Discovery Engines

Nabil Laoudji, YesAnd Labs LLC
  • 5.0 (5)
  • SCIENCE
  • UPDATED SEMIMONTHLY
Discovery Engines

Featuring the people and platforms accelerating scientific discovery. Hosted by Nabil Laoudji. Our newsletter: www.discoveryengines.co

Episodes

  1. 1D AGO

    Unleashing Scientific Data - Nicholas Larus-Stone of Sphinx Bio, Bits in Bio

    Nicholas Larus-Stone is the Founder & CEO of Sphinx Bio, a startup helping life science labs unlock the full potential of their data to accelerate discovery. He’s also the Founder of Bits in Bio, a global community advancing science through software. See below for episode links, chapters, and our socials. Hosted by Nabil Laoudji. Support the podcast! Subscribe to our newsletter: www.discoveryengines.co. Thanks for watching 🙏🤙 Episode Links: Nicholas' LinkedIn Sphinx Bio Bits in Bio Folding Playground Google Co-Scientist Paper Recursion Defining TechBio Chapters: (00:00) - Preview & Introduction (04:34) - Why Biotech & Life Science (07:33) - About Small Molecule Discovery Companies Octant & Benevolent AI (11:47) - Why Is Software Second in Biotech? (14:35) - What Engineers Bring to Biotech (16:00) - Is Science Data-Starved or Data Rich? (19:23) - How Scientists Work With Data (28:10) - Observations That Led to Founding Sphinx Bio (31:48) - AI Co-Scientists (37:57) - How Platforms like Sphinx Are Powered (40:31) - Foundation Model Companies' Interest in Science (43:58) - How Sphinx Leverages AI Models (45:59) - Managing Hallucinations (47:52) - Scientists: Give AI Another Try (49:02) - The Business and Cycles of TechBio (53:32) - Google's Co-Scientist, Notebook LM, and Other Science Ventures (57:43) - Protein Folding Playground (00:58:58) - "Wrapper" Companies In Era of Foundation Model Commoditization (01:01:56) - Bits in Bio Community & Growth (01:04:25) - Try Sphinx's Platform; Work for Sphinx; Support Your Local ScientistConnect With Us: Our Newsletter Twitter Bluesky LinkedIn Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

    1h 6m

  2. APR 2

    Inside the DOE's Autonomous Lab for Materials Discovery - David Milsted, Lab Systems Engineer

    David Milsted is a postdoctoral researcher at the “A-Lab” for autonomous materials discovery, located at the Department of Energy’s Lawrence Berkeley National Laboratory. Please note: The views expressed in this video by David are his own and not those of his colleagues. See below for episode links, chapters, and our socials. Hosted by Nabil Laoudji. Support the podcast! Subscribe to our newsletter: www.discoveryengines.co. Thanks for watching 🙏🤙 Episode Links: David's LinkedIn Lawrence Berkeley National Lab A-Lab Ceder Group UC Berkeley Mississippi State University Wood Science Chapters: (00:00) - Preview & Introduction (04:37) - LBNL Fun Facts (05:40) - David’s Journey Into Lab Automation (Wood Science, Automation Engineering) (10:26) - Why Wood Science (14:54) - Journey From Brazil To LBNL (25:50) - Material Discovery Process Steps (29:37) - Predicting Materials Properties (35:07) - Synthesizing Materials With Automation (43:21) - Testing Novel Materials (44:58) - Orchestrating Automated Labs (A-Lab OS) (49:14) - Shifting From Independent to Team-Based Projects (53:28) - University-Government Lab Structure (57:41) - What Inspired A Lab’s Vision (01:02:40) - Growth in Autonomous Lab Investment (01:05:34) - Future of Characterization Via Microscopy (01:10:22) - A Lab Tour (Core Components) (01:15:44) - Vendor Support: Mitsubishi, Labman, MTI, etc (01:18:58) - Managing Input Inventory For Runs (01:20:12) - Furnace Deep Dive (01:24:06) - Parallel Processing (01:25:43) - Vendor Automation Out of the Box; Importance of Societal AwarenessConnect With Us: Our Newsletter Twitter Bluesky LinkedIn Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

    1h 30m

  3. MAR 19

    Unlocking Cancer Priming Therapies (& Lab Tour) - Transon Nguyen of Eigen Therapeutics

