Medscape InDiscussion: COVID-19 Medscape

Drs Matteo Bassetti and Cristina Mussini discuss the future of COVID-19 and sustainable approaches to living with an endemic.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989643). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.
Resources
Barriers to and Strategies to Address COVID-19 Testing Hesitancy: A Rapid Scoping Review https://pubmed.ncbi.nlm.nih.gov/35422031/
Factors Associated With Mortality Among Elderly People in the COVID-19 Pandemic (SARS-CoV-2): A Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/34360301/
COVID-19 and Lung Pathologies https://pubmed.ncbi.nlm.nih.gov/34333882/
Editorial: A Rapid Global Increase in COVID-19 Is Due to the Emergence of the EG.5 (Eris) Subvariant of Omicron SARS-CoV-2 https://pubmed.ncbi.nlm.nih.gov/37654205/
Covid-19: Scientists Sound Alarm Over New BA.2.86 "Pirola" Variant https://pubmed.ncbi.nlm.nih.gov/37620014/
Recommendations for the Management of Drug-Drug Interactions Between the COVID-19 Antiviral Nirmatrelvir/Ritonavir (Paxlovid) and Comedications https://pubmed.ncbi.nlm.nih.gov/35567754/
Early Remdesivir to Prevent Progression to Severe Covid-19 in Outpatients https://pubmed.ncbi.nlm.nih.gov/34937145/
Characterization of an EG.5.1 Clinical Isolate in Vitro and in Vivo https://www.biorxiv.org/content/10.1101/2023.08.31.555819v1
Omicron: The Pandemic Propagator and Lockdown Instigator - What Can Be Learnt From South Africa and Such Discoveries in Future https://pubmed.ncbi.nlm.nih.gov/35070471/
Systematic Lung Ultrasound in Omicron-Type vs. Wild-Type COVID-19 https://pubmed.ncbi.nlm.nih.gov/36288539/
Sospensione di Utilizzo del Medicinale Lagevrio® (Molnupiravir) https://www.aifa.gov.it/-/sospensione_utilizzo_lagevrio_molnupiravir

Drs Matteo Bassetti and Giuseppe Remuzzi discuss the future of COVID prevention, vaccination priorities, new variants, and home-based healthcare in the coming winter.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989642). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.
Resources
Coronavirus Disease 2019 (COVID-19) Treatment & Management https://emedicine.medscape.com/article/2500114-treatment
The Lost Days That Made Bergamo a Coronavirus Tragedy https://www.nytimes.com/2020/11/29/world/europe/coronavirus-bergamo-italy.html
ACE2 Angiotensin Converting Enzyme https://www.ncbi.nlm.nih.gov/gene/59272
Renin Angiotensin System https://www.ncbi.nlm.nih.gov/books/NBK470410/
A Rampage Through the Body https://www.science.org/content/article/how-does-coronavirus-kill-clinicians-trace-ferocious-rampage-through-body-brain-toes
Avian Influenza (Bird Flu) https://emedicine.medscape.com/article/2500029-overview
WHO EG.5 Initial Risk Evaluation, 9 August 2023 https://www.who.int/docs/default-source/coronaviruse/09082023eg.5_ire_final.pdf
Updated Working Definitions and Primary Actions for SARS-CoV-2 Variants https://www.who.int/publications/m/item/updated-working-definitions-and-primary-actions-for--sars-cov-2-variants
Risk Assessment Summary for SARS-CoV-2 Sublineage BA.2.86 https://www.cdc.gov/respiratory-viruses/whats-new/covid-19-variant.html#

Drs Matteo Bassetti and Romain Sonneville discuss identifying long COVID in patients and how to discuss post-COVID syndrome with patients and other healthcare providers.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989641). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.
Resources
Coronavirus Disease 2019 (COVID-19) Treatment & Management https://emedicine.medscape.com/article/2500114-treatment
Long Coronavirus 2019 (COVID-19) https://emedicine.medscape.com/article/2500143-overview
Post-COVID Syndrome: An Insight on Its Pathogenesis https://pubmed.ncbi.nlm.nih.gov/34066007/
Acute Neurologic Complications of COVID-19 and Postacute Sequelae of COVID-19 https://pubmed.ncbi.nlm.nih.gov/35667743/
Infection Mechanism of SARS-COV-2 and Its Implication on the Nervous System https://pubmed.ncbi.nlm.nih.gov/33584720/
Cardiac Manifestations of Coronavirus (COVID-19) https://www.ncbi.nlm.nih.gov/books/NBK556152/
Efficacy of First Dose of COVID-19 Vaccine Versus No Vaccination on Symptoms of Patients With Long COVID: Target Trial Emulation Based on ComPaRe E-cohort https://pubmed.ncbi.nlm.nih.gov/36910458/
Clinical Characteristics and Outcomes in Elderly With Coronavirus Disease 2019 in Beijing, China: A Retrospective Cohort Study https://pubmed.ncbi.nlm.nih.gov/33040272/
Management and Treatment of Long COVID Symptoms in General Practices: An Online-based Survey https://pubmed.ncbi.nlm.nih.gov/36176520/
Chronic Fatigue Syndrome (Myalgic Encephalomyelitis) https://emedicine.medscape.com/article/235980-overview

