100 episodes

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

Fundamental Health with Paul Saladino, MD Paul Saladino, MD

    • Medicine
    • 5.0 • 13 Ratings

Throughout my training and practice as a physician I have come to one very disappointing conclusion: Western medicine isn’t helping people lead better lives. Now that I’ve realized this, I’ve become obsessed with understanding what makes us healthy or ill. I want to live the best life I can and I want to be able to share this knowledge with others so that they can do the same. This podcast is the result of my relentless search to understand the roots of chronic disease. If you want to know how to live the most radical life possible I hope you’ll join me on this journey.

    Controversial Thoughts: How is an Animal-Based diet different than a Paleo diet?

    Controversial Thoughts: How is an Animal-Based diet different than a Paleo diet?

    Animal-based vs Keto vs Paleo
    Though at first glance an #Animalbased diet may look like a ketogenic or paleo diet, there are some key differences. Though a paleo diet includes meat, this type of eating forgets about the incredible nutrient richness found in organs like liver, heart, kidney, etc. A paleo diet also leaves in nuts/seeds/and leafy greens which don't really provide any unique nutrients but do lead to a lot of gas 💨, bloating, and digestive issues for many people. These are full of anti-nutrients and digestive enzyme inhibitors and are best avoided.
    Though a very low carbohydrate ketogenic diet can be incredibly powerful for many people with diabetes, and obesity, this way of eating isn't really sustainable long term.
    The fact of the matter is this, eliminating carbs can help with insulin resistance but didn't cause it in the first place. To truly treat these issues we must remove seed oils and excess linoleic acid from our diets. Once you are metabolically healthy, including carbohydrates from the least toxic plant sources (sweet/non-sweet fruit- no fructose is not toxic in fruit) can be a positive addition to your diet!
    Animal-based diets can take many forms to suit your needs, but don't fall into overly rigid ketogenic dogma by fearing all carbohydrates long term. Cycling in low-carb periods or periods of a carnivore diet is great, but it's also nice to bring in a few low toxicity plant foods from time to time for variety, flavor, color, etc. Just know that if you chose to include nuts/seeds/leafy greens you may run into digestive issues by trending too much toward paleo.
    Here's to reclaiming your birthright to radical health! #theremembering
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    • 18 min
    The Omega-6 Apocalypse, are seed oils to blame for diabetes, heart attacks, and chronic disease ?

    The Omega-6 Apocalypse, are seed oils to blame for diabetes, heart attacks, and chronic disease ?

    Dr. Knobbe began his practice of ophthalmology in 1994, after completing his residency training at the University of Colorado Health Sciences Center, in Denver, Colorado, USA. He was certified by the American Board of Ophthalmology in 1997 and has remained board-certified since then.
    Eye physician and surgeon, Chris A. Knobbe, MD, had been in practice nearly 20 years when, in 2013, he asked himself the question, “Could macular degeneration be a ‘Westernized disease’? Could AMD be a disease that is the result of a Westernized diet?” That question would forever change his life.
    The hypothesis that Dr. Knobbe would proffer holds that macular degeneration, which is the leading cause of irreversible vision loss and blindness in developed nations, is not only preventable but treatable in the early to moderate stages, with an ancestral diet.
     
    Time Stamps: 
    0:09:24 Podcast Begins
    0:12:39 200 years of nutritional research
    0:23:09 Needs a title 60-sec audiogram
    0:30:09 Timeline for Processed Food Introductions
    0:36:44 Non-negotiable: Animal fats are essential
    0:44:17 150 years of Vegetable Oil Consumption
    0:49:07 Who's the real culprit?
    0:51:46 Heart Disease Deaths vs Sturated fat and Vegetable Oil
    1:05:32 Can linoleic acid contribute to coronary artery disease? https://www.researchgate.net/publication/15005994_Can_linoleic_acid_contribute_to_coronary_artery_disease
    1:08:12 Why do we blame the carbs?
    1:11:35 Sweden vs US adipose Linoleic Acid and obesity
    1:14:02 The Case Of Japan
    1:27:20 The problem is neither calories nor carbs
    1:33:49 Is processed sugar harmful in and of itself? | What carbs to eat
    1:43:36 The Case Of Okinawa
    1:55:41 Diets could prevent many diseases Https://www.researchgate.net/publication/10673140_Diets_could_prevent_many_diseases
    2:02:50 Lowering dietary linoleic acid reduces bioactive oxidized linoleic acid metabolites in humans https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467319/
    2:03:29 Unsaturated fatty acids and their oxidation products stimulate CD36 expression in human macrophages https://www.researchgate.net/publication/11260045_Unsaturated_fatty_acids_and_their_oxidation_products_stimulate_CD36_expression_in_human_macrophages
    2:04:13 Low-density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC54010/
    2:06:00 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://www.researchgate.net/publication/12880728_A_high_linoleic_acid_diet_increases_oxidative_stress_in_vivo_and_affects_nitric_oxide_metabolism_in_humans
    2:10:50 Changes in Dietary Fat Intake Alter Plasma Levels of Oxidized Low-Density Lipoprotein and Lipoprotein(a) https://www.ahajournals.org/doi/10.1161/01.atv.0000118012.64932.f4
    2:11:39 Where to find Chris Knobbe
    --
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    Sacred Hunting: www.sacredhunting.com/paul for $250 off of your hunt

    • 2 hrs 20 min
    Controversial Thoughts: Could coffee worsen fibromyalgia? And other reasons to avoid it on an Animal-Based diet.