    Transon Nguyen is the CEO and Co-Founder of Eigen Therapeutics, a biotech startup leveraging AI and lab automation to develop priming therapies that make cancer easier to find and eliminate. Hosted by Nabil Laoudji. My guest co-host is Jimmy Sastra! This episode is sponsored by Monomer Bio. See below for episode links, chapters, and how to connect with us. Thanks for watching 🙏🤙 Episode Links: Eigen Therapeutics Transon Nguyen's LinkedIn Monomer Bio Jimmy Sastra's LinkedIn Radioligand Therapy Antibody–Drug Conjugates (ADCs) Laboratory Information Management System (LIMS) Chapters: (00:00) - Teaser (00:36) - Introducing My Guest Co-Host: Jimmy Sastra of Monomer Bio (11:24) - Introducing Transon Nguyen, CEO of Eigen Therapeutics (12:54) - Transon's Path Into Biomedical Engineering (15:45) - Science In Industry vs Academia: Importance of Culture (18:27) - Co-Founding Eigen Tx: A Confluence of Factors (24:27) - How to Find New Ideas (25:15) - Cost of ADCs and Radioligand Therapies (27:00) - Testing The Effectiveness of Priming Therapies (31:23) - How Patients Take Priming Therapies (33:19) - Importance of Empathy In Multidisciplinary Teams (37:54) - Lab Tour: Intro, Flexible Design (39:33) - Different "Homes" / Areas of The Lab (43:32) - Custom Built LIMS (48:54) - Robot Test Suite Demo (51:41) - A Look At Custom-Built LIMS (55:56) - Favorite Instruments (57:44) - Business of BioTech: Making The Numbers Work (59:09) - Don't Over-Automate (01:01:13) - Keeping The Lab Clean (01:03:01) - Moving Beyond Just Solving Problems (01:05:05) - Reframing Personal Identity and Seeing the Whole System (01:08:31) - Relevance of AI Foundation Models, Virtual Cells to Eigen's Mission (01:12:50) - Contact Transon to Learn More About Priming Therapies Connect With Us: Our Newsletter Twitter Bluesky LinkedIn Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

    1h 15m

  4. MAR 5

    Unlocking Lab Automation - Sudha Gollapudi & Madeline Wolf of The Automated Lab

    Sudha Gollapudi & Madeline Wolf (ex Genentech, Ginkgo Bioworks, Calico/Alphabet) are lab automation experts and co-founders of The Automated Lab: an open resource and contract engineering service for building automated labs. See below for episode links and chapters. Support the podcast! Subscribe to our newsletter. Thanks for watching 🙏🤙 Episode Links: The Automated Lab Open Source Resource Page Vivo Hamilton Liquid Handler Chatbot Automated Lab Patreon Sudha's LinkedIn Madeline's LinkedIn ELISA Biochemistry Assay Society for Laboratory Automation and Screening (SLAS) Chapters: (00:00) - Teaser (00:54) - Episode Introduction & Preview (05:38) - Sudha and Madeline’s Academic + Professional Experience (06:53) - Madeline’s Path Into Biotech Lab Automation (09:40) - Sudha’s Path Into Biotech Lab Automation (10:55) - Career Pathways Into Lab Automation (15:38) - What Encompasses Lab Automation? (17:29) - Lab Automation Example: Workcell for ELISA Immunological Assay (22:19) - Environmental Impact of Lab Automation (27:31) - SLAS Conference Hot Takes; Move to Smaller Footprint Products (36:28) - Modular-First Design In Lab Automation (41:51) - LIMs, ELNs, And Making Data More Accessible (46:10) - Solving the Human-Robot Interface With NLP, Flexible Data Infrastructure (52:23) - Automation For R&D vs Manufacturing (57:07) - Adapting The Culture of Science To Increased Automation (01:00:29) - Standardizing Scientific Language (01:08:02) - How To Partner With The Automated LabConnect With Us: Twitter Bluesky LinkedIn Instagram Newsletter Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

