The Functional Breeding Podcast The Functional Dog Collaborative

Last episode I talked with Dr. Dan O'Neill, a veterinary epidemiologist who studies canine disorders that have an inherited component - what the rest of us might call "genetic diseases." During that interview he mentioned that he didn't think disorder testing - what most of us call health testing - has been workinig to improve canine health. I cut that section because I felt we needed to go into a lot more detail on it to understand what he meant by that, since I knew he didn't mean we should entirely stop health testing - I mean disorder testing. So here is the followup interview. I want to emphasize that he isn't saying disorder testing shouldn't be done as an aid to choosing how to breed dogs. He IS saying that the way we approach choosing and interpreting tests could use a revamp. I hope you enjoy this conversation as much as I did!

Dan O'Neill, MVB, PhD, FRCVS is a veterinary epidemiologist who studies canine disorders that have an inherited component - what the rest of us might call "genetic diseases." He is the author of more than 95 papers, mostly on the prevalence and risk factors of disorders in dogs based on data drawn from VetCompass, the large scale veterinary database and research tool that he co-leads. Dan was awarded the Kennel Club Charitable Trust "International Canine Health Award" in 2021, and is passionate both about the health of purebred dogs and about saving breeds.

Danika Bannasch, DVM, PhD returns to the podcast to talk about the Dalmatian Outcross Project. Danika's laboratory found the genetic mutation that was targeted in this outcross, and she had a front row seat to the project's path to acceptance by the AKC and the Dalmatian Club of America. She is also herself a past breeder of Dalmatians. Danika walks us through the genetic, social, and practical implications of high uric acid in Dalmatians, why the outcross was necessary, how it worked, and which populations with different mutations could be helped today by a similar approach (spoiler - one of them is the population of dogs in breeds with high frequency of the chondrodystrophy mutation that we discussed in the previous episode).

Danika Bannasch, DVM, PhD is the owner of Pint, the famous UC Davis football tee retrieving dog. She also happens to run a genetics lab, also at UC Davis, where she studies the genetics of inherited diseases in dogs and other animals. She is known for her work associating genetic variants with a variety of traits including coat color and skull shape. On this episode we're talking about a genetic mutation that she discovered - known to genetic testing companies as CDDY - for a trait she feels passionately about, chondrodystrophy. Most of the dog world knows this mutation as "that risk gene that makes your dog more likely to get IVDD," but in this episode, Danika talks us through the difference between disc herniation and IVDD (intervertebral disc disease), noting that all dogs with CDDY have IVDD, and therefore disc degeneration, whether or not they actually herniate. I hope you learn as much from this discussion as I did.
 
Find this episode's transcript here.

Lisa Gunter, PhD, CBCC-KA is an Assistant Professor at Virginia Tech in the School of Animal Sciences and directs the Laboratory for Animal Behavior and Welfare. Lisa’s research explores the behavior and welfare of companion animals, specifically our interactions with them, as it relates to animal sheltering, behavioral issues, and training. Lisa combines a love of research with hands-on dog training skills. I wanted to have someone from the shelter world on the podcast because, depending on what you mean by "source," shelters are a source of dogs. Lisa and I talked about how shelters can best help dogs cope with the shelter experience and what the future of sheltering might look like.
For those interested in the Applied Animal Behavior and Welfare online MS program at Virginia Tech, where Lisa and Jessica both teach, check it out at https://www.cals.vt.edu/academic-programs/online/omals-program-virginia-tech.html.

Carolyn Kelly is a registered nurse with over 30 years of experience in human health including in labor and delivery, and in mental health. She also holds a Masters Degree in Nursing Leadership. She runs a mixed breed companion dog program, Old Mission Retrievers. Erica Pytlovany, KPA CTP, is an experienced behavioral consultant at WOOFS! Dog Training Center in Virginia. She runs the Boson Dog Project, a mixed breed companion dog program, with her wife, Laura Sharkey. I got together with Carolyn and Erica to talk about what companion personalities look like in dogs and why they focus their breeding programs on achieving them.