162 episodes

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

Dr. Kara Fitzgerald | New Frontiers in Functional Medicine, Longevity, Epigenetics Dr. Kara Fitzgerald

    • Health & Fitness

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF

Copyright © 2023 by KF Education and Consulting, LLC
All Rights Reserved

    Dr. Barry Sears (of Zone Diet Fame) on Lifetime Metabolic Health and Sourcing Omega-3s

    Dr. Barry Sears (of Zone Diet Fame) on Lifetime Metabolic Health and Sourcing Omega-3s

    In this episode, I'm excited to welcome Dr. Barry Sears, the renowned creator of the Zone Diet and a pillar in our field. Dr. Sears has not only authored bestsellers but has also made incredibly important contributions to clinical practice which we still rely on today: He is, for instance, the scientist who put the use of the AA:EPA ratio on the map. Dr. Sears provides elegant and accessible explanations of the unassailable importance of diet in addressing inflammation, metabolic health, chronic disease, and longevity, and the role that fatty acids play in that milieu. And while he and I might not agree that polyphenols need to be absorbed intact for benefit - there's plenty of evidence that their postbiotic products are very important players, especially in their interactions with the epigenome - his concerns about the chemical structure of highly concentrated fish oil supplements (with the potential for isomerization, as he argues) has opened my eyes and is important, without doubt. I think the jury is still out as to whether there is a negative influence of isomerization in highly concentrated EPA and DHA, but it's worthy of further investigation and (importantly) is another factor in the argument for a whole-food approach. - DrKF

    Check out the show notes at https://www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

    Guest information
    Dr. Barry Sears, President, Inflammation Research Foundation and CEO of Zone Labs.Inc.
    bsears@drsears.com

    http://www.drsears.com/
    http://www.zoneliving.com/
    http://www.inflammationresearchfoundation.org/

    Thank you to our Sponsors
    Diamond
    Rupa Health - https://tinyurl.com/yc26f6sj
    Biotics Research - https://www.bioticsresearch.com/
    Integrative Therapeutics - https://tinyurl.com/47sfktzb

    Gold
    OneSkin - https://tinyurl.com/ycxvz5we
    Mira - https://tinyurl.com/3pj4t338
    TimeLine Nutrition - https://tinyurl.com/4bsdfczz

    Midroll
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    Show Notes
    Dietary Control of Inflammation and Resolution - https://tinyurl.com/vadkjzf7
    The STRENGTH trial - https://tinyurl.com/282cz27m
    OMEMI Trial - https://pubmed.ncbi.nlm.nih.gov/33191772/
    REDUCE-IT Study - https://clinicaltrials.gov/study/NCT01492361
    ASCEND Study - https://ascend.medsci.ox.ac.uk
    VITAL Study - https://www.vitalstudy.org/
    Longitudinal Study - Multi-omics Biological Age Estimation and Its Correlation with Wellness and Disease Phenotypes - https://tinyurl.com/2p85yx5f

    • 1 hr 8 min
    Unraveling PCOS and Fertility: Debunking Common Misconceptions with Dr. Tara Harding

    Unraveling PCOS and Fertility: Debunking Common Misconceptions with Dr. Tara Harding

    Gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s personal and professional journey is a beacon of hope and empowerment, underscoring the significance of comprehensive care in women’s health. Prepare to be inspired by her dedication to revolutionizing fertility care and advocating for patient empowerment. ~DrKF

    Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

    • 1 hr 1 min
    AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

    AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

    Fellow clinicians, get ready for a mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. And being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions). It’s heady stuff, but amazingly, it is where we are headed today.

    Dr. Price illustrates the incredible potential this technology brings for personalized evidence-based medicine, such as tailoring interventions based on microbial markers or targeting specific lifestyle changes for Alzheimer's prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my conversation with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same. ~DrKF

    Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

    • 1 hr 33 min
    Decoding Aging: The Science Of Cellular Rejuventation With Dr. Vittorio Sebastiano

    Decoding Aging: The Science Of Cellular Rejuventation With Dr. Vittorio Sebastiano

    It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth - that is, radically reverse our biological aging process to a younger time point without losing cellular identity.

    In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials.

    Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine.

    In this podcast - which is actually two-in-one because I continued the conversation with him on a second date - you’ll hear about the remarkable work they’re undertaking at his lab. For example: They’ve created a biological clock that encompasses the whole genome consisting of millions and millions of CpG sites. They are able to clearly demonstrate the reversal of bioage using their methodology - a cocktail of Yamanaka factors plus, with clear time limits - which changes the epigenome first, and in so doing influences all of the hallmarks of aging. Teaser: they’ve identified one intervention routinely used in clinical practice that influences their bio age clock in the same way that their cocktail does. What is it? I was riveted with this conversation, as I am sure you’ll be. Leave a review if you like it, and - Yes - let me know what you think. I know this will prompt deep questions for you, as it did for me. ~DrKF


    Check out the show notes at www.drkarafitzgerald.com/fxmed-podcast/ for all the relevant links and resources.

    • 1 hr 49 min
    Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond

    Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond

    Aging itself stands as the paramount driver of disease. As functional practitioners, the question arises: How can we assess biological age to make precise corrections that foster both healthspan and lifespan? Enter the era of omics, where metabolomics emerges as an exceptional tool with transformative potential. I'm thrilled to welcome back Dr. Betsy Redmond, longtime friend and the senior education specialist at Diagnostic Solutions Laboratory, to New Frontiers to lead us on this discussion.Together, we'll take a deep dive into specific metabolites and pathways intricately linked to aging, mood, inflammation, and gut health and you’ll hear about equol, a rising star on the postbiotic scene. We'll even unravel some surprising insights from my own test results!

    Be sure to grab a copy of the Sample Report and pull up a seat for this fascinating discussion packed with valuable takeaways for yourself and your practice. ~DrKF

    You'll find it all at www.drkarafitzgerald.com/fxmed-podcast/

    • 59 min
    Burnout in Healthcare: Causes, Consequences, and Solutions with Dr. Jonathan Prousky

    Burnout in Healthcare: Causes, Consequences, and Solutions with Dr. Jonathan Prousky

    Working in healthcare brings a unique set of challenges and stressors. But the truth is that any of us can get to burnout through challenging circumstances of work or study. And the consequences can range from severe to devastating. Burnout still hasn't been fully understood or recognized by the medical profession and other industries - there is still no official diagnosis classification. Along with other mental health disorders, it is often still (wrongly) stigmatized and can even sometimes be seen as a "badge of honor," much to our detriment. Dr. Jonathan Prousky, Chief Naturopathic Medical Officer at the Canadian College of Naturopathic Medicine, joins me once again in this New Frontiers episode to explore the state of burnout in healthcare workers and beyond. Whether you work in our field or not, I guarantee you'll find it insightful. Together we explore the challenges we all face, and practical solutions to help you maintain your own health and well-being. As always, please feel free to share, comment, and rate - and let us know your thoughts on this important topic. ~DrKF

    Do You Think You Might Be Suffering From Burnout? Take this quiz to find out and learn how to prevent or reduce burnout naturally. www.drkarafitgerald.com/burnout

    • 1 hr 6 min

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