Current research, papers and pop-culture about the immune system. Kevin, Matt and Kate tackle it all!
Episode 29 - Camilla's Science is Cursed
I swear, we know how to count; this episode was originally recorded back in January, but Camilla's audio file was weirdly corrupted. And in this attempt, Chadene's computer exploded, but we soldiered on without her.
In this episode, we're discussing Camilla's PhD paper, in which bone-forming cells promote tumors in the lung by activating specialized neutrophils. Yeah, it doesn't make any sense to me either, but it's beautiful work.
LinksThe Paper: Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
Blog post (suitable for non-immunologists)
Kevin's beers: Whirlpool (from Night Shift) and Conehead (from Zero Gravity)
Camilla's beer: A Year with Dr. Nandu
Episode 32 - Not an accurate representation of grad school
Figure 2 B from https://doi.org/10.1073/pnas.1716937115
In this episode, Chadene, Kate and Kevin discuss Kate's recently published paper about how STING, once thought to be involved only in defense against DNA viruses, actually slows RNA virus replication as well. Also, Chadene throws herself under the bus, and Kevin manages to only talk for about 20% of the time.
LinksThe paper: STING-dependent translation inhibition restricts RNA virus replicationKate's... drink? - TW Pitchers Radler Kevin's beer: Mayflower Brewing Oatmeal Stout
Episode 31 - Two Bucket Disease
Graphical abstract from the paper. Guys, Matt and I don't charge that much to help with figure design...
In this episode, we're talking about Salmonella, and the peculiar way in which it tries to keep you eating to keep you alive. Who knew pathogens could be so kind?
Also, Chadene struggles to introduce the podcast, and Kate decides to Kevin 4 years later that we're misspelling the name of the podcast. Too late now!
LinksThe Paper: Pathogen-mediated inhibition of anorexia promotes host survival and transmission
Kate's Shandy (Sorry, I refuse to put a link to Rolling Rock)
Resorb - (eg Scandinavian magic)
Episode 30 - No Drop Shadows on Error Bars
Neutrophil grabbing Staph. From Wikipedia
No, your eyes aren't deceiving you, and yes, we know how to count... Episode 29 is still in limbo as Camilla valiantly attempts to re-record just her portion.
In this episode, Kevin and Camilla discuss Salmonella virulence, and how different strains alter the immunogenicity of pathogens. Oh, and Kate's here too... KATE'S BACK!! WOO!! Dr. Franz has a new job, but is just as snarky and ill-prepared as ever. Plus she refuses to drink on the job.
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EDIT: Sorry if this showed up in your feed late - there was a mistake in formatting :-(
LinksThe Paper: Strains of bacterial species induce a greatly varied acute adaptive immune response: the contribution of the accessory genome
Short Path Distillery
Organ Preservation Alliance (where Kate works now)
Episode 28 - Giant Bag of Autoimmunity
Blame Kevin for the delay on this one - it's hard to edit podcasts in Hong Kong.
Today (well, three weeks ago), Matt and Kevin talked about epitope spreading in Lupus, and a ton of crazy mouse models that allowed researchers to dissect the way a single auto-reactive B-cell clone can spread the disease party to its neighbors.
Also in this episode - Kevin complains about politicians' views on global warming (I can't link the map because of the government shutdown), and Matt totally doesn't have any conflicts of interest on this paper...
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Links- The Paper - Clonal evolution of autoreactive germinal centers (it's behind a paywall, and we definitely won't send you the PDF if you e-mail us at email@example.com... definitely not)
- Blah, Blah, Blah IPA from 21st Amendment
- What Matt was drinking. Not a mistake.
Episode 27 - Macaque Prison Gangs
In this episode, we're talking cure for the common cold... or at least, a vaccine for it. Also, Kevin and Matt read the wrong paper, Chadene corrects Kevin's pronunciation of her name (again!) and we give a big round of applause for Dr. Kate Franz (though she's still too busy for us).
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LinksThe Paper: A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques
Guardian article about the effort to develop a rhinovirus vaccine
Chadene's Blog - The SciMinded Idealist (and her post about episode 26)
Kevin's Beer - Left Hand Milk Stout
Customer ReviewsSee All
New to immunity and loving this podcast
Great resource. Nice hearing from grad students.
Complex topics explained well.
This is one of my favorite podcasts. They take complex topics from immunology and explain them in depth but extremely clearly. They move along at a good pace and the banter is enjoyable. More!
Makes me want to get a PhD in immunology... Or virology??
Very informative and fun. I've gone back and listened to all the episodes. Such an interesting subject.
I'd especially love to hear more above how pathogens hijack the immune system - the staph super antigen episode was fascinating. The pathogen/host-immune-system co-evolution is fascinating too.