E055 - AI or Not - Marc Fiammante and Pamela Isom

Welcome to "AI or Not," the podcast where we explore the intersection of digital transformation and real-world wisdom, hosted by the accomplished Pamela Isom. With over 25 years of experience guiding leaders in corporate, public, and private sectors, Pamela, the CEO and Founder of IsAdvice & Consulting LLC, is a veteran in successfully navigating the complex realms of artificial intelligence, innovation, cyber issues, governance, data management, and ethical decision-making.

A newborn can look “mostly fine” and still be minutes away from a life-altering diagnosis. The hardest part is that the most effective treatment, therapeutic hypothermia, only works when clinicians can identify brain injury within about six hours after birth. That time pressure, plus limited access to EEG experts, leaves too many families without a clear answer when it matters most.

I sit down with Marc Fiammante, a retired IBM Fellow who became a PhD student at the Paris Brain Institute for one practical reason: legal access to the medical data needed to build better tools. We unpack what newborn EEG monitoring really looks like at the bedside, why black-box deep learning can fail the trust test in medicine, and how “symbolic AI” and signal processing can create decisions clinicians can audit. Marc Fiammante shares how listening to a neurophysiologist interpret EEGs led to a breakthrough approach that models brain dynamics, producing a distinctive “Batman mask” pattern in healthy newborns and enabling high-accuracy, traceable comparisons across patients.

We also get honest about what it takes to move from research to impact: strict data selection within the first six hours, avoiding confounders, navigating patents and publication rules across the US and Europe, and designing a lightweight, lower-cost path toward a portable device that more maternity wards can actually use. If you care about healthcare AI, explainable AI, AI governance, or real-world digital transformation, this conversation offers a grounded blueprint for building systems that augment clinicians rather than replace them.

Additional Links: 

https://www.sciencedirect.com/science/article/pii/S0169260725005826

https://patents.google.com/patent/WO2025186361A1/en

https://foundation.generali.at/en/  

https://www.thehumansafetynet.org