    Controversial Thoughts: Could coffee worsen fibromyalgia? And other reasons to avoid it on an Animal-Based diet.

    What could be more controversial than suggesting that coffee might not be the elixir of life it’s cracked up to be?

    • 34 min
    How to have the best poop of your life. Lucy Mailing PhD returns!

    How to have the best poop of your life. Lucy Mailing PhD returns!

    Lucy Mailing, Ph.D. received her Bachelor’s in Biology from Kalamazoo College and her Ph.D. in Nutritional Sciences from the University of Illinois, where her dissertation research focused on the effects of diet and exercise on the gut microbiome in states of health and disease. Lucy has authored several peer-reviewed journal articles related to the microbiome and health and was named an Emerging Leader in Nutritional Sciences by the American Society for Nutrition in 2017. Lucy has also served as a staff research associate for the Kresser Institute for Functional and Evolutionary Medicine since 2015.
    Lucy is the founder and sole author of lucymailing.com, a site dedicated to evidence-based articles about the microbiome, gut and skin health, and nutrition. She is regularly invited to speak on gut health around the country and has been recognized as one of the most trusted experts in the integrative health space. Lucy plans to continue her academic training and begin a postdoc in 2020 after a gap year dedicated to writing and other projects. 
    Time Stamps: 
    0:08:47 Podcast begins
    0:09:55 What is a healthy gut microbiome?
    0:12:43 The Microbiome of the Hadza
    0:14:25 Enterocyte-Associated Microbiome of the Hadza Hunter-Gatherers https://www.frontiersin.org/articles/10.3389/fmicb.2016.00865/full
    0:18:36 Figure: Typical major phyla and genera of the human gut microbiome https://www.researchgate.net/figure/Typical-major-phyla-and-genera-of-the-human-gut-microbiome-reproduced-with-permission_fig1_331990159
    0:22:05 Seasonal cycling in the gut microbiome of the Hadza hunter-gatherers of Tanzania https://science.sciencemag.org/content/357/6353/802#:~:text=The%20data%20reveal%20annual%20cyclic,reappear%20in%20a%20subsequent%20season.&text=These%20data%20indicate%20that%20some,and%20abundance%20in%20modernized%20populations.
    0:24:38 Pervasive bias in research
    0:30:10 Gut microbiome of the Hadza hunter-gatherers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3996546/
    0:31:11 Microbiological dark matter and the infancy of gut microbiology
    0:38:17 The Story of Butyrate
    0:42:19 Mitochondrial dysfunction in inflammatory bowel disease alters intestinal epithelial metabolism of hepatic acylcarnitines https://www.jci.org/articles/view/133371
    0:44:04 Figure: Cartoon of the acylcarnitine shuttle and β-oxidation of fatty acids in mitochondria. https://www.researchgate.net/figure/Cartoon-of-the-acylcarnitine-shuttle-and-b-oxidation-of-fatty-acids-in-mitochondria_fig1_323380097
    0:46:00 GUT MICROBIAL METABOLOME: REGULATION OF HOST METABOLISM BY SCFAs https://core.ac.uk/download/pdf/77011125.pdf
    0:47:50 Fermentation of animal components in strict carnivores: A comparative study with cheetah fecal inoculum https://www.researchgate.net/publication/221789283_Fermentation_of_animal_components_in_strict_carnivores_A_comparative_study_with_cheetah_fecal_inoculum
    0:52:50 Diet rapidly and reproducibly alters the human gut microbiome https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957428/
    0:55:42 An Expanded Genetic Code Enables Trimethylamine Metabolism in Human Gut Bacteria https://msystems.asm.org/content/5/5/e00413-20/article-info
    0:55:42 How animal-based diet's produce risk of cardiovascular disease
    0:58:50 No effect of plasma trimethylamine N-Oxide (TMAO) and plasma trimethyllysine (TML) on the association between choline intake and acute myocardial infarction risk in patients with stable angina pectoris https://www.sciencedirect.com/science/article/pii/S2666149720300025
    1:00:27 L-Carnitine Supplementation Increases Trimethylamine-N-Oxide but not Markers of Atherosclerosis in Healthy Aged Women https://www.karger.com/Article/Abstract/495037
    1:03:12 Ketogenic Diets > High Fiber Diets
    1:03:12 Ketogenic Diets Alter the Gut Microbiome Resulting in Decreased Intestinal Th17 Cells https://www.cell.com/cell/fulltext/S0092-8674(20)3

    • 2 hrs 14 min
    Controversial thoughts: Which alcohol is the least toxic? And how to fix a hangover!

