The Empowering Neurologist Podcast David Perlmutter

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In a groundbreaking development, an international team of researchers has unveiled a remarkable advancement in the fight against progressive multiple sclerosis (MS). Their study, led by scientists from the University of Cambridge, the University of Milan Bicocca, and Hospital Casa Sollievo della Sofferenza in Italy, demonstrates the safety, tolerance, and long-lasting effectiveness of injecting a specific type of stem cell directly into the brains of patients living with progressive MS. This breakthrough paves the way for the development of advanced cell therapy treatments for this debilitating disease that affects over 2 million people worldwide.



Multiple sclerosis is a complex autoimmune disease that targets the central nervous system, leading to severe disruption in the transmission of nerve signals. While there are treatments available to alleviate some of the symptoms and reduce the frequency of relapses, many patients still progress into a secondary phase of the disease, which steadily worsens over time, causing severe disability. This secondary progressive phase has long been a significant challenge in the treatment of MS.



In progressive forms of MS, a type of immune cell known as macrophages, specifically microglial cells, plays a crucial role in attacking and damaging the central nervous system. This relentless assault leads to chronic inflammation and extensive nerve cell damage. Recent advances in stem cell therapies have raised hope that they could help mitigate this damage by replacing damaged cells with healthy ones.



Before the current study, the University of Cambridge team had already demonstrated in mouse models that reprogrammed skin cells into brain stem cells, transplanted into the central nervous system, could reduce inflammation and potentially aid in repairing MS-related damage.



This groundbreaking study marks a significant step forward in the pursuit of effective treatments for secondary progressive MS. Although the study is relatively small and may have confounding effects from immunosuppressant drugs, its safety and long-lasting effects over the 12-month trial period have paved the way for further clinical trials. The research team's cautious optimism fuels hope for the development of cell therapy as a potential solution for this debilitating condition. This exciting progress holds the promise of a brighter future for the millions of people living with progressive MS, offering renewed hope for a more effective treatment approach.



Our interview today is with the lead researcher involved in this study at the University of Cambridge, Stefano Pluchino, MD, PhD.



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0:00 Intro

2:46 Why Stem Cell Therapy Works

5:10 Studying Stem Cells on the Brain

9:15 MS Patients Studied in This Trial 

13:43 What the Results Mean for the Public

17:40 The Specifics of the Study

26:18 Rigorous Testing that Sets this Trail Apart

28:25 Findings: Feasibility, Safety, and Biomarkers 

34:32 Looking at the Results over 12 months

40:11 Correlation of Metabolic Health and MS

44:55 What Exosomes Reveal About Disease

49:01 Senolytic Therapy & Neurodegenerative Diseases

53:36 Conclusion 

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Stefano Pluchino received his MD and PhD degrees at the University of Siena, Italy,

and additional training at Cambridge University, UK. He is currently Professor of

Regenerative Neuroimmunology (2021) and Honorary Consultant in Neurology, within

the Department of Clinical Neurosciences at Cambridge University.



Twitter: @Pluchinolab

Research: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(23)00393-4



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In this episode of The Empowering Neurologist, we're diving into two topics that are gaining significant attention in the worlds of men's health and weight loss: the importance of testosterone replacement therapy and the emerging role of GLP-1 agonists in weight loss as well as in diabetes treatment. Joining us is an esteemed expert in this field, Dr. Tracy Gapin, a renowned urologist and men's health specialist.

Why is this topic so crucial? Testosterone, often hailed as the cornerstone of male vitality, plays a central role in various aspects of men's health. It's not just about physical strength or libido; testosterone impacts mood, energy levels, bone density, muscle mass, cognitive function, and overall well-being. However, as men age, testosterone levels naturally decline, leading to a condition known as hypogonadism or low testosterone. This decline can have profound effects on a man's health and quality of life.

Dr. Gapin, with his extensive experience and research in the field, sheds light on how testosterone replacement therapy can be a game-changer for men experiencing the effects of low testosterone. He delves into the nuances of identifying candidates for this therapy, the benefits, and the misconceptions surrounding it. His insights are particularly valuable in a time when discussions about men's hormonal health are often overshadowed or misunderstood. Further, as he explains, age-matched testosterone levels in men have plummeted over the past several decades, and we discuss why.