Drs Matteo Bassetti and Tobias Welte discuss highlights in the treatment of patients with COVID-19, including a discussion of antivirals, corticosteroids, monoclonal antibodies, and what lies ahead for future treatment options.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989640). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.
Resources
Coronavirus Disease 2019 (COVID-19) Treatment & Management https://emedicine.medscape.com/article/2500114-treatment
Anti-CD20 Monoclonal Antibody TL011 https://www.cancer.gov/publications/dictionaries/cancer-drug/def/anti-cd20-monoclonal-antibody-tl011
Rituximab (Rx) https://reference.medscape.com/drug/rituxan-truxima-rituximab-342243
Coronavirus Disease 2019 (COVID-19) https://emedicine.medscape.com/article/2500114-overview
SARS-CoV-2 Variants https://www.idsociety.org/covid-19-real-time-learning-network/emerging-variants/emerging-covid-19-variants/
Not Just Antibodies: B Cells and T Cells Mediate Immunity to COVID-19 https://pubmed.ncbi.nlm.nih.gov/32839569/
Antivirals, Including Antibody Products https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/
Hydrocortisone in Severe Community-acquired Pneumonia https://pubmed.ncbi.nlm.nih.gov/36942789/
Molnupiravir (Investigational) https://reference.medscape.com/drug/lagevrio-molnupiravir-4000252
Nirmatrelvir/ritonavir (Rx) https://reference.medscape.com/drug/paxlovid-nirmatrelvir-ritonavir-4000259
Remdesivir (Rx) https://reference.medscape.com/drug/veklury-remdesivir-4000090
Anti-SARS-CoV-2 Monoclonal Antibodies https://www.covid19treatmentguidelines.nih.gov/therapies/antivirals-including-antibody-products/anti-sars-cov-2-monoclonal-antibodies/
Considerations for SARS-CoV-2 Antigen Testing for Healthcare Providers Testing Individuals in the Community https://www.cdc.gov/coronavirus/2019-ncov/lab/resources/antigen-tests-guidelines.html

Drs Matteo Bassetti and Oliver Cornely advise to "use the best treatments first" in discussing how to manage COVID-19 in patients who are immunocompromised.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989639). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.
Resources
VACCELERATE Network https://vaccelerate.eu/
Duration of Protection From Pneumonia After Pneumococcal Vaccination in Hemodialysis Patients (DOPPIO) https://clinicaltrials.gov/ct2/show/NCT03350425
Remdesivir Prescribing Information https://www.gilead.com/-/media/files/pdfs/medicines/covid-19/veklury/veklury_pi.pdf
Paxlovid Dosing and Prescribing Reference Guide https://www.paxlovidhcp.com/files/PP-PAX-USA-0296_Dosing_Prescribing_Reference_Guide_L35.pdf
Molnupiravir and Nirmatrelvir-Ritonavir: Oral Coronavirus Disease 2019 Antiviral Drugs https://pubmed.ncbi.nlm.nih.gov/35245942/
Influenza Vaccination Uptake in the General Italian Population During the 2020-2021 Flu Season: Data From the EPICOVID-19 Online Web-Based Survey https://pubmed.ncbi.nlm.nih.gov/35214751/
COVID-19 Infection in Adult Patients With Hematological Malignancies: A European Hematology Association Survey (EPICOVIDEHA) https://pubmed.ncbi.nlm.nih.gov/34649563/
Clinical Characteristics and Risk Factors Associated With COVID-19 Severity in Patients With Haematological Malignancies in Italy: A Retrospective, Multicentre, Cohort Study https://pubmed.ncbi.nlm.nih.gov/32798473/

Drs Matteo Bassetti and Antoni Torres explore the early response to patients with severe COVID-19 and how treatment options have progressed since 2020.
Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/989637). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for healthcare professionals.
Resources
Coronavirus Disease 2019 (COVID-19) Treatment & Management https://emedicine.medscape.com/article/2500114-treatment
Dexamethasone in Hospitalized Patients With Covid-19 https://pubmed.ncbi.nlm.nih.gov/32678530/
Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19: A Meta-analysis https://pubmed.ncbi.nlm.nih.gov/32876694/
Predictive Factors of Six-week Mortality in Critically Ill Patients With SARS-CoV-2: A Multicenter Prospective Study https://pubmed.ncbi.nlm.nih.gov/35461665/
Procalcitonin (PCT) https://emedicine.medscape.com/article/2096589-overview
C-reactive Protein https://emedicine.medscape.com/article/2086909-overview
Ferritin https://emedicine.medscape.com/article/2085454-overview
D-dimer https://emedicine.medscape.com/article/2085111-overview
Performance of Pneumonia Severity Index and CURB-65 in Predicting 30-day Mortality in Patients With COVID-19 https://pubmed.ncbi.nlm.nih.gov/32553714/
Understanding the Role of ACE-2 Receptor in Pathogenesis of COVID-19 Disease: A Potential Approach for Therapeutic Intervention https://pubmed.ncbi.nlm.nih.gov/34176080/
Acute Respiratory Distress Syndrome (ARDS) https://emedicine.medscape.com/article/165139-overview
Driving Pressure, Mediation Analysis, and Spontaneous Breathing https://www.medscape.com/viewarticle/848731
Effect of Viral Storm in Patients Admitted to Intensive Care Units With Severe COVID-19 in Spain: A Multicentre, Prospective, Cohort Study https://pubmed.ncbi.nlm.nih.gov/37116517/
A Living WHO Guideline on Drugs for Covid-19 https://pubmed.ncbi.nlm.nih.gov/32887691/
Therapeutic Management of Hospitalized Adults With COVID-19 https://www.covid19treatmentguidelines.nih.gov/management/clinical-management-of-adults/hospitalized-adults--therapeutic-management/
Remdesivir and Survival Outcomes in Critically Ill Patients With COVID-19: A Multicentre Observational Cohort Study https://pubmed.ncbi.nlm.nih.gov/36596315/
Triple Combination Therapy With Two Antivirals and Monoclonal Antibodies for Persistent or Relapsed SARS-CoV-2 Infection in Immunocompromised Patients https://pubmed.ncbi.nlm.nih.gov/36976301/
COVID-19 Treatment: Investigational Drugs and Other Therapies https://emedicine.medscape.com/article/2500116-overview#a3