#51: Heat Shock Proteins | Antibiotic Resistance | DHT Safety | Energy and Aging with Ray Peat, PhD Generative Energy Podcast

00:00 - Start

01:10 - Ray's new newsletter

05:05 - Le Chatelier's principle, Lamarckian fish, Barbara McClintock

09:18 - Gilbert Ling, ATP "the queen of cardinal adsorbents," phase transitions, coacervates, rigor mortis

13:51 - "The role of ATP is not limited to the contraction cycle. It dominates the physical state of muscle even in rest, keeping it soft and pliable... rigor mortis is but a lack of ATP..." Albert Szent-Györgyi

14:43 - Does the activation of the heat shock proteins (HSPs) precede cell division?

16:02 - Niacinamide and solubility, energy loss, DNA repair

19:09 - What about gelatin?

20:85 - Estrogen activates HSPs, redox balance, progesterone inhibits HSPs, water economy

23:15 - Should we activate the HSPs?

25:12 - Will the activation of the HSPs leave a scar?

27:06 - "Energy deprivation stabilizing proteins"

29:37 - Metallic taste in the mouth, lipid peroxidation

30:20 - "Estrogen, hyperventilation, lactate, etc., increase serotonin, and I think it’s serotonin that directly increases PTH, and then PTH increases NO." Ray Peat (2017)

33:30 - The living cell is more susceptible in the fatigued state

38:23 - HSP inhibitors: tetracycline, progesterone, methylene blue, etc.

38:58 - Is PTH a "newer" part of the system?

40:25 - Is RAAS more ancient than the HPA?

40:54 - Ray Peat's newsletter, Progest-E from Kenogen, Ray's history with progesterone

45:24 - Why can progesterone fill-in for the adrenals but pregnenolone cannot?

48:14 - Are pregnenolone and progesterone "true" hormones?

49:25 - If someone has a sensitive stomach -- how can they take progest-E?

50:14 - Ray's thoughts on using DHT and testosterone, gynecomastia, finasteride, governing principles of health

55:40 - Is DHT always "safer" than testosterone? Ray's thoughts on TRT

58:34 - What does Ray think of as a "max dose" of aspirin at one time?

01:00:04 - What happens to the agaratine in mushrooms? Does the mushroom water contain agaratine?

01:01:26 - How to distinguish between a fungal and bacterial infection?

01:07:40 - Does Ray prefer pure olive oil over coconut oil for the carrot salad and mushrooms? 1/2 a teaspoon provides a trace of PUFA

01:08:39 - Are fungal infections rarer than bacterial infections?

01:09:20 - H.pylori infection -- how to treat? Thoughts on dosing antibiotics

01:12:41 - The two-week time frame for antibiotic use scientific?

01:13:45 - Is antibiotic resistance important for the individual?

01:14:28 - Does antibiotic use cause a fungal overgrowth?

01:16:05 - Tetracyclines as antifungals? Inflammation predisposes to infection, feeling "uncomfortable" on minocycline

01:19:16 - Danny's experience on minocycline

01:21:46 - Question: why would a virus want to invade a cell?

01:29:28 - Viruses and weakened organisms

01:30:57 - Do viral pandemics exist?

01:36:02 - “...That is, if one pursues any ‘physical’ illness far enough and deep enough, one will find inevitably intrapsychic, intrapersonal, and social variables that are also involved as determinants.” Maslow (1993)

01:38:08 - What's the factor in the environment that's leading to frailty in young people?

01:40:42 - If a group has a problematic "death culture" holy book -- how can a functioning society be maintained?

01:44:54 - Could a holistic view of science be a foundation for a functional society?

01:45:51 - What is the long-term "artificial" struggle between humans?

01:47:10 - Does authoritarianism have anything to do with nature?
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