Fight off the Effects of Ageing Using Oxaloacetate with Alan Cash Pushing The Limits

In this episode, Alan Cash talks about oxaloacetate and the beginning of his journey in developing it as a nutritional supplement. He shares the ongoing research on oxaloacetate's benefits, especially for patients suffering from brain damage. He also dives into oxaloacetate's ability to increase muscle use before fatigue and reduce anxiety and depression levels in women experiencing PMS.
If you want to learn more about oxaloacetate's many benefits and applications, then this episode is for you!
Here are three reasons why you should listen to this episode: Learn what oxaloacetate is and how it can help slow the biological effects of ageing. Discover the numerous potential health benefits of oxaloacetate. Get to know Alan’s journey in developing and manufacturing oxaloacetate as a nutritional supplement.  
Episode Highlights [09:36] How Alan Found Out About Oxaloacetate Alan got sick and needed to undergo brain surgery. He found out that his pain and illness were related to ageing.
As Alan researched more about ageing, he discovered calorie restriction, wherein organisms tend to live longer when they eat less.
Increasing the ratio of Nicotinamide Adenine Dinucleotide (NAD) to NADH helps fight off ageing.
Alan started looking into biomechanical pathways and found that oxaloacetate that can change the ratio of NAD from NADH to 900% in just two minutes. He started testing oxaloacetate using worms and realised that the activated pathway was the same as calorie restriction.
[21:53] What is Oxaloacetate? Oxaloacetate is a naturally occurring molecule in our bodies during metabolism. It exists in every cell of the body and, therefore, is non-toxic.
Oxaloacetate is considered a hot molecule right now, given how it can help moderate metabolism on a cell-by-cell basis. Increasing oxaloacetate affects metabolism, which is vital to some people.
[25:38] Patenting Oxaloacetate  Tohoku University in Sendai, Japan, conducted research in the 1960s which found how oxaloacetate reduced fasting glucose levels in type one and type two diabetics. 
At first, Alan ran into the problem of being unable to get a patent for oxaloacetate, a naturally occurring compound in the human body. He persevered and eventually was able to own patent rights based on how oxaloacetate can maintain its stable form of enol-oxaloacetate. 
After rigorous testing, their products now have a shelf life of two to three years or more.
[31:00] Oxaloacetate and the Warburg Effect Oxaloacetate is a potential drug for brain cancer such as glioblastoma. It also has the potential to reverse the Warburg effect, in which fermented glucose turns into lactate that a tumour feeds off.
Giving Oxaloacetate to cancer cells changes the cancer metabolism cell by cell. There’s a specific dosage where cancer cells stop reproducing.
[38:03] Oxaloacetate and Glutamate Glutamate is a compound that fires off the neutrons in the brain. Excessive glutamate excites the neurons until they die, a process known as excitotoxicity. Many studies describe how we may reduce the risk of excitotoxicity. 
Alan is looking into cognition through clinical trials with Alzheimer’s disease patients. The study showed how oxaloacetate reduced glutamate levels. In the same clinical trial, they also found how oxaloacetate increased the amount of glucose the brain can take in.
The brain can take in more glucose due to the signalling protein PGC-1 Alpha enabling the production of more mitochondria.
[38:03] Oxaloacetate Can Improve Muscle Use Oxaloacetate also improves muscle use by 10% more before it goes into fatigue. 10% is a significant improvement for both top-end athletes and daily living.
Alan has done a clinical trial that showed a 25% to 30% drop in fatigue levels within six weeks, even for people with chronic fatigue syndrome or ME/CFS for up to 30 years. NF-κB turns on genes that release a cytokine storm, which at high levels can lead to chronic inflammation seen in arthritis or l