In addition, Dr. Gapin takes us through the exciting world of GLP-1 agonists, a class of drugs initially developed for diabetes management but now having a major impact in the weight loss arena. Obesity is a mounting concern globally, and its impact on men's health is undeniable. With cardiovascular disease, diabetes, and a host of other conditions linked to obesity, finding effective weight management solutions is paramount. Dr. Gapin explains how GLP-1 agonists work, their benefits, their potential risks, and their role in revolutionizing weight loss treatments.

This episode is not just for those directly experiencing these issues but also for anyone interested in the broader conversation about men's health. Whether you're a healthcare professional, someone exploring options for personal health improvement, or simply curious about the latest in medical advancements, Dr. Gapin's insights offer valuable knowledge and perspective.



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0:00 Intro

3:04 The Issues of Low Testosterone

7:07 Why Testosterone Levels are Falling

10:00 What Indicates Low Testosterone

15:00 The Holistic Approach to This

17:28 Why Testosterone Replacement Therapy May Be Essential

19:53 Addressing Potential Risks

28:20 How TRT Works & What to Expect

35:49 Looking at Estrogen and Progesterone 

37:23 LDL Medication and Low Testosterone

39:55 Addressing Thyroid Functionality

40:56 Honest Thoughts on Ozempic

50:28 Conclusion

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Tracy Gapin, MD, is a board-certified urologist, men’s health and performance expert. and founder of the Gapin Institute, a global leader in high performance medicine. He has over 20 years of experience focused on providing executives, entrepreneurs and athletes a personalized path to optimizing their health so they can have exceptional energy, laser-focused mind and a better body.



Text HEALTH to 26786 to receive an electronic copy of the High Performance Health Handbook for Men



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Hello everyone. I am delighted to let you all know about this episode of The Empowering Neurologist. We discuss fundamentally important new book, The Autoimmune Cure, by one of my dearest friends on the planet, New York Times bestselling author, Dr. Sara Gottfried.

In this interview, Dr. Gottfried enlightens us as to what is really underlying the vast array of autoimmune conditions. Yes, we do get into the weeds, but the information she provides is not just fascinating, but fully empowering as well. Prepare to be enlightened as she sheds light on how trauma can intricately rewire our bodies, ultimately becoming the catalyst for autoimmune diseases. With a prevalence that's skyrocketing globally, autoimmune conditions affect millions, yet the root cause often remains elusive.

Conventional medicine's approach often falls short in effectively diagnosing and treating autoimmune disorders. Many individuals grapple with baffling symptoms ranging from fatigue to brain fog, from aches and pains to anxiety, unaware that their immune system is the culprit behind their distress. Drawing from her wealth of experience in precision medicine, Dr. Gottfried has uncovered a compelling correlation between autoimmune disease and a history of trauma, a revelation that's shaping the future of autoimmune care.

But here's the exciting and empowering part—there's hope. Dr. Gottfried's revolutionary program outlined in he Autoimmune Cure offers a beacon of hope for those navigating the treacherous waters of autoimmune ailments. By addressing the root cause head-on and providing a comprehensive roadmap to reset the immune system, this program empowers individuals to reclaim their health and vitality.

So,  join us as we embark on a transformative journey towards autoimmune liberation. Whether you're grappling with autoimmune symptoms yourself or seeking to deepen your understanding of immune health, this podcast episode promises to be a beacon of insight and inspiration.



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0:00 Intro

2:15 We’re Looking at Autoimmune Wrong

8:04 Using Psychedelics for Healing Trauma 

12:58 Long Covid’s Impact on the Body

16:11 Thyroid Disruption

19:03 The Microbiome’s Impact on Immune Function

24:55 Symptoms Checklist & MS

30:26 Why Women have a Higher Risk 

37:19 Praise for Dr. Gottfried’s World

44:29 Conclusion

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Sara Szal Gottfried MD is a physician, researcher, author, and educator. She graduated from Harvard Medical School and MIT, and completed residency at UCSF, but is more likely to prescribe a CGM and personalized nutrition plan than the latest pharmaceutical. Dr. Gottfried is a global keynote speaker and the author of four New York Times bestselling books about hormones, nutrition, and health. Her latest book is called THE AUTOIMMUNE CURE (March 2024). She is Clinical Assistant Professor in Dept. of Integrative Medicine and Nutritional Sciences at Thomas Jefferson University, and Director of Precision Medicine at the Marcus Institute of Integrative Health. She takes care of executives and professional athletes. Her focus is at the interface of mental and physical health, N-of-1 trial design, personalized molecular profiling, use of wearables, and how to leverage these tools to improve health outcomes. Learn more at SaraGottfriedMD.com



