How can heme pathway dysregulation cause issues in Autism?
Porphyria is a build up of toxins in the blood due to a heem pathway dysregulation. Porphyria are iron-containing heme which permits hemoglobin oxygen transportation in the blood. It is triggered by many things including fasting, genetics, nutrient imbalance, rapid detoxification, candida, Lyme, viruses, mold, heavy metals, glyphosate and other toxic insult. The technical name is Kryptopyrroles porphyrins, also referred to as Kryptopyrroluria (KPU).
This also triggers mast cell activation. Mast cells are types of white blood cells that help to regulate the immune system. Mast cells can determine how our bodies react to environmental triggers like sugar, pesticides, perfume, pollution, and other causes of inflammation.
Detoxifying for people with KPU must be done VERY slowly. Even the candida cleansing diet that removes sugars and processed carbohydrates can trigger a KPU response. The toxin release may also trigger an autoimmune response of PANS/PANDAS, since a Staphylococcus infection contributes to a build up of porphyrins. There is an accumulation of porphyrins and pyrrole pigments by Staphylococcus.
Some symptoms of kryptopyrroles porphyrins (KPU)
Rapid triggered extreme anxiety from the removal of sugars and carbs
heightened skin sensitivity, especially to sunlight,
cannot tolerate fasting or intermittent fasting,
bowel issues of either constipation or diarrhea,
cannot tolerate low carbohydrate or low sugar diet/candida diet (until heem pathways are balanced),
very low zinc levels. A common copper to zinc ratio imbalance.
Dr. Beth O’Hara’s biography
Beth O’Hara is a Functional Naturopath, specializing in complex chronic immune conditions related to Mast Cell Activation Syndrome and Histamine Intolerance. She is the founder and owner of Mast Cell 360, a Functional Naturopathy Practice designed to look at all factors surrounding health conditions – genetic, epigenetic biochemical, physiological, environmental, and emotional. Her subspecialties are Mold Toxicity and Genetic Analysis in the area of Mast Cell Activation and Histamine Intolerance.
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