189 episodes

This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss.

This Week in Cardiology Medscape

    • Science

This podcast delivers Dr. John Mandrola’s summary and perspective on top news of the week that cardiologists can’t miss.

    Oct 22, 2021 This Week in Cardiology Podcast

    Oct 22, 2021 This Week in Cardiology Podcast

    Aspirin for primary prevention, induced hypothermia, half-dose DOAC, and social media, are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
    I - ASA for Primary Prevention
    - USPSTF Rules Out Aspirin for Over 60s in Primary CVD Prevention https://www.medscape.com/viewarticle/960745
    - Aspirin Use to Prevent Cardiovascular Disease: Preventive Medication https://www.uspreventiveservicestaskforce.org/uspstf/document/draft-evidence-review/aspirin-use-to-prevent-cardiovascular-disease-preventive-medication
    - Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)31924-X/fulltext
    - Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus https://www.nejm.org/doi/full/10.1056/nejmoa1804988
    - Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/NEJMoa1805819
    - Effect of Aspirin on All-Cause Mortality in the Healthy Elderly https://www.nejm.org/doi/full/10.1056/nejmoa1803955
    II - Induced Hypothermia
    - No Benefit From Lower Temps for Out-of-Hospital Cardiac Arrest https://www.medscape.com/viewarticle/961191
    - The CAPITAL CHILL Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2785263
    - Targeted Temperature Management at 33°C versus 36°C after Cardiac Arrest https://www.nejm.org/doi/10.1056/NEJMoa1310519
    - Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest https://www.nejm.org/doi/full/10.1056/NEJMoa2100591
    III - Half-dose DOAC
    - Half-Dose DOACs Cut Bleeding, Thrombus Risk Post-Watchman LAA Closure https://www.medscape.com/viewarticle/960974
    - Half-Dose Direct Oral Anticoagulation Versus Standard Antithrombotic Therapy After Left Atrial Appendage Occlusion https://www.jacc.org/doi/full/10.1016/j.jcin.2021.07.031
    IV - Social Media
    - Navigating Benefits, Pitfalls of Social Media as a Female Doctor https://www.medscape.com/viewarticle/961150
    - Gender Differences in Physician Use of Social Media for Professional Advancement https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2779868
    Features:
    - USPSTF Statement on Aspirin: Poor Messaging at Best https://www.medscape.com/viewarticle/961118
    You may also like:
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    Questions or feedback, please contact news@medscape.net

    • 24 min
    Oct 8, 2021 This Week in Cardiology Podcast

    Oct 8, 2021 This Week in Cardiology Podcast

    Two NEJM papers on mRNA-related myocarditis, AF and stroke, intensifying BP meds, and CCTA and high-sensitivity troponin are the topics John Mandrola, MD, covers in this week's podcast. To read a partial transcript or to comment, visit:
    https://www.medscape.com/twic
    I -- Vaccine-Induced Myocarditis
    New Reports Help Nail Down Myocarditis Risk With COVID-19 Vaccine
    https://www.staging.medscape.com/viewarticle/960537
    • Myocarditis after BNT162b2 mRNA Vaccine against Covid-19 in Israel
    https://www.nejm.org/doi/full/10.1056/NEJMoa2109730
    • Myocarditis after Covid-19 Vaccination in a Large Health Care Organization
    https://www.nejm.org/doi/full/10.1056/NEJMoa2110737
    II – AF and Stroke
    AF a Stroke Cause or Innocent Bystander? The Debate Continues
    https://www.medscape.com/viewarticle/960224
    • Temporal Association Between Episodes of Atrial Fibrillation and Risk of Ischemic Stroke
    https://jamanetwork.com/journals/jamacardiology/fullarticle/2784332
    • It's Time to Rethink (and Retrial) Our Framework for Stroke Prevention in Atrial Fibrillation
    https://jamanetwork.com/journals/jamacardiology/fullarticle/2784335
    III- Intensification of BP Control
    Adding New Hypertensive May Be More Potent Than Upping Doses
    https://www.medscape.com/viewarticle/960454
    • Adding a New Medication Versus Maximizing Dose to Intensify Hypertension Treatment in Older Adults
    https://doi.org/10.7326/M21-1456
    IV- Hs-troponin and CAD
    Troponin Levels Tied to Increased CAD Risk, May Guide Imaging /viewarticle/960146
    • Troponin-Guided Coronary Computed Tomographic Angiography After Exclusion of Myocardial Infarction
    https://doi.org/10.1016/j.jacc.2021.07.055
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    https://www.medscape.com/features/public/machine
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    https://www.medscape.com/author/bob-harrington
    Questions or feedback, please contact
    news@medscape.net