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With so much discussion these days centered on metabolic health and issues like overweight, obesity, diabetes, and the downstream consequences of these health challenges, I think it's important to spend some time looking at what may be one of the pivotal  causes of metabolic disturbances, the consumption of fructose sugar.



As such, I reached out to Dr. Richard Johnson, a world’s authority on the role of fructose in human metabolism, to share with us his latest thoughts not only related to fructose, but also including the various types of sweeteners that are available and have become very popular. 



This discussion will take us into the world of GLP-1, a receptor that is stimulated by drugs like Ozempic. And no doubt, that is an area of discussion that is interesting for so many people.



We begin our discussion however with Dr. Johnson describing his recent trip to Dubai where he attended the COP 28 climate conference which, interestingly, includes his insights related to the threats posed by climate change on human metabolism.



Let me tell you a little bit more about Dr. Richard Johnson.He was formerly the chief of the Renal Division and Hypertension at the University of Colorado for nine years. He’s a physician, trained in internal medicine, infectious disease, and nephrology. Dr. Johnson is a widely cited NIH-funded scientist who has lectured in over 40 countries and has authored three books, The Sugar Fix, The Fat Switch, and the new Nature Wants Us to Be Fat. Rick has a special interest in the role of sugar and especially fructose and its byproduct uric acid in driving metabolic and kidney disorders. And most recently he has been exploring the biological properties of a unique sugar, allulose, a topic we discuss in great depth.



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0:00 Intro 

1:56 Climate Change and Rising Health Concerns 

12:53 Correlation of Uric Acid and Impulsivity

20:50 The Mechanics of Obesity as a Low Energy State

26:12 How Our Biology Supports Weight Gain

28:38 Impact of Sugar and Carbs on the Body

31:50 Should you avoid fruit?

33:09 What We should Be Doing

35:03 The World of Low Calorie Sugars

37:55 Disadvantages of Artificial Sweeteners 

41:32 Allulose: The Next Best Thing? 

54:19 How CGMs Will Change Your Perspective

55:10 The Role of Quercetin on Mitophagy 

58:20 Conclusion

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Dr. Johnson has performed medical research since the early 1980s and has been funded by the NIH since 1987. Most of  his research has focused on the pathogenesis of kidney diseases, but during the last 12 years his studies have also included studies of the pathogenesis of primary hypertension, insulin resistance and diabetes, diabetic nephropathy, and obesity. Much of his work has involved a combination of cell culture and animal models with a strong translational component, but he has also been involved in a number of clinical trials and epidemiology-based studies.

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Clearly, we've communicated a lot of information indicating that it's really fundamentally important for our health and ability to resist disease that we gain control over things like anxiety, lack of restorative sleep, lack of exercise, and certainly make other good choices like eating appropriately as well. These are powerful modulators of our metabolic health I have wide ranging implication not just as it relates to the brain, but our entire physiology. 



How exciting is that we live in the day and age of wearable devices. And, importantly, we now see the development of a wearable device that specifically allows us in a non pharmaceutical way to deal with anxiety, help us through the days it relates to our decision making ability, and even help us in the night as a relates to sleep, and it’s called Apollo. I thought it would be a great idea to interview the creator of this device, Dr. David Ravin.



Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses.



This is a very interesting podcast about a very interesting and clearly beneficial wearable device. I have found that using this device my heart rate variability has gone up dramatically, which is a good thing, and something I have been trying to accomplish for quite some time. This has huge implications for health. I hope you enjoy this information.



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0:00 Intro

3:09 Where It All Began - Searching for Stress Solutions

7:18 MDMA Therapy for PTSD

9:52 Why the Pushback on Psychedelic Therapy? 

