Science Changing Life Scripps Research

More than 90% of drugs fail to make it from the lab bench to approval. How, then, has a physician-scientist like Hugh Rosen found so much success in developing medicines? Rosen, who’s the chair of molecular and cellular biology at Scripps Research, co-invented the drugs ozanimod (approved for multiple sclerosis and ulcerative colitis) and navacaprant (in Phase 3 trials for major depressive disorder).

In this episode of Science Changing Life, listen in as Rosen unveils the success stories behind these groundbreaking treatments—shedding light on the challenges and triumphs shaping modern medicine.

Rosen Lab: https://www.scripps.edu/rosen/index.html
Scripps Research Magazine: magazine.scripps.edu/

Donna Blackmond never thought her career would lead to solving how life first formed on the prebiotic Earth. But as she points out in this episode of Science Changing Life, does any scientist start out knowing where their research will take them? Blackmond, who is a professor and the John C. Martin Endowed Chair in Chemistry at Scripps Research, shares how her wide-ranging background across chemistry and chemical engineering is helping answer some of today’s biggest questions in science and medicine.

Episode transcript: https://www.scripps.edu/_files/images/2024_images/donna-blackmond-podcast-episode-45-transcript.pdf
Blackmond Lab: https://www.scripps.edu/blackmond/
Blackmond’s recent PNAS and Nature papers: https://www.scripps.edu/news-and-events/press-room/2024/20240228-blackmond-molecules.html
Scripps Research centennial: 100.scripps.edu/
Scripps Research Magazine: magazine.scripps.edu/

Dr. Jay Pandit is a director of digital medicine at the Scripps Research Translational Institute and an assistant professor in the Department of Molecular Medicine at Scripps Research, where he combines medicine and technology to improve patients’ clinical outcomes. Listen in as we explore how biosensors and wearable technologies are enabling users to take control of their own health data and usher in a new era of personalized medicine.

Episode transcript: https://www.scripps.edu/_files/images/2024_images/jay-pandit-transcript.pdf
X: https://twitter.com/JayPandit
LinkedIn: www.linkedin.com/in/jay-pandit-9489008
Scripps Research centennial: https://100.scripps.edu/
Scripps Research Magazine: https://magazine.scripps.edu/

Ahmed Badran is an assistant professor of chemistry at Scripps Research, where his lab harnesses synthetic biology to address some of biggest global problems. Listen in as we discuss reengineering plant enzymes to capture carbon, plastic-eating bacteria and new classes of antibiotics that spare our gut microbiome.

Episode transcript: https://www.scripps.edu/_files/images/2023_images/ahmed-badran-transcript.pdf

Badran lab website
https://badranlab.com/

Twitter
@AhmedHBadran

Scripps Research Magazine
https://magazine.scripps.edu/

Professor Mia Huang is based in the Department of Molecular Medicine at Scripps Research, where her lab explores how vital sugar molecules in the body orchestrate complex biological events. Listen in as we discuss deciphering cancer cell signals to develop new therapies, engineering red blood cells for transfusions and how to become a master of strategy.

Episode transcript: https://www.scripps.edu/_files/images/2023_images/mia-huang-transcript.pdf

Huang lab website
https://www.huangresearch.com/

Q&A with Mia
https://magazine.scripps.edu/profiles/2020/fall/science-with-a-view-understanding-how-natures-biomolecules-tick-with-mia-huang/

Twitter
@HuangMia

Scripps Research Magazine
https://magazine.scripps.edu/

Professor Ram Krishnamurthy is based in the Department of Chemistry at Scripps Research, where his lab investigates the reactions that could have first given way to life on Earth. Listen as we discuss finding biological building blocks on meteorites, NASA’s search for life on other planets, and staying grounded with philosophy and meditation.

Episode transcript
https://www.scripps.edu/_files/images/2023_images/ram-krishnamurthy-transcript.pdf

Ram’s faculty profile
https://www.scripps.edu/faculty/krishnamurthy/

Astrobiology at NASA
https://astrobiology.nasa.gov/news/new-nasa-research-consortium-to-tackle-lifes-origins/

Scripps Research Magazine
https://magazine.scripps.edu/