    • 23 min
    Oct 1, 2021 This Week in Cardiology Podcast

    Oct 1, 2021 This Week in Cardiology Podcast

    Coronary artery calcification and exercise, translating clinical trials, the question of metabolically healthy obesity, and Watchman complications are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
    I - CAC and Physical Activity
    - Physical Activity Paradoxically Tied to Higher Coronary Calcium https://www.medscape.com/viewarticle/959366
    - Physical activity and the progression of coronary artery calcification http://dx.doi.org/10.1136/heartjnl-2021-319346
    II - Translating Clinical Trials
    - SYNTAX Score II 2020 Wobbles in Real-World Validation https://www.medscape.com/viewarticle/958834
    - Redevelopment and validation of the SYNTAX score II to individualise decision making between percutaneous and surgical revascularisation in patients with complex coronary artery disease: secondary analysis of the multicentre randomised controlled SYNTAXES trial with external cohort validation https://doi.org/10.1016/S0140-6736(20)32114-0
    - External Validation of the SYNTAX Score II 2020 https://www.jacc.org/doi/full/10.1016/j.jacc.2021.07.027
    III - Healthy and Obesity
    - ‘Metabolically Healthy Obesity’ Has Heart Risks. Is it a Misnomer? https://www.medscape.com/viewarticle/959994
    - Metabolically healthy obesity and cardiovascular events: A nationwide cohort study https://doi.org/10.1111/dom.14492
    - Relation of Obesity to New-Onset Atrial Fibrillation and Atrial Flutter in Adults https://pubmed.ncbi.nlm.nih.gov/29501206/
    - Paediatric obesity appears to lower the risk of diabetes if selection bias is ignored https://pubmed.ncbi.nlm.nih.gov/29374028
    IV - Watchman Complications
    - FDA Investigating Potential Sex Differences in LAAO Adverse Outcomes https://www.medscape.com/viewarticle/959806
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    Questions or feedback, please contact news@medscape.net

    • 23 min
    Sep 24, 2021 This Week in Cardiology Podcast

    Sep 24, 2021 This Week in Cardiology Podcast

    Dual antiplatelet therapy after PCI, statin side effects, nightshift work and AF, and a cautionary note regarding therapeutic enthusiasm in HF care are the topics John Mandrola, MD, discusses in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
    I - COVID
    - Alaska Sets Record for Daily COVID Cases https://www.medscape.com/viewarticle/958999
    II - MASTER DAPT
    - MASTER DAPT: 1 Month DAPT Enough After High-Bleeding-Risk PCI https://www.medscape.com/viewarticle/957463
    - Antiplatelets and Anticoagulation Post-PCI: More on MASTER DAPT https://www.medscape.com/viewarticle/958002
    - Dual Antiplatelet Therapy after PCI in Patients at High Bleeding Risk https://www.nejm.org/doi/full/10.1056/NEJMoa2108749
    - Abbreviated Antiplatelet Therapy in Patients at High Bleeding Risk With or Without Oral Anticoagulant Therapy After Coronary Stenting: An Open-Label, Randomized, Controlled Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.121.056680
    III - Statins and Side Effects
    - Most Muscle Pain on Statins Not a Drug Effect: SAMSON in Print https://www.medscape.com/viewarticle/958877
    - Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment https://doi.org/10.1016/j.jacc.2021.07.022
    IV - Nightshift Work and AF
    - Regular Nightshift Work Linked to Atrial Fibrillation, CHD https://www.medscape.com/viewarticle/959346?src=
    - Long-term night shift work is associated with the risk of atrial fibrillation and coronary heart disease https://doi.org/10.1093/eurheartj/ehab505
    V - Enthusiasm for HF Therapy
    - Empagliflozin's HFpEF Efficacy Catalyzes Redefinition of HF https://www.medscape.com/viewarticle/959249
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    The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD https://www.medscape.com/author/bob-harrington
    Questions or feedback, please contact news@medscape.net

