizes
13:06 - The future of Omics at Sapient, focusing on ramping up metabolomics, lipidomics, and proteomics to make a lasting impact beyond the genome
18:05 - A glimpse into a day at Sapient and the unique Sapient approach
19:39 🍹 Bonus Content: Discover Tanya’s hobby outside the lab

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2023: Mike Greig's Journey from Chemistry to Mass Spec Magic (omgOMX Finale!)
Thank you for joining us for an exciting year of omgOMX! We're wrapping up 2023 with Bruker's Pharma Biopharma lead, Mike Greig, who shares his incredible journey from a chemistry major to the world of mass spec. 
Join us as he reminisces on:
00:28: Early Days: From polymers (nail polish anyone?) to discovering the magic of mass spec in the pharma industry 
04:39: Influential People: Those who shaped his career and inspired him along the way 
06:47: Mike's OMG Moment: A candied story just in time for Christmas! 
08:07: Drug Discovery Advancements: A glimpse into the ever-evolving landscape 
10:17: The Drug Discovery Pipeline: How it has transformed over time 
12:48: Mass Spec's Crucial Role: How this technology drives innovation in drug discovery 
14:41: Challenges and Solutions: Overcoming obstacles in the pharma biopharma industry 
16:31: Mass Spec Innovation Pipeline: A peek into the future of this powerful technology 
18:42: Getting Up and Running: How mass spec companies help researchers and scientists succeed 
20:29: The Sports Influence: An unexpected connection that inspires 
Don't miss this special episode packed with insights and inspiration!

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In this episode of omgOMX, enter the world of immunopeptidomics with University of Oxford’s Associate Prof. Nicola Ternette. Nicola shares her humble beginnings in virology to becoming a leading expert in the field of immunology. Discover how mass spectrometry opened new doors for protein analysis and vaccine development how Nicola's lab is revolutionizing cancer therapy by profiling immune molecules in different diseases, and how this information can be used to direct clinical applications
Don't miss this inspiring episode that showcases the power of women in science and the potential of immunopeptidomics to shape the future of cancer therapies. Hit that subscribe button and share this episode with fellow science enthusiasts!
00:21 - Nicola's humble beginnings in virology, shaping her path to where she is today
05:48 - Moving to the UK and her exposure to mass spectrometry at Benedict Kessler's proteomics facility
07:43 - Working on HIV vaccines with experts to understand how infected cells appear to the immune system
09:02 - Specializing in profiling immune molecules in diseases and cancer to inform vaccine development
10:00 - The breakthrough realization of applying immune system knowledge to cancer research
10:18 - Focusing on mechanistic research and profiling specific antigens for potential clinical applications
11:29 - Collaboration with industry for cancer therapies and the importance of automation in research
13:09 - Automating the process for analyzing broader sample cohorts and optimizing sample acquisition
14:42 - The challenge of high-throughput analysis and the future of immunopeptidomics
16:38 - The significance of validation in mass spectrometry workflows and antigen identification
21:15 - The impact of the pandemic on vaccine research and its role in cancer therapy
23:53 - Optimism about future advancements in immunopeptidomics and cancer immunotherapy
27:56 - Surprising discoveries and expanding collaborations in industry and clinical partnerships
30:32 - Balancing personal and professional life as an academic researcher

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This episode's guest is no stranger to the single-cell proteomics field. Northeastern University's Nikolai Slavov joins Kate in this interesting discussion that has philosophy intertwined with science. 
Hit the notification button and subscribe to our channel for updates on future episodes and more exciting insights into the fun world of science.
00:36 - Exploring the Humble Beginnings of Nikolai Slavov
10:00 - Discovering His Spin-off Nonprofit, Focused Research Organization (FRO), and Parallel Squared Technology Institute (PTI) to Accelerate Proteome Biology Research
15:03 - Handling Massive Data and Information to Make Scientific Discoveries
19:20 – PTI's Mission and How Mass Spectrometry Influences the Single-Cell Proteomics Space
25:16 - Nikola's "OMG" Moment that Catapulted Him into the World of Science
26:23 – The Power of Mathematics 
28:34 - Nikola's Perspective and Drive to Make Meaningful Contributions to Science
31:28 - A Shoutout to the Incredible Team Behind the Scenes
YouTube: @NikolaiSlavovResearch  

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In this episode of the omg OMx podcast, Pelle Simpson, Senior Scientist at Enveda Biosciences, joins us to share his experiences and how Enveda Biosciences is using natural products to shape drug discovery.
00:39 - Introduction: Pelle's diverse background, from analytical chemistry to 3D printing, electrical engineering to how he joined Enveda Biosciences 
03:18 - Pelle's "OMG" moment: How he got started in natural products drug discovery
05:25 - The significance of Enveda Biosciences within the natural products landscape
07:44 - The role of mass spectrometry and high-throughput screening in drug discovery
11:03 - The diverse sample sources of medicinal plants for research and how Enveda Biosciences expands their library
12:10 - The humble beginnings of Enveda Biosciences: : The CEO's personal experience with herbal medicine and the potential of natural products
13:28 - How Pelle's educational and experiential background influences his work and shaped his approach to industrializing natural products drug discovery.
18:04 - The parallels and differences between academia and industry, and how Enveda Biosciences combines the best of both worlds
19:35 - The art of balancing diverse projects
20:40 - Overcoming innovation blocks, staying inspired and refocused
21:54 - Enveda's strategy of internalizing various aspects natural products space, and what other factors are needed for long-term success
23:48 – 3D printing skills showdown: Kate's timsTOF SCP vs. Pelle's student's ubiquitin protein structure.
Connect with Pelle Simpson on LinkedIn
Explore Enveda Biosciences
Don't forget to like, share, and subscribe for the latest episodes of omg OMx, where we humanize science and get inspired by scientists around the globe.

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Welcome to another exciting episode of omg OMx! In this installment, join Kate Stumpo as she sits down with Balyn Zaro, hailed as the Queen of Sample, from the renowned Zaro Lab at the University of California San Francisco (UCSF). Learn more about the captivating narrative of Balyn's journey and uncover an additional layer of proteomics where sample preparation plays a pivotal role in unleashing endless possibilities.
00:27: Balyn's journey from organic chemistry to chemical biologist, leading to the establishment of Zaro Lab at UCSF
03:32: The influential figures people shaped Balyn's career and provided support along the way.
05:10: The influence of San Francisco's vibrant ecosystem has played on Balyn's ability as a mentor and a scientist.
07:05: Balyn's groundbreaking "omg" moment in mass spectrometry, when her first chemical probe yielded remarkable insights into protein modification.
08:34: The significance of mass spectrometry for biologists and its importance in in advancing scientific research.
10:09: Challenges Balyn faced in the field of mass spectrometry and the innovative tools she used to overcome them.
12:12: Balyn's hopes for advancements in sample preparation technologies such as PreOmics kits and PepSep columns.
14:47: Critical discoveries in innate immunity research, particularly the decision-making processes of macrophages.
16:30: Anticipated breakthroughs and advancements that will shape the next decade of innate immunity research.
19:19: The challenges and intricacies of working with small and precious samples, where microgram quantities can have a significant impact depending on the cell type.
20:27: The importance of incorporating biological knowledge and expertise in method development and experiment training, beyond sample preparation.
20:47: Balyn’s exciting experiments and memorable samples that have fueled her scientific pursuits.
24:13 - Valuable advice on building a fulfilling and successful career, empowering aspiring scientists to navigate their own path with confidence.
26:34 - In Balyn's closing message, experience the joy and fulfillment of working on intriguing projects and the freedom to pursue one's passions within the scientific realm.

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