The logic behind the science: Conversations with Broad researchers exploring what they do and why they do it, from Broad Institute of MIT and Harvard.
BioLogic: The transformative power of CRISPR in the lab, with John Doench and Ruth Hanna
John Doench, associate director of the Genetic Perturbation Platform (GPP) and institute scientist at the Broad Institute, and Ruth Hanna, research associate in GPP, discuss how the CRISPR system has revolutionized studies of gene function.
BioLogic: Ten years of perspective on GWAS, with Joel Hirschhorn
Joel Hirschhorn, institute member and co-director of the Metabolism Program at the Broad Institute and professor of pediatrics and genetics at Harvard Medical School and Boston Children’s Hospital, sits down with BioLogic to talk about how the research community has approached genome-wide association studies (GWAS) from concept to execution through the last decade.
BioLogic: Empowering psychiatric disease research through genetics, with Mark Daly
Broad Institute member Mark Daly, co-director of the Program in Medical and Population Genetics, investigator with the Stanley Center for Psychiatric Research, and chief of the Analytic and Translational Genetics Unit at Massachusetts General Hospital, describes how modern tools for analyzing the genome have empowered the study of psychiatric disorders.
BioLogic: The future of genome sequencing in healthcare, with Heidi Rehm and Robert Green
Genome sequencing may someday become a routine part of medical care, but questions still surround best practices for returning genetic information to patients in a way that will optimally impact their health. Geneticists Robert Green and Heidi Rehm explain their research into developing such protocols, the benefits and risks inherent in providing genetic information, and the uncertain future of legal protections against genetic discrimination.
BioLogic: Harnessing the immune system to fight cancer, with Nir Hacohen
Nir Hacohen, an institute member at Broad, director of the Center for Cancer Immunotherapy at Massachusetts General Hospital, and an associate professor at Harvard Medical School, takes us to the intersection of cancer, immunotherapy, and autoimmune disease to explore how researchers are steering the immune system to fight tumors.
BioLogic: The fight against antibiotic resistance, with Jim Collins
Jim Collins, an institute member at the Broad Institute, a core faculty member at the Wyss Institute for Biologically Inspired Engineering, and a professor at MIT, dives into the social and scientific causes of antibiotic resistance and explains some of what his lab is doing to combat the problem.