11 episodes

At the Precision Evidence Podcast, we go beyond the abstract of medical papers to find medical research relevant and meaningful to patients and healthcare professionals and separate the news from the fake news in medicine. Finding, evaluating, and using clinical trials with relevant outcomes for patients and Evidence-Based Medicine is the focus of the podcast’s analysis of medical papers, discussions, and interviews with stakeholders. Hosted by Dr. Kim Kristiansen, M.D., and JG Staal.
Twitter: @PrecisionEBM email us at podcast@precision-evidence.com

Precision Evidence Kim Kristiansen & JG Staal

    • Science

At the Precision Evidence Podcast, we go beyond the abstract of medical papers to find medical research relevant and meaningful to patients and healthcare professionals and separate the news from the fake news in medicine. Finding, evaluating, and using clinical trials with relevant outcomes for patients and Evidence-Based Medicine is the focus of the podcast’s analysis of medical papers, discussions, and interviews with stakeholders. Hosted by Dr. Kim Kristiansen, M.D., and JG Staal.
Twitter: @PrecisionEBM email us at podcast@precision-evidence.com

    Clinically Relevance - Looking at Recent Research

    Clinically Relevance - Looking at Recent Research

    Clinical trials and research should always aim to provide information that is meaningful and relevant for patients.
    However, researchers are rarely addressing that topic when presenting results from trials.
    In this episode, we look at published papers from high-ranking journals to get a sense of the extent of that problem. 
    You may be surprised by our findings...

    • 8 min
    How to Get to Clinically Relevant Research

    How to Get to Clinically Relevant Research

    Discussing the statistical and clinical significance in clinical research and the big improvements for patients and healthcare if researchers stated ahead of starting the trial what they would consider clinically relevant.
    It would come from focusing on using the provided information to help patients and improve healthcare - and not just publishing a paper

    • 17 min
    Russia's Sputnik COVID19 Vaccine Trial - Efficacy and Limitations

    Russia's Sputnik COVID19 Vaccine Trial - Efficacy and Limitations

    The interim analysis of the Russian Sputnik COVID19 vaccine is published in The Lancet
    It demonstrates efficacy at 94.6% which is comparable to the Pfizer/BioNTech and Moderna vaccine interim analysis
    Safety is comparable as well
    There are, however,  when scrutinizing the study, some serious concerns with impact on the usefulness of the vaccine and reducing the precision of the evidence

    • 8 min
    Critical Appraisal of the Moderna COVID19 Vaccine Trial

    Critical Appraisal of the Moderna COVID19 Vaccine Trial

    We know from the news that the outcome in the Moderna vaccine trial is good with a reduction in risk at 94.1% by getting the vaccine
    But is the study as a whole clinically relevant and trustworthy?
    And how many people need to be given the vaccination to prevent one COVID19 infection? - Probably not what you would guess
    We will cover this and much more in this episode

    • 15 min
    The Precision of Clinical Research

    The Precision of Clinical Research

    You’ve probably often heard that “Clinical trials show..” or “ evidence support that..”
    Unfortunately, a research paper being published in a peer-reviewed medical journal is NOT a guarantee that it is clinically relevant  - even if it is a high ranking journal
    As it is often the case the devil is in the details, so it is necessary to both read and evaluate the paper’s details and to put it into the context where you need the information
    In this episode, we will talk about the details you nee

    • 19 min
    Covid-19 Vaccines Trials: Understanding the First Published Results

    Covid-19 Vaccines Trials: Understanding the First Published Results

    Analyzing the details of the Pfizer/BioNTech and AstraZeneca COVID19 Vaccine trials.
    What do the efficacy measures mean and how many persons must be vaccinated to prevent one COVID19 infection?
    We also look at what an mRNA vaccine is and what to expect from future studies

    • 14 min

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