    1h 11m

  5. FEB 20

    Accelerating Cancer Research - Hani Goodarzi of Arc Institute, UCSF, Exai Bio

    Hani Goodarzi is Quantitative and Computational Biologist, Core Investigator at the Arc Institute, Associate Professor at UCSF, and co-founder of Exai Bio and Vevo Therapeutics. Episode links and chapters below. Hosted by Nabil Laoudji. Support the podcast! Subscribe to our newsletter. Thanks for watching 🙏🤙 Episode Links: Arc InstituteGoodarzi LabExai BioVevo TherapeuticsUCSF Cancer CenterHani's LinkedInGreg Brockman's PostNCI Cancer StatsChapters: (00:00) - Teaser (02:12) - Episode Introduction & Preview (07:35) - Hani’s Path Into Quantitative and Computational Biology (11:55) - The Emerging Promise of Foundation Models Such as Evo 2 (15:53) - Dry Side vs. Wet Side of Biology (22:23) - Pivoting Into AI for Life Science From Unrelated Domains, and the Importance of Culture in Cross-Functional Teams (27:28) - How to Develop Multidisciplinary Teams: Brutal Honesty (30:07) - How Arc Institute’s Org and Funding Structure Enables Innovative Science (36:24) - How Tech Founders Are Pushing Biotech Innovation (39:07) - Hani’s Collaboration with NVIDIA and Greg Brockman of OpenAI (43:57) - The Science Behind Exai’s Early Cancer Detection Platform (52:05) - DNA Methylation to Improve Cancer-Specific Signals From Blood (55:25) - UCSF’s Application of This Technology for Breast Cancer Detection (58:34) - How Startups Help Bridge the Science “Valley of Death” (01:04:24) - Supporting Hani’s Work Through Scientific Contributions, Evangelism, and Applying the Scientific Method Across DisciplinesConnect With Us: Twitter Bluesky LinkedIn Instagram Newsletter Feedback or questionsPlatforms: YouTube Apple Podcasts Spotify Podcasts

    1h 7m

  6. FEB 6

    Accelerating Scientist Founders - Hemai Parthasarathy of Google X, Thiel Foundation, Nature, MIT

    Hemai Parthasarathy is a neuroscientist (Johns Hopkins, MIT), Editor (Nature, PLOS), and expert at helping deep tech startups build and scale (Thiel Foundation, Google X, MIT The Engine). See below for episode links, chapters, our socials, and how to send us feedback. Want to dig deeper? Check out our newsletter. Thanks for hanging with us 🙏🤙 Episode Links: Hemai's LinkedinGoogle XBreakout VenturesThiel FoundationMIT The EngineNaturePLOS BiologyCenter for Open ScienceChapters: (00:00) - Preview & Introduction(04:36) - Hemai’s Experience: Google X, Breakout Labs, PLOS, Nature(05:40) - Starting As A Scientist(07:02) - How Science Actually Happens(10:02) - Why Science Communication(14:59) - PLOS Founding Story & Publishing Pledge(18:24) - Current State of Open Science & Scientific Publishing(23:37) - Founding Mission of Thiel Foundation’s Breakout Labs(27:36) - What Breakout Labs Got Right(29:54) - Protecting IP As A Deep Tech Startup(34:29) - Patient Capital and Corporate Innovation at Google X(41:02) - Bridging the Startup Valley of Death(44:11) - Factoring In Politics As A Deep Tech Founder(47:11) - New Entrants to Deep Tech(50:48) - E11’s Breakthroughs as a Focused Research Organization(54:55) - MIT’s The Engine for “Tough Tech”(56:43) - Annual Reviews & Helping Society Benefit from Scientific Knowledge(01:00:04) - Opportunities to Partner, Invest, and MentorConnect With Us: TwitterBlueskyLinkedInInstagramFeedback, questions, or discuss appearing on Discovery EnginesPlatforms: YouTubeApple PodcastsSpotify Podcasts

    1h 2m

  7. JAN 16

    Inside Biotech Lab Automation - Luis Villa of Bay Area Lab Automators

    Luis Villa co-founded Bay Area Lab Automators, and is a Senior Automation engineer at cell therapy manufacturing startup Cellares. See below for episode links, chapters, our socials, and how to send us feedback. Want to dig deeper? Check out our newsletter. Thanks for watching 🙏🤙 Episode Links: Bay Area Lab AutomatorsLuis' LinkedInLuis' BlueSkySF Hardware MeetupCellaresCarnegie Mellon MS in Automated SciencePyLabRobotDrug Development Process (Draft)Chapters: (00:00) - Preview & Introduction(04:28) - Choosing Lab Automation Engineering as a Career(08:19) - Day in the Life of an Automation Engineer(13:41) - Where Automation Engineers Sit Within an Org(15:28) - Culture of Lab Automation Community(20:16) - Pro Tips for Networking(22:46) - How to Advance the Biotech Industry(24:20) - Segmenting the Lab Automation Market(28:28) - Estimating the Size of the Lab Automation Market(30:49) - Building a Business in Lab Automation(34:17) - Closed vs. Open Systems(39:55) - Accelerating the Drug Discovery Process(44:55) - Challenges of Manufacturing Cell Therapies(51:26) - Rise of Autonomous/Closed-Loop Labs for Science(56:53) - Onshoring for National Security(1:03:23) - Evaluating Startup Pitches in Lab Automation(1:09:20) - Resources for Lab Automation(1:10:34) - Getting Involved with Lab AutomatorsConnect With Us: TwitterBlueskyLinkedInInstagramFeedback, questions, or discuss appearing on Discovery EnginesPlatforms: YouTubeApple PodcastsSpotify Podcasts

