The Scientist’s LabTalk tslabtalk

Lauren Drouin shares how personal connections and scientific curiosities drive her work on gene therapy viral vectors.

Researchers commonly employ lentiviruses to modify cells genetically. However, they must overcome several challenges when using these viruses in the laboratory or clinic. In this episode, Charlene Lancaster from The Scientist’s Creative Services Team spoke with Filippo Rossignoli, instructor in neurosurgery at the Center for Stem Cell and Translational Immunotherapy at Brigham and Women's Hospital and Harvard Medical School, about using lentiviruses to engineer cell therapies and the troubleshooting process he undertook to optimize viral production and infection.
 
More on this topic: https://www.the-scientist.com/infographics/viral-vector-platforms-for-gene-therapy-70941
 
LabTalk is a special edition podcast produced by The Scientist's Creative Services Team, where we explore topics at the leading edge of innovative research. This month’s episode is sponsored by Mirus Bio.

Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts about their experiences designing and implementing assays and protocols for future molecular diagnostics.
In this episode, Deanna MacNeil from The Scientist’s Creative Services Team spoke with Gregory Tsongalis, medical director for the Center for Clinical Genomics and Advanced Technology at Dartmouth Health, about the benefits of PCR-based DNA testing for HPV screening.
 
Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers are accelerating life sciences research, solving complex analytical challenges, and improving clinical research workflows, Thermo Fisher Scientific is here to support them.

Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts about their experiences designing and implementing assays and protocols for future molecular diagnostics.
 
In this episode, Deanna MacNeil from The Scientist’s Creative Services Team spoke with Ming-Sound Tsao, a senior scientist and clinician at Princess Margaret Cancer Centre, about considerations and variables for choosing appropriate assays in precision lung cancer treatment, including biomarkers, internal controls, test sensitivity, and specificity.
 
Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers are accelerating life sciences research, solving complex analytical challenges, and improving clinical research workflows, Thermo Fisher Scientific is here to support them.

Scientists commonly use qPCR applications in molecular diagnostics to detect pathogens, assess viral loads, or uncover mutations. While the qPCR assay itself may seem straightforward, other aspects such as data collection and security, and following regulatory guidelines, present challenges.
In this episode, Gloria Lam, the associate director of qPCR software for Thermo Fisher Scientific, discusses concerns surrounding molecular diagnostic data collection, analysis, cybersecurity, and more.
 
Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers are accelerating life sciences research, solving complex analytical challenges, and improving clinical research workflows, Thermo Fisher Scientific is here to support them.
Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts about their experiences designing and implementing assays and protocols for future molecular diagnostics.

Welcome to Molecular Diagnostics: An Eye Toward the Future, a special edition podcast series produced by The Scientist’s Creative Services Team. This series is brought to you by Thermo Fisher Scientific, a world leader in serving science. Their mission is to enable customers to make the world healthier, cleaner, and safer. Whether their customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies, or increasing productivity in their laboratories, Thermo Fisher Scientific is here to support them.
Scientists continuously develop new assays to fill unmet diagnostic needs. While methods such as quantitative PCR have emerged as essential tools in molecular diagnostics, scientists developing and administering these assays still must overcome technical challenges. In this podcast series, The Scientist’s Creative Services Team talks to experts in assay development about their experiences designing and implementing assays and protocols for future molecular diagnostics.
In this episode, Niki Spahich from The Scientist’s Creative Services Team spoke with Anne Wyllie, a research scientist in epidemiology at the Yale School of Public Health, about the development of SalivaDirect—a quantitative PCR protocol, authorized by the FDA under an emergency use authorization, that detects SARS-CoV-2 in saliva.