    Controversial thoughts: Which alcohol is the least toxic? And how to fix a hangover!

    Happy New Year to all! 
    I’m not a drinker, but I know there are many who will be enjoying alcohol to celebrate the end of this crazy year, and the beginning of one we all hope will be a bit better than 2020.
    If you’re going to imbibe at New Years or any other time, what’s the least toxic sauce to consume? Find out in this Controversial Thoughts video along with why alcohol causes a hangover and what you can do to mitigate it prior and ameliorate it once it’s besieged you. Hint:  these answers may have to do with things I’ve discussed before like avoiding toxic seed oils to limit lipid peroxidation in your liver from alcohol byproducts, and making sure to get enough nutrients into your diet on a daily basis to optimize your glutathione and NAD/NADH statuses. 
    If you’re looking to lose weight, or kick more ass in 2021 you should join us at Heart & Soil for our 30 day animal based reset in January. Go to www.AnimalBased30.com to sign up and become part of the tribe that will be starting off the new year right! There will be lots of content, support, and a chance to win some of our desiccated organ supplements as well as signed copies of my book, The Carnivore Code. Welcome to #theremembering.

    • 26 min
    How to make your immune system strong as heck, Part 2 with James DiNicolantionio, Pharm D

    How to make your immune system strong as heck, Part 2 with James DiNicolantionio, Pharm D

    Find part 1 of this podcast with James, here. 
     
    Dr. James DiNicolantonio, is a Doctor of Pharmacy and a cardiovascular research scientist. A well-respected and internationally known scientist and an expert on health and nutrition, he has contributed extensively to health policy and has testified in front of the Canadian Senate regarding the harms of added sugars. He serves as the associate editor of the British Medical Journal’s Open Heart, a journal published in partnership with the British Cardiovascular Society, and is on the editorial advisory boards of several other medical journals. Dr. DiNicolantonio is the author or coauthor of over 250 publications in the medical literature. He also is the author of three bestselling health books, The Salt Fix, Superfuel and The Longevity Solution, as well as his newest book, The Immunity fix which you can find here. You can follow him on Instagram and Twitter @drjamesdinic and on Facebook at Dr. James DiNicolantonio. You can visit his website at drjamesdinic.com.



    Time stamps: 
     
    0:08:11 Podcast begins 
    0:09:16 How to create metabolic health 
    0:16:54 A high linoleic acid diet increases oxidative stress in vivo and affects nitric oxide metabolism in humans https://linkinghub.elsevier.com/retrieve/pii/S0952-3278(98)90067-9 
    0:19:55 Omega six fatty acids and oxidative stress 
    0:21:07 Premature atherosclerosis associated with monogenic insulin resistance https://www.ahajournals.org/doi/10.1161/01.cir.103.18.2225?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 
    0:22:00 Elevated Serum C-Reactive Protein and Free Fatty Acids Among Nondiabetic Carriers of Missense Mutations in the Gene Encoding Lamin A/C (LMNA) With Partial Lipodystrophyhttps://www.ahajournals.org/doi/10.1161/01.atv.0000047460.27435.b8?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed 
    0:32:46 Answering the fructose question and dispelling keto dogma 
    0:40:17 What nutrients are required for robust immunity 
    0:40:17 Is colostrum more effective than vaccines? 
    0:41:56 Prevention of Influenza Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentinohttps://journals.sagepub.com/doi/10.1177/1076029606295957?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed& 
    0:43:07 Prevention of flu episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study https://www.minervamedica.it/en/journals/panminerva-medica/article.php?cod=R41Y2010N04A0269 
    0:48:05 Some other helpful interventions 
    0:52:59 All about environmental hormesis 
    0:57:48 James' thoughts on time-restricted eating 
    1:42:35 Where to find James DiNicolantonio http://drjamesdinic.com/
     
    Heart & Soil: www.heartandsoil.co 
     
    White Oak Pastures: www.whiteoakpastures.com code CarnivoreMD for 10% off first order
     
    Belcampo: www.belcampo.com code CarnivoreMD for 20% off
     
    Let’s Get Checked:  www.trylgc.com/carnivoremd 

    BluBlox: www.blublox.com, CarnivoreMD for 15% off

    • 1 hr 4 min

Customer Reviews

5.0 out of 5
13 Ratings

13 Ratings

Ademr2 ,

I want to hug this man!!

Paul gives lots of great evidence based information. After listening to his podcasts, and changing the way we eat, my husband and I are loosing weight, improving our metabolic health, and feel better in our 50s than for decades. We highly recommend anyone to have a listen, give it a try, and decide for yourself. Thanks Paul!! You have helped change our lives!

Olliesaunt ,

Great info for those with autoimmune disease or gut issues

Great info for those with autoimmune disease or gut issues. It turns out that some plants can really do damage in some people. I was one of them. Cutting out many plant foods has greatly reduced my pain and Saladino explores the mechanisms behind this.

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