    • 26 min
    Sep 17, 2021 This Week in Cardiology Podcast

    Sep 17, 2021 This Week in Cardiology Podcast

    Cardiac arrest care, finerenone, carotids, meds post TAVI: less is more and the new may not be as grand as the tried and true. John Mandrola, MD, provides a third ESC review. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
    I - Cardiac Arrest Care
    - Angiography Can Wait for Cardiac Arrest Without ST-Elevation https://www.medscape.com/viewarticle/957471
    - Angiography after Out-of-Hospital Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/full/10.1056/NEJMoa2101909
    - Coronary Angiography after Cardiac Arrest without ST-Segment Elevation https://www.nejm.org/doi/full/10.1056/NEJMoa1816897
    II - Finerenone
    - FIDELITY: Finerenone Cuts CV Risk in T2D Across CKD Spectrum https://www.medscape.com/viewarticle/957470
    - Cardiovascular Events with Finerenone in Kidney Disease and Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2110956
    - Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes https://www.nejm.org/doi/full/10.1056/NEJMoa2025845
    III - Carotid Intervention
    - ACST-2: Carotid Stenting, Surgery on Par in Asymptomatic Patients https://www.medscape.com/viewarticle/957474
    - Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy https://doi.org/10.1016/S0140-6736(21)01910-3
    IV - Post TAVI DOAC
    - 'Less Is More' for Edoxaban in Post-TAVI Anticoagulation: ENVISAGE-TAVI AF https://www.medscape.com/viewarticle/957466
    - Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR https://www.nejm.org/doi/full/10.1056/NEJMoa2111016
    - ATLANTIS Hints at How to Choose Post-TAVR Antithrombotics https://www.medscape.com/viewarticle/951234
    - A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement https://www.nejm.org/doi/full/10.1056/NEJMoa1911425
    Features:
    - What Are the Implications of ACST-2 for Patients With Asymptomatic Carotid Stenosis? https://www.medscape.com/viewarticle/957502
    - Top 5 Studies From ESC 2021 https://www.medscape.com/viewarticle/958598
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    The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD https://www.medscape.com/author/bob-harrington
    Questions or feedback, please contact news@medscape.net

    • 25 min
    Sep 10, 2021 This Week in Cardiology Podcast

    Sep 10, 2021 This Week in Cardiology Podcast

    ESC Wrap-up Part II: EMPEROR-Preserved, and the STEP, Guide-HF, and IAMI trials, are discussed by John Mandrola, MD, in this week’s podcast. To read a partial transcript or to comment, visit: https://www.medscape.com/twic
    I - HFpEF
    - EMPEROR-Preserved: Empagliflozin Scores HFpEF Breakthrough https://www.medscape.com/viewarticle/957405
    - Empagliflozin in Heart Failure with a Preserved Ejection Fraction https://www.nejm.org/doi/full/10.1056/NEJMoa2107038
    II - BP Targets
    - STEP: Lowering Blood Pressure Below 130 mm Hg Shows CV Benefit https://www.medscape.com/viewarticle/957566
    - Trial of Intensive Blood-Pressure Control in Older Patients with Hypertension https://www.nejm.org/doi/full/10.1056/NEJMoa2111437
    III- PA Catheter Monitoring
    - GUIDE-HF: CardioMEMS-Guided Meds Fall Short in Mild to Moderate Heart Failure https://www.medscape.com/viewarticle/957390
    - Haemodynamic-guided management of heart failure (GUIDE-HF): a randomised controlled trial https://doi.org/10.1016/S0140-6736(21)01754-2
    - Wireless pulmonary artery haemodynamic monitoring in chronic heart failure: a randomised controlled trial https://doi.org/10.1016/S0140-6736(11)60101-3
    IV - Influenza Vaccine
    - Seasonal Flu Vax Cuts Post-MI Mortality in IAMI Trial https://www.medscape.com/viewarticle/957575
    - Influenza Vaccination after Myocardial Infarction: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial https://doi.org/10.1161/CIRCULATIONAHA.121.057042
    - Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis https://pubmed.ncbi.nlm.nih.gov/20332404/
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    The Bob Harrington Show with Stanford University Chair of Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
    Questions or feedback, please contact news@medscape.net

    • 21 min

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