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Known for its synergistic approach to biomedical science, the Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH). With 1,100 Principal Investigators and more than 4,000 Postdoctoral Fellows conducting basic, translational, and clinical research, the IRP is the largest biomedical research institution on earth. Its mission is science in pursuit of fundamental knowledge about living systems and the application of that knowledge to extend healthy life and reduce illness and disability throughout the world. In the IRP's new podcast, Speaking of Science, you will meet many of the federal researchers working to change lives by advancing all aspects of biomedicine.

Speaking of Science The National Institutes of Health’s (NIH) Intramural Research Program (IR

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Known for its synergistic approach to biomedical science, the Intramural Research Program (IRP) is the internal research program of the National Institutes of Health (NIH). With 1,100 Principal Investigators and more than 4,000 Postdoctoral Fellows conducting basic, translational, and clinical research, the IRP is the largest biomedical research institution on earth. Its mission is science in pursuit of fundamental knowledge about living systems and the application of that knowledge to extend healthy life and reduce illness and disability throughout the world. In the IRP's new podcast, Speaking of Science, you will meet many of the federal researchers working to change lives by advancing all aspects of biomedicine.

    Dr. Jerry Yakel — Acetylcholine Receptors and Neurological Disease

    Dr. Jerry Yakel — Acetylcholine Receptors and Neurological Disease

    Serious problems can arise when communication between neurons gets scrambled. Dr. Jerry Yakel is a neurobiologist studying acetylcholine receptors, which allow neurons to turn signals transmitted using the chemical acetylcholine into electrical messages. Learning about these receptors could produce insights into brain diseases like Alzheimer's, Parkinson's, and epilepsy. Dr. Yakel is a Senior Investigator at the National Institute of Environmental Health Sciences (NIEHS). https://irp.nih.gov/pi/jerrel-yakel

    • 52 分鐘
    Dr. Armin Raznahan — Genes, Brain Structure, and Neuropsychiatric Disorders

    Dr. Armin Raznahan — Genes, Brain Structure, and Neuropsychiatric Disorders

    Neuropsychiatric illnesses like Tourette syndrome and schizophrenia have clear effects on behavior, but much less is known about how they relate to changes in the brain. Dr. Armin Raznahan is a child psychiatrist studying how the brains of children and adolescents with such conditions differ from those of healthy individuals. Dr. Raznahan is a Lasker Clinical Research Scholar at the National Institute of Mental Health (NIMH). https://irp.nih.gov/pi/armin-raznahan

    • 58 分鐘
    Dr. Catharine Bosio — The Weird and Deadly Francisella Tularensis Bacterium

    Dr. Catharine Bosio — The Weird and Deadly Francisella Tularensis Bacterium

    Our houses, workplaces, and even the air we breathe are teeming with microbes that can cause severe illness. Dr. Catharine Bosio is an immunologist studying how airborne pathogens infect and alter cells in the lungs. Her work focuses in particular on a bacterium called Francisella tularensis, which causes a life-threatening disease called tularemia. Dr. Bosio is a Senior Investigator at the National Institute of Allergy and Infectious Diseases (NIAID). https://irp.nih.gov/pi/catharine-bosio

    • 50 分鐘
    Dr. Cynthia Dunbar — Stem Cell Therapies for Blood and Immune System Diseases

    Dr. Cynthia Dunbar — Stem Cell Therapies for Blood and Immune System Diseases

    Our blood is made up of a diverse array of different cells, all of which originate from the same source: the ‘hematopoietic’ stem cells in our bone marrow. Dr. Cynthia Dunbar's research into the transplantation and manipulation of hematopoietic stem cells could lead to treatments for a wide variety of diseases caused by a lack of properly functioning blood cells. Dr. Dunbar is a Principal Investigator at the National Heart, Lung, and Blood Institute (NHLBI). https://irp.nih.gov/pi/cynthia-dunbar

    • 1 小時 4 分鐘
    Drs. Ira Pastan and Michael Gottesman — Cancer Immunotoxins and Multidrug Resistance

    Drs. Ira Pastan and Michael Gottesman — Cancer Immunotoxins and Multidrug Resistance

    Dr. Ira Pastan is an NIH Distinguished Investigator (https://irp.nih.gov/pi/ira-pastan) who created a new type of cancer drug, a recombinant immunotoxin, that was approved by the FDA in September 2018 for certain adults with hairy cell leukemia. He is joined by guest host Dr. Michael Gottesman, who, as the NIH Deputy Director for Intramural Research (https://irp.nih.gov/pi/michael-gottesman), leads the scientists and clinicians working within the IRP — while also investigating drug resistance in cancer.

    • 1 小時
    Dr. Dori Germolec — Environmental Chemicals Versus the Immune System

    Dr. Dori Germolec — Environmental Chemicals Versus the Immune System

    Dori Germolec, Ph.D., is a biologist studying how the chemicals in our environment affect the immune system, including toxic or carcinogenic effects of molds and dietary supplements. From bisphenols and flame retardants to arsenic in the drinking water, we are all exposed to a mixture of compounds on a daily basis. Dr. Germolec leads the Systems Toxicology Group of the NIH's National Institute of Environmental Health Sciences (NIEHS). https://www.niehs.nih.gov/research/atniehs/labs/tob/systems/index.cfm

    • 54 分鐘

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