Ibuprofen, a member of the class of medications known as nonsteroidal anti-inflammatory drugs (NSAIDS), is one of the most widely used over the counter medications in the world. It is quite effective for treating pain, reducing fever, and lessening inflammation in the body. However, overuse of ibuprofen can lead to gastrointestinal problems, and may place stress upon the kidneys, and these renal complications can be magnified by the work demands that firefighters face (high aerobic and anaerobic output, dehydration, and heat exposure). Dr. Rob Amrine, a sports medicine physician, and Dr. Eric Stone, a gastroenterologist, join the podcast to talk about ibuprofen, potential side effects from its use, dosing, and potential alternatives.