There has been some controversy as to whether inflammation and neurodegeneration in MS may be two independent disease processes and, therefore, whether MS-related neurodegeneration may occur in the absence of inflammation, particularly in patients with progressive disease. A recent study analyzed the interdependence between inflammation, neurodegeneration, and disease progression in the various stages of MS, focusing especially on progressive disease. Join John DeLuca, PhD, as he discusses the results with Claudia Lucchinetti, MD, a member of the study's research team, and explores the implications of this work for the development of new therapies.
Part 5. Implications for New Therapies
Dr DeLuca and Dr Lucchinetti discuss neuroprotective/neural repair strategies, new targets for novel therapies, and attention to confounding disease.
Part 4. Unanswered Questions
Dr DeLuca and Dr Lucchinetti discuss the lack of efficacy of anti-inflammatory agents in progressive MS.
Part 3. Discussion
Dr DeLuca and Dr Lucchinetti discuss the pattern of T- and B-cells and distribution in tissues over time.
Part 2. Analyzing the Interdependence of Inflammation and Neurodegeneration
Dr DeLuca and Dr Lucchinetti discuss study objective, design and results.
Part 1. The Inflammation/Neurodegeneration Paradox
Dr DeLuca and Dr Lucchinetti discuss neurodegeneration and inflammation.