22 min

8 | Layers of the Gut: Anatomy of Leaky Gut Mind the Roots

    • Alternative Health

In pursuit of mechanisms and evidence-based approaches, gut health has been revealed as a critical cornerstone of neurological health.

In this episode, we're going into detail on what the gut layers are. I hope this video will help someone else who's trying to understand how the gut works for purposes of biohacking with functional medicine, nutrition, supplements, etc. For any intervention, is there evidence of a relationship, and is there data that it worked in other humans?

We talk about:


what the gut mucus is made out of


elements of the gut barrier - the many ways the body keeps microbes and partially digested food away


kinds of intestinal epithelial cells (Goblet cells, Paneth cells, M cells, etc.) and their functions


types of gut associated lymphoid tissue (GALT) and their distinctions - lamina propria, Peyer's patches, lymph nodes


the enteric nervous system and enteroendocrine cells


different types of CD4+ T cells: Th1, Th2, Th17, and Treg, what they respond to, and their major outputs


the mechanism of nutrient absorption


the mechanism of leaky gut (paracellular transport through tight junctions)



Here's the video: https://youtu.be/sIn_VxH6zDA

Transcript of the video, for those who are pressed for time: https://www.brainforest.org/post/leaky-gut-anatomy

I hope this helps someone understand their gut a little better on the path to health. Stay tuned for our next podcast on the relationship between leaky gut and aging. Share this resource with others who are studying gut anatomy on the path to health!

In pursuit of mechanisms and evidence-based approaches, gut health has been revealed as a critical cornerstone of neurological health.

In this episode, we're going into detail on what the gut layers are. I hope this video will help someone else who's trying to understand how the gut works for purposes of biohacking with functional medicine, nutrition, supplements, etc. For any intervention, is there evidence of a relationship, and is there data that it worked in other humans?

We talk about:


what the gut mucus is made out of


elements of the gut barrier - the many ways the body keeps microbes and partially digested food away


kinds of intestinal epithelial cells (Goblet cells, Paneth cells, M cells, etc.) and their functions


types of gut associated lymphoid tissue (GALT) and their distinctions - lamina propria, Peyer's patches, lymph nodes


the enteric nervous system and enteroendocrine cells


different types of CD4+ T cells: Th1, Th2, Th17, and Treg, what they respond to, and their major outputs


the mechanism of nutrient absorption


the mechanism of leaky gut (paracellular transport through tight junctions)



Here's the video: https://youtu.be/sIn_VxH6zDA

Transcript of the video, for those who are pressed for time: https://www.brainforest.org/post/leaky-gut-anatomy

I hope this helps someone understand their gut a little better on the path to health. Stay tuned for our next podcast on the relationship between leaky gut and aging. Share this resource with others who are studying gut anatomy on the path to health!

22 min