    1h 13m

  8. JAN 2

    AI-Powered Animal Research - Michael Kaca of Olden Labs

    Michael Kaca is Co-Founder and Chief Science Officer of Olden Labs, a startup bringing animal research into the modern age through a suite of custom hardware and ML algorithms. See below for episode links, chapters, our socials, and how to send us feedback. Want to dig in deeper?Check out our newsletter. Thanks for hanging with us 🙏 Episode Links: Olden LabsMichael's LinkedInOrgans On a Chip (OOC)FDA Drug Review ProcessWhy Animal ResearchChapters: (00:00) - Preview & Introduction(03:07) - Why Animal Studies?(06:24) - Artificial Organs and Modeling Complexity(08:19) - Ethics of Animal Testing(12:52) - Olden Labs’ Origin Story(16:40) - A Roboticist in Life Science(21:08) - Enabling Longevity(21:58) - DOME Smart Cage Overview(24:03) - Hands-On Hardware Walkthrough(28:50) - Challenges and Pivots in Hardware Design(32:06) - Software Walkthrough(38:46) - ML Model Visual Overlays(39:13) - DeepLabCut Comparison(42:24) - Metrics Tracking and Industry Standards(45:44) - High Fat Study Example(47:16) - Getting Customer Feedback(50:10) - Enabling Data-Driven Science(52:55) - Genetic Engineering Future(55:24) - Partnership Opportunities and HiringConnect With Us: ⁠Twitter⁠⁠Instagram⁠⁠Linkedin⁠⁠Feedback, questions, or discuss appearing on Discovery Engines⁠Platforms: ⁠⁠YouTube⁠⁠⁠Apple Podcasts⁠⁠Spotify Podcasts

    57 min

  9. 12/11/2024

    The Startup Building AI Scientists - Cristian Ponce & Théo Schäfer of Tetsuwan

    Cristian Ponce and Théo Schäfer are the co-founders of Tetsuwan, a startup building AI scientists to accelerate life science research. See below for episode links, chapters, our socials, and how to send us feedback. Want to dig deeper? Check out our newsletter. Thanks for hanging with us 🙏🤙 Episode Links: Tetsuwan ScientificCristian's LinkedInThéo's LinkedInAccelerate ConferenceSymbolic AI ExplainerChapters: (00:00) - Introduction(02:44) - Why AI Scientists(06:48) - Founding Story(13:50) - First Customer Delivery(22:06) - Building in EU or US(24:43) - State Of Life Science Robots(29:50) - Emerging Technological Enablers(41:44) - Rules-Based vs ML-Based AI(49:40) - Lab Automation Industry Today(57:38) - Addressing Safety(1:07:12) - How To Join TetsuwanConnect With Us: TwitterBlueskyLinkedInInstagramFeedback, questions, or discuss appearing on Discovery EnginesPlatforms: YouTubeApple PodcastsSpotify Podcasts

    1h 10m
  • 9 Episodes

Ratings & Reviews

5
out of 5
5 Ratings

About

Featuring the people and platforms accelerating scientific discovery. Hosted by Nabil Laoudji. Our newsletter: www.discoveryengines.co

Information

  • Creator
    Nabil Laoudji, YesAnd Labs LLC
  • Years Active
    2024 - 2025
  • Episodes
    9
  • Rating
    Clean
  • Copyright
    © Nabil Laoudji, YesAnd Labs LLC
  • Show Website
    Discovery Engines

To listen to explicit episodes, sign in.

Stay up to date with this show

Sign in or sign up to follow shows, save episodes, and get the latest updates.
Select a country or region

Africa, Middle East, and India

Asia Pacific

Europe

Latin America and the Caribbean

The United States and Canada