12:20 New Wearable Tech that Simulates MDMA Benefits

19:56 Creating the Apollo 

24:53 Key Metric: Heart Rate Variability 

29:10 Dr. Perlmutter’s Success Story with the Apollo

34:32 Perceived vs Real Threat in Anxiety

36:53 Other Success Stories with Apollo

42:51 Solving the Problems of Sleep

50:04 Conclusion

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Dr. David Rabin, MD, PhD, a board-certified psychiatrist and neuroscientist, is the co-founder & chief medical officer at Apollo Neuroscience, the first scientifically-validated wearable system to improve heart rate variability, focus, relaxation, and access to meditative states by delivering gentle layered vibrations to the skin. In addition to his clinical psychiatry practice, Dr. Rabin is also the co-founder & executive director of The Board of Medicine, and a psychedelic clinical researcher currently evaluating the mechanism  of psychedelic-assisted psychotherapy in treatment-resistant mental illnesses. 



Socials:

Drdave.io

Apolloneuro.com

Boardofmedicine.org

Twitter: @daverabin



Instagram: @drdavidrabin



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One area that we spend a lot of time exploring focuses on the role of lifestyle choices as they relate to brain, health, functionality, and resistance to disease. I have to admit, over the years I have perhaps somewhat neglected a very important tool that offers up incredible utility as a relates to doing good

things for the brain, and that is art. With that in mind, I felt it would be a great idea to interview the authors of an exciting new book that explores this very topic entitled, Your Brain on Art by Susan Magsamen and Ivy Ross.

Your Brain on Art explores the vital role of arts in our lives, beyond mere entertainment. The book reveals a cultural evolution where arts emerge as powerful, accessible solutions for overall well-being. The authors present robust research highlighting the health benefits of art engagement. They illustrate how just 45 minutes of an art activity can significantly reduce stress hormones regardless of skill level, and regular artistic engagement could potentially extend life expectancy by a decade. The book delves into how music fosters cognitive abilities, the therapeutic effects of sound vibrations, the innovative use of virtual reality in therapy, and how interactive art experiences enhance memory and sensory engagement. It also discusses how art is being integrated into medical prescriptions for various health issues like loneliness and dementia.



Your Brain on Art serves as a gateway to understanding the intersection of arts, aesthetics, and wellness. It includes discussions with renowned figures like David Byrne, Renée Fleming, and E. O. Wilson, offering a comprehensive view of neuroaesthetics. This guide combines cutting-edge research, multidisciplinary expert insights, and inspirational stories, showcasing how arts significantly improve life quality.



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0:00 Intro 

3:07 How Susan & Ivy Began Studying Art

9:20 Why Art is Necessary for Humanity 

14:22 Your Brain on Art

18:50 How Observing Art Helps Us 

20:34 Reducing Amygdala Actions

22:16 The Healing Power of Sound and Vibration 

25:18 The Role of Aesthetics & Awe of Nature 

32:06 Poetry: the Oldest Art Form 

34:48 Treating Mental Illness with Art

40:06 Why Talent Doesn’t Matter

44:14 Creative Flow & Mindfulness

45:34 Theatre & Connecting to Our Emotions

51:04 Psychedelics for Healing

57:30 The Art of Food

1:00:51 Conclusion

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Susan Magsamen is the founder and executive director of the International Arts + Mind Lab (IAM Lab), Center for Applied Neuroaesthetics, a pioneering neuroaesthetics initiative from the Pedersen Brain Science Institute at Johns Hopkins University School of Medicine. Susan’s work focuses on how the arts and aesthetic experiences measurably change the brain, body and behavior and how this knowledge can be translated to inform health, wellbeing and learning programs in medicine, public health and education. 

 Magsamen is also the co-author of the New York Times Bestseller, Your Brain on Art: How the Arts Transform Us written for the general public. 



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Ivy Ross is the Vice President of Design for the Hardware organization at Google. Over the past six years, she and her team have launched 50+ products winning over 240 global design awards. This collection of hardware established a new Google design aesthetic that is tactile, colorful, and bold.

Most recently, Ivy co-authored with SusanMagsamen Your Brain on Art: How the ArtsTransform Us.



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